MAINTENANCE OF IMMUNOLOGIC MEMORY TO MEASLES VACCINE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：建立恒河猴对麻疹疫苗长期免疫记忆的动物模型。麻疹病毒对恒河猴具有致病性，受感染猴子的免疫反应与人类相似。用麻疹减毒活疫苗接种猴子，可保护它们免受致病性麻疹病毒攻击后的全身感染和疾病。这一提议有两个目标和假设。1.记忆B和T细胞在血液和身体组织中的循环与幼稚细胞不同，淋巴细胞循环和组织中保留的模式与最初的免疫途径有关。2.在长期记忆中持续存在的记忆B细胞和T细胞的水平是由初次免疫应答期间产生的病毒抗原的量决定的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The goal of this proposal is to establish an animal model of long-term immunologic memory to measles vaccine in the rhesus monkey. Measles virus is pathogenic in rhesus monkeys and the immune responses of infected monkeys are similar to those in humans. Vaccination of monkeys with live-attenuated measles vaccine protects them from systemic infection and disease after challenge with pathogenic measles virus. There are two aims and hypotheses for this proposal. 1. Memory B and T cells circulate in the blood and through body tissues differently than do naive cells, and patterns of lymphocyte circulation and retention in tissues are related to the initial route of immunization. 2. The levels of memory B and T cells that persist during long-term memory are determined by the amount of viral antigen produced during the primary immune response.