STRUCTURE OF A BACTERIAL NRAMP TRANSPORTER

细菌 NRAMP 转运蛋白的结构

• 批准号: 8361710
• 负责人: RACHELLE GAUDET
• 金额: $ 0.68万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361710
• 关键词: Biochemical Process; Divalent Cations; Funding; Grant; Homeostasis; Iron; Manganese; National Center for Research Resources; Principal Investigator; Protons; Research; Research Infrastructure; Resources; Source; Structure; United States National Institutes of Health; cost; divalent metal; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Divalent metals such as iron and manganese are essential to may biochemical processes. Cellular divalent metal homeostasis requires specialized transmembrane transporters. We aim to determine the atomic structure of a bacterial NRAMP transporter as a step in understanding how NRAMP transporters select and transport divalent cations using a proton gradient.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 二价金属如铁和锰是许多生物化学过程所必需的。 细胞二价金属稳态需要专门的跨膜转运蛋白。 我们的目标是确定细菌NRAMP转运蛋白的原子结构，作为理解NRAMP转运蛋白如何使用质子梯度选择和转运二价阳离子的一个步骤。