Advanced Laser Technology for Fractional Skin Resurfacing and Other Surgical Appl

描述(由申请人提供)：该项目的长期目标是创建一种高效、独特和多功能的激光仪器，该仪器将在皮肤科、喉科、耳科和眼科等广泛的外科手术中应用。在短期内，这些仪器将成为几种皮肤科应用中Er：YAG和Er：YSGG激光的有效替代品。第一阶段的两个主要具体目标是：(1)展示一种紧凑型光纤激光仪器，该仪器在理想的波长下发射，具有连续可调的脉冲宽度和高度可控的重复频率，适用于精密的微细部分皮肤表面重塑应用。为此目标的研究设计和方法包括：o构建紧凑而高效的激光二极管泵浦的具有连续可变脉冲持续时间(10 5s-100 ms)的Er：ZBLAN(2.8 5 m)光纤激光器o演示来自超紧凑型高效激光系统(10 mJ脉冲能量为100 5s脉冲，高达500 mJ脉冲能量为100 ms)的适当高脉冲能量o演示可聚焦于尺寸在10 5m和100 5m之间的微光点尺寸的光束质量。(2)贝克曼激光研究所(Univ.使用上述仪器来模拟用Er：YAG激光器观察到的效果，并在宽范围的脉冲持续时间、脉冲突发序列和脉冲重复率上操作，目的是揭示新的临床有益的操作制度。这一目标的研究设计和方法包括：在广泛激光参数下的体外皮肤消融演示使用组织学来量化消融和热损伤，以确定与FDA批准的Er：YAG的等效性。研究了注量、脉冲长度和多次脉冲照射的影响。在第二阶段，我们将：(1)开发扫描系统，改善光束传输。(2)研制了先进的光纤激光器样机。(3)进行体内和临床研究，并证明临床上具有优越的皮肤表面处理效果。 公共卫生相关性：这项研究的主要相关性是，从长远来看，它将导致高效、独特和多功能的激光手术器械，这些器械将在皮肤科、喉科、耳科和眼科等广泛的外科手术中应用。在短期内，这些激光手术设备将成为用于多种皮肤科应用的Er：YAG和Er：YSGG激光的有效替代品。一个关键的优点是，建议的器械将实现更有效和更低的成本的程序，并使手术更快愈合。

DESCRIPTION (provided by applicant): The long-term goal of this project is to create an efficient, unique, and versatile laser instrument that will have applications in a large range of surgical procedures including dermatology, laryngology, otology, and ophthalmology. In the near-term, these instruments will act as efficient replacements for Er:YAG and Er:YSGG lasers used in several dermatological applications. The two major specific aims for Phase I are: (1) Demonstration of a compact fiber laser instrument emitting at an ideal wavelength and with continuously adjustable pulse duration and highly controlled repetition rates for precision micro- fractional skin resurfacing applications. The research design and methods for this aim include: o Construction of a compact and efficient laser-diode-pumped an Er:ZBLAN (2.8 5m) fiber laser with continuously variable pulse durations (10 5s - 100 ms) o Demonstration of appropriately high pulse energies from an ultracompact high efficiency laser system (>10 mJ pulse energies in 100 5s pulses, and up to 500 mJ pulse energies for 100 ms pulses) o Demonstration of a beam quality that can be focused to controlled micro-spot sizes with dimensions between 10 5m and 100 5m (2) Performance of skin resurfacing studies at the Beckman Laser Institute (Univ. of Calif., Irvine) using the above-described instrument, to simulate the effects that are observed with an Er:YAG laser, and operating over a broad range of pulse durations, pulse burst sequences and pulse repetition rates with a goal of uncovering novel clinically-beneficial operating regimes. The research design and methods for this aim include: . Demonstration of ex-vivo skin ablation under a broad range of laser parameters o Use of histology to quantify ablation and thermal damage to determine equivalency with FDA approved Er:YAG. Investigation of the effect of fluence, pulse length and multiple pulse irradiations. In Phase II, we will: (1) Develop scanning system and improve beam delivery. (2) Develop an advanced prototype of our fiber laser instrument. (3) Conduct in vivo and clinical studies and demonstrate clinically superior skin resurfacing effects. PUBLIC HEALTH RELEVANCE: The primary relevance of this research is that it will lead in the long term to efficient, unique, and versatile laser surgical instruments that will have applications in a large range of surgical procedures including dermatology, laryngology, otology, and ophthalmology. In the near-term, these laser surgical instruments will act as efficient replacements for Er:YAG and Er:YSGG lasers used for several dermatological applications. A key advantage is that the proposed instrument will enable more effective and lower cost procedures, and enable quicker healing from the surgery.