CHEMISTRY CORE

化学核心

• 批准号: 7959632
• 负责人: Mark T Hamann
• 金额: $ 12.82万
• 依托单位: UNIVERSITY OF MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959632
• 关键词: Applications Grants; Biological Factors; Centers of Research Excellence; Chemistry; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Faculty; Funding; Grant; In Vitro; Individual; Institution; Lead; Mississippi; Modification; Neurosciences; Organism; Play; Psychotropic Drugs; Research; Research Personnel; Resources; Role; Source; Structure; United States National Institutes of Health; Universities; drug candidate; in vivo; marine organism; plant fungi

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major aims of the Chemistry Core of the Center of Research Excellence in Natural Products Neuroscience are to support the development and submission of R01/R21 grant applications by Junior Faculty from the University of Mississippi. The Core provides expertise for the isolation of the active principles from selected plants, fungi, and marine organisms with CNS activity, elucidate their structures and provide material for in vitro and in vivo pharmacological studies in order to develop new psychotropic drug candidates. The chemistry core also plays an advisory role for individual projects that require expertise in isolation and structure elucidation of secondary metabolites from selected organisms. The specific aims for the chemistry core as part of their support actvities include: (a) isolation of active secondary metabolites from organisms with CNS activities. (b) structure elucidation of isolated active principles (c) re-isolation or synthesis of 100mg-1g quantities of active components for in vitro and in vivo studies. (d) semi-synthetic modification of lead compounds to generate SAR data and to develop drug candidates.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 天然产物神经科学卓越研究中心化学核心的主要目标是支持密西西比大学初级教师开发和提交R 01/R21资助申请。 该核心提供从选定的植物，真菌和具有中枢神经系统活性的海洋生物中分离活性成分的专业知识，阐明其结构，并为体外和体内药理学研究提供材料，以开发新的精神药物候选物。化学核心还为需要从选定的生物体中分离和结构解析次级代谢物的专业知识的个别项目发挥咨询作用。作为其支助活动的一部分，化学核心的具体目标包括： (a)从具有CNS活性的生物体中分离活性次级代谢产物。 (b)分离的活性成分的结构解析 (c)再分离或合成100 mg-1 g量的活性组分用于体外和体内研究。 (d)先导化合物的半合成修饰以产生SAR数据并开发候选药物。