Advanced Laser Technology for Fractional Skin Resurfacing and Other Surgical Appl

用于点阵换肤和其他外科手术的先进激光技术

• 批准号: 7911930
• 负责人: Ravinder Jain
• 金额: $ 12.36万
• 依托单位: INFRALASE, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7911930
• 关键词: Ablation; Characteristics; Clinical Research; Clinical Trials; Dermatology; Devices; Dimensions; FDA approved; Fiber; Goals; Healed; Histology; Institutes; Investigation; Lasers; Lead; Length; Methods; Operative Surgical Procedures; Ophthalmology; Otology; Output; Performance; Phase; Physiologic pulse; Procedures; Process; Pump; Research; Research Design; Safety; Scanning; Side; Simulate; Skin; Skin Tissue; Spottings; Surgical Instruments; System; Technology; Thermal Ablation Therapy; Tissues; cost; healing; improved; in vivo; innovation; instrument; irradiation; novel; prototype; public health relevance

DESCRIPTION (provided by applicant): The long-term goal of this project is to create an efficient, unique, and versatile laser instrument that will have applications in a large range of surgical procedures including dermatology, laryngology, otology, and ophthalmology. In the near-term, these instruments will act as efficient replacements for Er:YAG and Er:YSGG lasers used in several dermatological applications. The two major specific aims for Phase I are: (1) Demonstration of a compact fiber laser instrument emitting at an ideal wavelength and with continuously adjustable pulse duration and highly controlled repetition rates for precision micro- fractional skin resurfacing applications. The research design and methods for this aim include: o Construction of a compact and efficient laser-diode-pumped an Er:ZBLAN (2.8 5m) fiber laser with continuously variable pulse durations (10 5s - 100 ms) o Demonstration of appropriately high pulse energies from an ultracompact high efficiency laser system (>10 mJ pulse energies in 100 5s pulses, and up to 500 mJ pulse energies for 100 ms pulses) o Demonstration of a beam quality that can be focused to controlled micro-spot sizes with dimensions between 10 5m and 100 5m (2) Performance of skin resurfacing studies at the Beckman Laser Institute (Univ. of Calif., Irvine) using the above-described instrument, to simulate the effects that are observed with an Er:YAG laser, and operating over a broad range of pulse durations, pulse burst sequences and pulse repetition rates with a goal of uncovering novel clinically-beneficial operating regimes. The research design and methods for this aim include: . Demonstration of ex-vivo skin ablation under a broad range of laser parameters o Use of histology to quantify ablation and thermal damage to determine equivalency with FDA approved Er:YAG. Investigation of the effect of fluence, pulse length and multiple pulse irradiations. In Phase II, we will: (1) Develop scanning system and improve beam delivery. (2) Develop an advanced prototype of our fiber laser instrument. (3) Conduct in vivo and clinical studies and demonstrate clinically superior skin resurfacing effects. PUBLIC HEALTH RELEVANCE: The primary relevance of this research is that it will lead in the long term to efficient, unique, and versatile laser surgical instruments that will have applications in a large range of surgical procedures including dermatology, laryngology, otology, and ophthalmology. In the near-term, these laser surgical instruments will act as efficient replacements for Er:YAG and Er:YSGG lasers used for several dermatological applications. A key advantage is that the proposed instrument will enable more effective and lower cost procedures, and enable quicker healing from the surgery.

描述（由申请人提供）：该项目的长期目标是创造一种高效，独特，多功能的激光仪器，将在广泛的外科手术中应用，包括皮肤科，喉科，耳科和眼科。在短期内，这些仪器将作为Er:YAG和Er:YSGG激光器的有效替代品，用于几种皮肤病学应用。第一阶段的两个主要具体目标是：(1)演示一种紧凑的光纤激光仪器，以理想的波长发射，具有连续可调的脉冲持续时间和高度控制的重复率，用于精确的微分数皮肤表面修复应用。本文的研究设计和方法包括：o构建紧凑高效的激光二极管泵浦Er:ZBLAN （2.8 m）光纤激光器，具有连续可变脉冲持续时间（10 5s - 100 ms） o演示来自超紧凑高效激光系统的适当高脉冲能量（100 5s脉冲能量为10 mJ）；在贝克曼激光研究所（加州大学欧文分校），使用上述仪器进行皮肤表面修复研究，模拟Er:YAG激光器在宽脉冲持续时间范围内观察到的效果。脉冲爆发序列和脉冲重复率的目标是发现新的临床有益的操作方案。本文的研究设计和方法包括：在大范围激光参数下的离体皮肤消融演示o使用组织学量化消融和热损伤，以确定与FDA批准的Er:YAG的等效性。研究了能量通量、脉冲长度和多次脉冲辐照的影响。在第二阶段，我们将：(1)开发扫描系统，改进光束传输。(2)研制出先进的光纤激光仪器样机。(3)进行体内和临床研究，临床表现出优异的皮肤表面修复效果。