6: STOMATOGENESIS: SELF RENEWAL OF NEURAL STEM CELLS

6：造口发生：神经干细胞的自我更新

• 批准号: 7960398
• 负责人: JOSEPH M VERDI
• 金额: $ 12.75万
• 依托单位: MAINEHEALTH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960398
• 关键词: Cells; Centers of Research Excellence; Clinical; Communities; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; In Vitro; Institution; Laboratories; Legal patent; Process; Regenerative Medicine; Research; Research Personnel; Resources; Rest; Source; Stem cells; United States National Institutes of Health; design; nerve stem cell; self-renewal; stem cell biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. PROJECT 6: STOMATOGENESIS: SELF RENEWAL OF NEURAL STEM CELLS Self-renewal of stem cells is a highly studied process. In the stem cell community, most clinical hopes rest on the ability to garner sufficient numbers of multipotential stem cells for cell replacement strategies. Advancements have been incremental at best, and nothing that points to any biomedical application. This laboratory has patented a unique paradigm to stimulate stem cell self-renewal in vitro without changing the responsiveness to endogenous differentiation factors. This project is designed to determine the differences in transcriptomes of neural stem cells treated with Jagged that promotes Self-renewal, and Delta that we previously showed instructed gliogenic differentiation.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 项目6：造口：神经干细胞的自我更新 干细胞的自我更新是一个高度研究的过程。 在干细胞领域，大多数临床希望在于获得足够数量的多潜能干细胞用于细胞替代策略的能力。 进步充其量是渐进的，没有任何东西指向任何生物医学应用。 该实验室已获得专利的独特范例，刺激干细胞在体外自我更新，而不改变对内源性分化因子的反应。 该项目旨在确定用促进自我更新的Jagged处理的神经干细胞的转录组的差异，以及我们先前显示的指示胶质细胞分化的Delta。