6: STOMATOGENESIS: SELF RENEWAL OF NEURAL STEM CELLS

6：造口发生：神经干细胞的自我更新

• 批准号: 8167692
• 负责人: JOSEPH M VERDI
• 金额: $ 13.09万
• 依托单位: MAINEHEALTH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167692
• 关键词: Cells; Clinical; Communities; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; In Vitro; Institution; Laboratories; Legal patent; Process; Research; Research Personnel; Resources; Rest; Source; Stem cells; United States National Institutes of Health; design; nerve stem cell; self-renewal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. PROJECT 6: STOMATOGENESIS: SELF RENEWAL OF NEURAL STEM CELLS Self-renewal of stem cells is a highly studied process. In the stem cell community, most clinical hopes rest on the ability to garner sufficient numbers of multipotential stem cells for cell replacement strategies. Advancements have been incremental at best, and nothing that points to any biomedical application. This laboratory has patented a unique paradigm to stimulate stem cell self-renewal in vitro without changing the responsiveness to endogenous differentiation factors. This project is designed to determine the differences in transcriptomes of neural stem cells treated with Jagged that promotes self-renewal, and Delta that we previously showed instructed gliogenic differentiation.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 项目 6：造口：神经干细胞的自我更新 干细胞的自我更新是一个经过深入研究的过程。 在干细胞界，大多数临床希望依赖于获得足够数量的多能干细胞用于细胞替代策略的能力。 进步充其量只是渐进式的，并没有指向任何生物医学应用。 该实验室已获得独特范例的专利，可在不改变对内源分化因子的反应性的情况下刺激体外干细胞自我更新。 该项目旨在确定经 Jagged 处理的神经干细胞转录组的差异，以促进自我更新，而我们之前展示的 Delta 则指示神经胶质细胞分化。