MENINGOCOCCAL VACCINES IN INFANT RHESUS MACAQUES

幼年恒河猴的脑膜炎球菌疫苗

• 批准号: 8357327
• 负责人: Michael B. McChesney
• 金额: $ 5.04万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357327
• 关键词: Adjuvant; Age-Months; Antibodies; Antibody Formation; Antigens; California; Childhood; Environment; Funding; Grant; Housing; Immune system; Infant; Infection; Injection of therapeutic agent; Macaca mulatta; Measures; Meningococcal vaccine; National Center for Research Resources; Neisseria; Neurologic; Polysaccharides; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; Testing; United States National Institutes of Health; Vaccination; bactericide; cost; design; immunogenicity; improved

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Pediatric infection with Neisseria meningititidis remains an important cause of serious illness with neurologic sequellae for which conventional vaccination has been ineffective. Both neutralizing and bactericidal antibodies are protective but the infant immune system does not respond adequately to capsular polysaccharide immunogens. This project tests several meningococcal immunogens formulated with different adjuvants designed to improve the bactericidal antibody response in the infant host. Infant rhesus monkeys, screened for absence of meningoccal antibody and housed in a natural environment, the outdoor field cage, will be immunized with meningococcal vaccines at 3 months of age, followed by a booster injection at 4 months. The titers of bactericidal antibody will be measured in this immunogenicity study.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 小儿脑膜炎奈瑟氏菌感染仍然是导致严重神经系统后遗症疾病的重要原因，而常规疫苗接种对其无效。中和抗体和杀菌抗体都是保护性的，但婴儿免疫系统对荚膜多糖免疫原没有充分的反应。该项目测试了几种脑膜炎球菌免疫原，这些免疫原用不同的佐剂配制，旨在提高婴儿宿主的杀菌抗体反应。 筛选无脑膜炎球菌抗体并圈养在自然环境（室外野外笼）中的幼恒河猴，将在3月龄时接种脑膜炎球菌疫苗，然后在4月龄时加强注射。 本免疫原性研究将测定杀菌抗体滴度。