MENINGOCOCCAL VACCINES IN INFANT RHESUS MACAQUES

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 儿童脑膜炎奈瑟菌感染仍然是导致严重疾病并产生神经系统后遗症的重要原因，而传统疫苗接种对此无效。中和抗体和杀菌抗体均具有保护作用，但婴儿免疫系统对荚膜多糖免疫原的反应不充分。该项目测试了几种用不同佐剂配制的脑膜炎球菌免疫原，旨在改善婴儿宿主的杀菌抗体反应。 幼年恒河猴经过筛查是否存在脑膜炎球菌抗体，并饲养在自然环境（室外野外笼子）中，将在 3 个月大时接种脑膜炎球菌疫苗，然后在 4 个月大时进行加强注射。 在此免疫原性研究中将测量杀菌抗体的滴度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Pediatric infection with Neisseria meningititidis remains an important cause of serious illness with neurologic sequellae for which conventional vaccination has been ineffective. Both neutralizing and bactericidal antibodies are protective but the infant immune system does not respond adequately to capsular polysaccharide immunogens. This project tests several meningococcal immunogens formulated with different adjuvants designed to improve the bactericidal antibody response in the infant host. Infant rhesus monkeys, screened for absence of meningoccal antibody and housed in a natural environment, the outdoor field cage, will be immunized with meningococcal vaccines at 3 months of age, followed by a booster injection at 4 months. The titers of bactericidal antibody will be measured in this immunogenicity study.