GLYCOBROWSER: A TOOL FOR CONTEXTUAL VISUALIZATION OF BIOL DATA & PATHWAYS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 糖科学家只能有效地利用嵌入在我们的本体中的形式化知识， 提供了灵活的界面，使他们能够以直观的方式可视化这些知识。 本体本身由节点和边组成，其含义可能对糖科学家来说并不明显。 是 有用的信息，必须以更熟悉的格式提供。 我们通过开发 GlycoBrowser，一个用于糖组学领域本体信息可视化的工具。 GlycoBrowser 利用GlycoVault的功能以及沿着其他几种技术，包括RDF (http：//www.w3.org/RDF/）、AJAX（http：//developers.sun.com/ajax/）、JavaScript、BRAHMS等来表示 以糖生物学家直观的方式提供结构信息，并将此信息与实验数据联系起来 （糖组学、蛋白质组学和转录组学分析）。 GycoBrowser提供聚糖的图形显示 生物合成途径和相关的实验数据。 聚糖使用标准品“即时”呈现， 功能性糖组学协会（CFG）认可的代表。 GlycoBrowser包括功能强大且 灵活的图形界面，包括从标准组件构建聚糖结构的方法， 在GlycO本体中表示。 例如，GlycoBrowser支持渲染图像的较大片段。 代谢途径和相关的实验数据（如各种聚糖的丰度和 各种糖基转移酶编码基因的转录物水平）显示在途径下方。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Glycoscientists can only make efficient use of the formalized knowledge embedded in our ontologies if they are provided with flexible interfaces that allow them to visualize this knowledge in a format that makes intuitive sense. The ontology itself consists of nodes and edges, whose meanings may not be obvious to the glycoscientist. To be useful, this information must be presented in a more familiar format. We addressed this need by developing GlycoBrowser, a tool for the visualization of ontological information in the glycomics domain. GlycoBrowser leverages the capabilities of GlycoVault, along with several other technologies, including RDF (http://www.w3.org/RDF/), AJAX (http://developers.sun.com/ajax/), Javascript, BRAHMS, etc. to represent structural information in a way that is intuitive for glycobiologists and to link this information to experimental data (glycomics, proteomics, and transcriptomics analyses). GycoBrowser provides a graphical display of glycan biosynthetic pathways and associated experimental data. Glycans are rendered "on the fly" using the standard representation endorsed by the Consortium for Functional Glycomics (CFG). GlycoBrowser include a powerful and flexible graphical interface, including methods for building glycan structures from canonical components that are represented in the GlycO ontology. For example, GlycoBrowser supports rendering of a larger segment of the metabolic pathway and relevant experimental data (such as the abundances of the various glycans and the transcript levels for various glycosyl transferase-encoding genes) are shown below the pathway.