ACUTE SIV INFECTION: BONE MARROW MONOCYTE OUTPUT AND VIRUS IMPORT INTO THE CNS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究的总体目标是描述单核细胞作为获得性免疫缺陷病毒综合征（AIDS）动物模型中病毒进入大脑的“特洛伊木马”的作用。具体的目的是研究急性感染期间可能改变的骨髓功能和单核细胞输出，以及单核细胞一旦出现在外周血池中，如何向前迁移到中枢神经系统。定义外周血池中新释放的单核细胞的特征及其早期脑浸润的能力可能导致新的药物靶向和治疗选择，通过靶向特定的单核细胞亚群或其迁移信号来抑制急性和慢性神经炎症。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this proposed study is to characterize the role of monocytes as 'Trojan Horse' for viral brain entry in an animal model for acquired immunodeficiency virus syndrome (AIDS). The specific objective is to examine possible altered bone marrow functions and monocyte output during acute infection and how monocytes, once emerged into the peripheral blood pool, migrate onward into the Central Nervous System. Defining the characteristics of newly released monocytes in the peripheral blood pool and their capacity for early brain infiltration could lead to novel drug targeting and treatment options that inhibit acute and chronic neuroinflammation by targeting specific monocyte subsets or their migratory signals.