ACUTE SIV INFECTION: BONE MARROW MONOCYTE OUTPUT AND VIRUS IMPORT INTO THE CNS

急性 SIV 感染：骨髓单核细胞输出和病毒输入中枢神经系统

• 批准号: 8172610
• 负责人: Michael B. McChesney
• 金额: $ 7.6万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172610
• 关键词: Acute; Animal Model; Bone Marrow; Brain; Characteristics; Chronic; Computer Retrieval of Information on Scientific Projects Database; Drug Delivery Systems; Equus caballus; Funding; Goals; Grant; HIV; Infection; Infiltration; Institution; Lead; Neuraxis; Output; Research; Research Personnel; Resources; Role; Signal Transduction; Source; United States National Institutes of Health; Viral; Virus; monocyte; neuroinflammation; novel; peripheral blood

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this proposed study is to characterize the role of monocytes as 'Trojan Horse' for viral brain entry in an animal model for acquired immunodeficiency virus syndrome (AIDS). The specific objective is to examine possible altered bone marrow functions and monocyte output during acute infection and how monocytes, once emerged into the peripheral blood pool, migrate onward into the Central Nervous System. Defining the characteristics of newly released monocytes in the peripheral blood pool and their capacity for early brain infiltration could lead to novel drug targeting and treatment options that inhibit acute and chronic neuroinflammation by targeting specific monocyte subsets or their migratory signals.

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