INVESTIGATIONS OF A NEW TYPE ENDOCRINE DISRUPTOR, TCC

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 本项目的目的是研究新型内分泌干扰物三氯卡班(TCC)对生殖功能、生殖发育的影响以及在生殖器官中诱发癌症的潜在作用。该项目的成果将解决与接触含有三氯甲烷的个人护理产品对人类的潜在不良影响有关的关切。与用啮齿动物模型收集的传统数据相比，使用非人类灵长类动物模型的研究是必要的，以提供与良性前列腺增生症(BPH)等人类疾病更相关的数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The objective of the project is to investigate the effects of triclocarban (TCC), a new type endocrine disruptor on reproductive function, reproductive development and the potential effects on inducing cancer in reproductive organs. The results of this project will address concerns relating to the potential effects of adverse effects in humans as a result of exposure to TCC-containing personal care products. The studies using the non-human primate animal model are necessary to provide data that is more relevant to human diseases such as benign prostatic hyperplasia (BPH), compared to traditional data collected with rodent animal models.