MENINGOCOCCAL VACCINES IN INFANT RHESUS MACAQUES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 儿童脑膜炎奈瑟菌感染仍然是严重神经系统后遗症的重要原因，常规疫苗接种无效。中和抗体和杀菌抗体都是保护性的，但婴儿的免疫系统对荚膜多糖免疫原没有足够的反应。该项目测试了几种用不同佐剂配制的脑膜炎双球菌免疫原，旨在提高婴儿宿主的杀菌抗体反应。经筛选无脑膜炎抗体的恒河猴婴儿饲养在野外自然环境中，将在3个月大时接种脑膜炎双球菌疫苗，然后在4个月大时进行加强注射。本次免疫原性研究将测定杀菌抗体效价。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Pediatric infection with Neisseria meningititidis remains an important cause of serious illness with neurologic sequellae for which conventional vaccination has been ineffective. Both neutralizing and bactericidal antibodies are protective but the infant immune system does not respond adequately to capsular polysaccharide immunogens. This project tests several meningococcal immunogens formulated with different adjuvants designed to improve the bactericidal antibody response in the infant host. Infant rhesus monkeys, screened for absence of meningoccal antibody and housed in a natural environment, the outdoor field cage, will be immunized with meningococcal vaccines at 3 months of age, followed by a booster injection at 4 months. The titers of bactericidal antibody will be measured in this immunogenicity study.