INVESTIGATIONS OF A NEW TYPE ENDOCRINE DISRUPTOR, TCC

新型内分泌干扰物 TCC 的研究

• 批准号: 8172562
• 负责人: Bill Lee Lasley
• 金额: $ 3.8万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172562
• 关键词: Address; Adverse effects; Animal Model; Benign Prostatic Hypertrophy; Computer Retrieval of Information on Scientific Projects Database; Data; Endocrine; Exposure to; Funding; Grant; Human; Institution; Investigation; Malignant Neoplasms; Organ; Research; Research Personnel; Resources; Rodent; Self Care; Source; United States National Institutes of Health; human disease; nonhuman primate; reproductive; reproductive development; reproductive function; triclocarban

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of the project is to investigate the effects of triclocarban (TCC), a new type endocrine disruptor on reproductive function, reproductive development and the potential effects on inducing cancer in reproductive organs. The results of this project will address concerns relating to the potential effects of adverse effects in humans as a result of exposure to TCC-containing personal care products. The studies using the non-human primate animal model are necessary to provide data that is more relevant to human diseases such as benign prostatic hyperplasia (BPH), compared to traditional data collected with rodent animal models.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目的目的是研究一种新型内分泌破坏者Triclocarban（TCC）对生殖功能，生殖发育以及对生殖器官诱导癌症的潜在影响的影响。 该项目的结果将解决与接触含TCC的个人护理产品的导致人类不良影响的潜在影响有关的问题。 与使用啮齿动物模型收集的传统数据相比，使用非人类灵长类动物模型的研究对于提供与人类疾病（例如良性前列腺增生（BPH））更相关的数据是必要的。