COBRE in Stem Cell Biology and Regenerative Medicine

COBRE 在干细胞生物学和再生医学中的应用

• 批准号: 7682065
• 负责人: DON Michael WOJCHOWSKI
• 金额: $ 195.12万
• 依托单位: MAINEHEALTH
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7682065
• 关键词: COBRE; Stem; Cell; Biology; Regenerative

DESCRIPTION (provided by applicant): An understanding of unique properties of stem and progenitor cells is advancing rapidly. Initial successes in manipulating such cells for therapeutic advantages have intensified investigations (and enabled national centers that focus on embryonic stem cell plasticity, adult stem cell sources & potentials, and therapies for defined disorders). This revolution has opened new doors, but has also raised important new questions concerning key niche-specific regulators of progenitor cell growth, survival, and development. Our COBRE Program has been developed to address such questions. In Phase-l, we have: assembled a thematically focused team of talented investigators; engaged expert IAC, EAC and mentoring components; acquired several R01 and K01 awards; made major infrastructural advances (e.g., new cores in cell separation, histopathology, bioinformatics and a new research building addition); and have extended intra-inter Institute interactions. Impacting scientific discoveries also have been made. In Phase-ll, aims are to: #1 Support six exciting new research projects to advance mechanistic understanding of blood, vascular, neural, and skeletal muscle progenitor cell development in important disease and injury contexts; #2 Guide additional investigators to R01 funded status, recruit an additional senior scientist and at least two additional outstanding new junior investigators to bolster our Program; #3 Further develop key core facilities; #4 Continue to fortify infrastructure (new research wing, State biomedical bonds); and #5 Support new interactive seed projects towards synergistic co-investigator programs, and grant support. We will continue to investigate important niche-specific progenitor cell problems, and will focus on: BMP orthologue regulation of kidney response to injury and regeneration; R-spondin2 as a novel candidate regulator of skeletal muscle regeneration; Mechanisms of mural cell assisted de novo blood vessel formation from hES cells; DNA break repair in stem cells and affected microenvironments during lymphomagenesis; Slug as a key regulator of hematopoietic stem cell survival; and Jagged 1 maintenance of neural stem cell expansion and pluripotency. These projects share common scientific (and clinically relevant) themes; will foster state and national interactions; will advance the field (and funding) in significant ways; and will attract additional high caliber investigators to our Program. Overall efforts will forge a nationally competitive Center in this exciting discipline.

描述（由申请人提供）：对干细胞和祖细胞独特性质的理解正在迅速发展。操纵这些细胞以获得治疗优势的初步成功加强了研究（并使国家中心专注于胚胎干细胞可塑性，成人干细胞来源和潜力以及定义疾病的治疗）。这场革命打开了新的大门，但也提出了关于祖细胞生长，存活和发育的关键利基特异性调节剂的重要新问题。我们的COBRE计划就是为了解决这些问题而开发的。在第一阶段，我们有：组建了一个以主题为重点的优秀调查人员团队;聘请了专家IAC、EAC和指导组件;获得了多个R 01和K 01奖项;在基础设施方面取得了重大进展（例如，细胞分离、组织病理学、生物信息学的新核心和一座新的研究大楼）;并扩大了研究所内部的互动。也有一些影响深远的科学发现。在第二阶段，目标是：#1支持六个令人兴奋的新研究项目，以促进在重要疾病和损伤背景下对血液，血管，神经和骨骼肌祖细胞发育的机制理解; #2指导更多的研究人员获得R 01资助状态，招募额外的高级科学家和至少两名额外的优秀新初级研究人员来支持我们的计划;#3进一步发展关键的核心设施; #4继续加强基础设施（新的研究翼，国家生物医学债券）;#5支持新的互动种子项目，以实现协同合作研究者计划，并给予支持。我们将继续研究重要的生态位特异性祖细胞问题，并将集中在：BMP同源物调节肾脏对损伤和再生的反应; R-spondin 2作为骨骼肌再生的新候选调节因子; hES细胞辅助新生血管形成的机制;干细胞中的DNA断裂修复和淋巴瘤发生过程中受影响的微环境; Slug作为造血干细胞存活的关键调节因子;以及Jagged 1维持神经干细胞扩增和多能性。这些项目共享共同的科学（和临床相关）主题;将促进州和国家的互动;将以显著的方式推进该领域（和资金）;并将吸引更多的高素质研究人员加入我们的计划。总体努力将在这一令人兴奋的学科中建立一个具有全国竞争力的中心。