ENDOCRINE CORE SERVICES

内分泌核心服务

• 批准号: 7715570
• 负责人: Bill Lee Lasley
• 金额: $ 2.71万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715570
• 关键词: Androgens; Bioavailable; Biological Assay; Carrier Proteins; Cells; Chorionic Gonadotropin; Computer Retrieval of Information on Scientific Projects Database; Detection; Electromagnetics; Endocrine; Estrogens; Faculty; Feces; Funding; Grant; High Pressure Liquid Chromatography; Hormones; Housing; Individual; Institution; Luteinizing Hormone; Macaca; Measurement; Metabolic; Monkeys; Plasma; Research; Research Personnel; Resources; Saliva; Scientist; Services; Source; Therapeutic Human Experimentation; Thyroid Gland; United States National Institutes of Health; Urine; assay development; base; monoamine; steroid hormone

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The Endocrine Core has provided assays for twenty-two scientists, and recharged approximately $166,000. Our assays include routine analysis of steroid hormones in plasma, feces, urine and saliva and unique analyses that are not available elsewhere. Similarly, its assay development is directed towards providing assays that are used by our faculty and collaborators but are not readily available to them. During the past year the Endocrine Core has extended its service to include metabolic hormones and carrier proteins. It is our intent to provide in-house service for all assays requested through Therapeutics, Research Services and by individual investigators. Some of the new assays are being formatted on the ACS-180 automated chemiluminescence platform. A macaque thyroid panel as well as monkey chorionic gonadotropin (mCG) assays are now available. New cell based bioassays now provide direct measurements of circulating bioavailable estrogens, androgens and luteinizing hormone. HPLC with electromagnetic detection is being developed for assay of monoamines.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：内分泌核心中心已经为22名科学家提供了化验，并充值了大约166,000美元。我们的分析包括对血浆、粪便、尿液和唾液中类固醇激素的常规分析，以及其他地方没有的独特分析。同样，它的化验开发旨在提供供我们的教职员工和合作者使用但他们不容易获得的化验。在过去的一年里，内分泌核心扩大了它的服务范围，包括代谢激素和载体蛋白。我们的意图是为所有通过治疗、研究服务和个人调查人员要求的分析提供内部服务。一些新的分析方法正在ACS-180自动化学发光平台上格式化。猕猴甲状腺仪表板和猕猴绒毛膜促性腺激素(MCG)检测现已推出。新的基于细胞的生物测定现在提供了循环中生物可用雌激素、雄激素和黄体生成素的直接测量。电磁检测的高效液相色谱技术正在被开发用于单胺类化合物的检测。