MEASLES VACCINE DEVELOPMENT IN RHESUS MONKEY

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 目的：麻疹减毒活疫苗是非常有效的，尽管母源抗体阻止其在6个月龄之前接种。我们正在研究编码麻疹病毒血凝素、融合蛋白和核蛋白的DNA疫苗保护新生儿免受麻疹的能力。 我们还试图确定导致恒河猴感染和疾病减弱的麻疹病毒突变。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The live, attenuated measles vaccine is very effective, although maternal antibody prevents its administration prior to 6 months of age. We are investigating the ability of a DNA vaccine encoding the measles viral hemaglutinin, fusion and nucleoprotein to protect newborn infants from measles. We are also attempting to define mutations in measles virus that result in attenuated infection and disease in the rhesus monkey.