TRANSIENT RECEPTOR POTENTIAL VANILLOID 1 (TRPV1) ANKYRIN REPEAT DOMAIN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们感兴趣的是观察瞬时受体潜在香草素1(TRPV1)锚定蛋白重复结构域中C157S突变对ATP结合的影响。这对我们对TRPV1的许多其他研究工作--依赖于设计一种功能性的无半胱氨酸版本的TRPV1--以及对TRPV1通过C157的化学修饰对一些刺激性化合物(如大蒜)做出反应的过程的生物学影响都有影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are interested in seeing the effect of the C157S mutation within the Transient receptor potential vanilloid 1 (TRPV1) ankyrin repeat domain on ATP binding. This has implications for many of our other research efforts on TRPV1 - which rely on engineering a functional cysteine-less version of TRPV1 - as well as biological implications on the process by which TRPV1 responds to some pungent compounds like garlic through chemical modification of C157.