Toxic Metals in the Northeast: From Biological To Envir*

东北地区的有毒金属：从生物到环境*

• 批准号: 7459218
• 负责人: Joshua W Hamilton
• 金额: $ 25万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7459218
• 关键词: ATP-Binding Cassette Transporters; Adverse effects; Arsenic; Awareness; Biological; Biological Markers; Cadmium; Chemicals; Cities; Collaborations; Communities; Community Outreach; Development; Education and Outreach; Emergency Situation; Endocrine; Environment; Environmental Health; Environmental Impact; Epidemiology; Food Webs; Fostering; Health; Human; Lead; Lead Poisoning; Mercury; Molecular Biology; Nature; New Hampshire; Physiological; Poison; Population; Prevention; Proteins; Proteomics; Research; Research Project Grants; Site; Solid; Stress; Toxicogenomics; Trace Elements; Training; Training Programs; Translations; Underrepresented Minority; United States Environmental Protection Agency; concept; design; disease registry; gene environment interaction; interest; outreach program; programs; response; stressor; superfund site; tool; toxic metal; translational study; wasting

DESCRIPTION (provide by applicant) Toxic metals are a major concern both at Superfund and other waste sites and in the environment in general. Eight of the top fifty substances on the Agency for Toxic Substances and Disease Registry (ATSDR) priority list are toxic metals, including the top three priority substances, arsenic, lead and mercury. Eight of the twenty-two substances on the U.S. Environmental Protection Agency (EPA) Office of Solid Waste and Emergency Response (OSWER) list of chemicals of highest concern at Superfund sites are toxic metals. Over 60% of the 1,200 current Superfund sites contain substantial contamination by toxic metals, and arsenic alone is present in over 70% of these sites. The overall objective of this renewal of the Dartmouth SBRP Project (Toxic Metals in the Northeast: From Biological to Environmental Implications) is to understand how arsenic and other toxic metals contribute to adverse effects on human health and the environment. The investigators have a particular emphasis on arsenic, which is the focus of research in all six of the research projects and which serves as a major integrator of the Program across disciplinary boundaries; they also have an emphasis on mercury, cadmium and lead. Other major integrating themes of the Program are the extensive application of toxicogenomics and biomarkers, and the analysis of multiple stressors as a major mechanism underlying the environmental health impact of toxic metals. This Program consists of four biomedical (Projects 2, 4, 5, 8) and two nonbiomedical Research Projects (Projects 6 and 7); three Scientific Support Cores (A, B, D); a Training Core and Community Outreach Core; and Administrative and Translation Cores. Research projects include Project 2 (Arsenic as an endocrine disruptor), Project 4 (Arsenic epidemiology, biomarkers and exposure assessment), Project 5 (Toxic metal interactions with cellular proteins), Project 6 (Arsenic hydrogeochemistry at the Coakley Superfund site), Project 7 (Trophic transfer of toxic metals in aquatic food webs) and Project 8 (Arsenic and ABC transporters). Scientific Support Cores include a Molecular Biology & Proteomics Core (MBP) (Core A), a Trace Elements Analysis Core (Core B) and a Biomarkers Core (Core D). The Community Outreach Project is focused on lead poisoning prevention awareness, targeting underserved minority populations in Manchester NH, and involves collaborations with agencies of the State of New Hampshire and the City of Manchester and several local non-profit community groups. The multi-disciplinary nature of this Program, combined with its unique Program-wide focus on arsenic and other toxic metals and its other integrating themes is designed to create and foster a truly interdisciplinary yet focused research, education, outreach and training program.

描述（由申请人提供） 有毒金属是超级基金和其他废物处理场以及整个环境中的一个主要问题。 有毒物质和疾病登记机构 (ATSDR) 优先清单上前 50 名的物质中有 8 种是有毒金属，其中前三名的优先物质是砷、铅和汞。 美国环境保护署 (EPA) 固体废物和应急响应办公室 (OSWER) 超级基金站点最受关注的化学品清单中的 22 种物质中有 8 种是有毒金属。 目前超级基金的 1,200 个场地中，超过 60% 受到有毒金属的严重污染，其中 70% 以上的场地中仅存在砷。达特茅斯 SBRP 项目（东北部有毒金属：从生物到环境影响）更新的总体目标是了解砷和其他有毒金属如何对人类健康和环境造成不利影响。 研究人员特别关注砷，这是所有六个研究项目的研究重点，也是该计划跨学科界限的主要整合者；他们还重点关注汞、镉和铅。该计划的其他主要整合主题是毒物基因组学和生物标志物的广泛应用，以及作为有毒金属环境健康影响的主要机制的多种应激源的分析。该计划由四个生物医学研究项目（项目 2、4、5、8）和两个非生物医学研究项目（项目 6 和 7）组成；三个科学支持核心（A、B、D）；培训核心和社区外展核心；以及管理和翻译核心。 研究项目包括项目 2（砷作为内分泌干扰物）、项目 4（砷流行病学、生物标志物和暴露评估）、项目 5（有毒金属与细胞蛋白质的相互作用）、项目 6（科克利超级基金站点的砷水文地球化学）、项目 7（水生食物网中有毒金属的营养转移）和项目 8（砷和 ABC） 运输商）。 科学支持核心包括分子生物学和蛋白质组学核心 (MBP)（核心 A）、微量元素分析核心（核心 B）和生物标志物核心（核心 D）。社区外展项目的重点是提高铅中毒预防意识，针对新罕布什尔州曼彻斯特服务不足的少数民族人口，并涉及与新罕布什尔州和曼彻斯特市的机构以及几个当地非营利社区团体的合作。该计划的多学科性质，结合其独特的对砷和其他有毒金属及其其他整合主题的全计划重点，旨在创建和培育真正的跨学科但重点突出的研究、教育、推广和培训计划。