CENTER FOR THE ANALYSIS OF CELLULAR MECHANISMS AND SYSTEMS BIOLOGY
细胞机制和系统生物学分析中心
基本信息
- 批准号:7960476
- 负责人:
- 金额:$ 57.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-03-01 至 2010-02-28
- 项目状态:已结题
- 来源:
- 关键词:Advisory CommitteesAreaBiologicalCellsChemicalsCommittee MembersComputer Retrieval of Information on Scientific Projects DatabaseComputer softwareDNA Microarray ChipDataDetectionDevelopmentDigestionDiseaseFacultyFundingGenomicsGoalsGrantInstitutionMass Spectrum AnalysisMentorsMetabolicMethodsMicrofluidicsModelingMolecularMontanaOrganic SynthesisPost-Translational Protein ProcessingProteinsProteomicsReagentRecoveryResearchResearch InfrastructureResearch PersonnelResourcesSeedsSourceSystemSystems BiologyTrainingUnited States National Institutes of HealthWorkenzyme activityimprovedmass spectrometermembermetabolomicsmultidisciplinarynanopointed proteintool
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The goal of this project is to develop a multidisciplinary Center for the Analysis of Cellular Mechanisms and Systems Biology, to provide new infrastructure to advance understanding of cellular mechanisms, to better understand how to overcome disease, and to build a critical mass of faculty in this area. The Center is unique in Montana and the five surrounding states, and will include a combination of capabilities for analysis of cellular mechanisms. This project will create a powerful Mass Spectrometry and Proteomics Core infrastructure, oriented toward training researchers. Most cellular mechanisms appear to be controlled by protein post-translational modifications and the MS and Proteomics Core will add new mass spectrometers for improved characterization of modifications of proteins, high sensitivity microfluidic nano LC/MS/MS, a Hyperspectral imager for enhanced multicolor proteomic multiplexing to pin-point proteins that change with biological stimulation, and a protein electro-elution and microfluidic digestion system for high efficiency recovery of pin-pointed proteins.
Sensitive differential protein detection capabilities developed at MSU and will be included in the Core. New software will integrate data from an existing DNA microarray Facility. A Proteomics Reagent Synthesis Core will prepare new fluorescent reagents for differential analysis of changes in enzyme activity and post-translational modifications that result from biological stimulation.
Critical mass will be built by supporting the development of three junior faculty and one senior faculty member, who is charting a new course in his research. Outstanding local and national mentors and External Advisory Committee members will guide the development of these faculty and the Center. Over the period of the project we plan to hire four new faculty in areas needed to build critical mass: a Chemical Biologist/Organic Synthesis expert, a Biological Mass Spectroscopist using advanced MS tools, a Systems Biologist working on metabolic modeling and metabolomics, and a Cell Biologist using global molecular tools. Outstanding MSU Institutional Support, the significance and timeliness of the post-genomic analysis of cellular mechanisms, and the orientation toward training in advanced methods will seed new projects-and will result in significant scientific contributions and a sustainable Center.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
该项目的目标是建立一个多学科的细胞机制和系统生物学分析中心,提供新的基础设施,以促进对细胞机制的理解,更好地了解如何克服疾病,并在这一领域建立一个临界质量的教师。该中心在蒙大拿州和周边五个州是独一无二的,将包括细胞机制分析的能力组合。该项目将创建一个强大的质谱和蛋白质组学核心基础设施,面向培训研究人员。大多数细胞机制似乎是由蛋白质翻译后修饰控制的,MS和蛋白质组学核心将增加新的质谱仪,用于改进蛋白质修饰的表征,高灵敏度微流控纳米LC/MS/MS,用于增强蛋白质组学多路复用的高光谱成像仪,以精确定位随生物刺激而变化的蛋白质,以及蛋白质电洗脱和微流体消化系统,用于高效回收定点蛋白质。
在MSU开发的敏感差异蛋白检测能力将被纳入核心。新软件将整合现有DNA微阵列设备的数据。蛋白质组学试剂合成核心将制备新的荧光试剂,用于生物刺激引起的酶活性变化和翻译后修饰的差异分析。
临界质量将通过支持三名初级教师和一名高级教师的发展来建立,他们正在制定一项新的研究课程。优秀的地方和国家导师和外部咨询委员会成员将指导这些教师和中心的发展。在项目期间,我们计划在建立临界质量所需的领域聘请四名新教师:一名化学生物学家/有机合成专家、一名使用先进MS工具的生物质谱仪、一名从事代谢建模和代谢组学工作的系统生物学家,以及一名使用全球分子工具的细胞生物学家。杰出的MSU机构支持,细胞机制的后基因组分析的重要性和及时性,以及先进方法培训的方向将为新项目提供种子,并将产生重大的科学贡献和可持续发展的中心。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('EDWARD A DRATZ', 18)}}的其他基金
CENTER FOR THE ANALYSIS OF CELLULAR MECHANISMS AND SYSTEMS BIOLOGY
细胞机制和系统生物学分析中心
- 批准号:
8359565 - 财政年份:2011
- 资助金额:
$ 57.31万 - 项目类别:
CENTER FOR THE ANALYSIS OF CELLULAR MECHANISMS AND SYSTEMS BIOLOGY
细胞机制和系统生物学分析中心
- 批准号:
8167555 - 财政年份:2010
- 资助金额:
$ 57.31万 - 项目类别:
Center for the Analysis of Cellular Mechanisms and Systems Biology
细胞机制和系统生物学分析中心
- 批准号:
7901876 - 财政年份:2009
- 资助金额:
$ 57.31万 - 项目类别:
Center for the Analysis of Cellular Mechanisms and Systems Biology
细胞机制和系统生物学分析中心
- 批准号:
8605372 - 财政年份:2008
- 资助金额:
$ 57.31万 - 项目类别:
Multiplex Fluorescent Zdyes for Differential Glycomic Detection
用于差异糖组检测的多重荧光 Zdyes
- 批准号:
7395128 - 财政年份:2008
- 资助金额:
$ 57.31万 - 项目类别:
Multiplex Fluorescent Zdyes for Differential Glycomic Detection
用于差异糖组检测的多重荧光 Zdyes
- 批准号:
7944483 - 财政年份:2008
- 资助金额:
$ 57.31万 - 项目类别:
CENTER FOR THE ANALYSIS OF CELLULAR MECHANISMS AND SYSTEMS BIOLOGY
细胞机制和系统生物学分析中心
- 批准号:
7721041 - 财政年份:2008
- 资助金额:
$ 57.31万 - 项目类别:
Multiplex Fluorescent Zdyes for Differential Glycomic Detection
用于差异糖组检测的多重荧光 Zdyes
- 批准号:
7577536 - 财政年份:2008
- 资助金额:
$ 57.31万 - 项目类别:
Center for the Analysis of Cellular Mechanisms and Systems Biology
细胞机制和系统生物学分析中心
- 批准号:
7692996 - 财政年份:2008
- 资助金额:
$ 57.31万 - 项目类别:
Center for the Analysis of Cellular Mechanisms and Systems Biology
细胞机制和系统生物学分析中心
- 批准号:
7516132 - 财政年份:2008
- 资助金额:
$ 57.31万 - 项目类别:
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