STRUCTURE OF A BACTERIAL NRAMP TRANSPORTER

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 二价金属，如铁和锰，是许多生化过程所必需的。细胞内二价金属动态平衡需要专门的跨膜转运蛋白。我们的目标是确定细菌NRAMP转运体的原子结构，作为了解NRAMP转运体如何使用质子梯度选择和运输二价阳离子的一步。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Divalent metals such as iron and manganese are essential to may biochemical processes. Cellular divalent metal homeostasis requires specialized transmembrane transporters. We aim to determine the atomic structure of a bacterial NRAMP transporter as a step in understanding how NRAMP transporters select and transport divalent cations using a proton gradient.