CONFOCAL INTEGRATED INSTRUMENT SYSTEM

共焦集成仪器系统

• 批准号: 7793966
• 负责人: Steven Bassnett
• 金额: $ 29.75万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-28 至 2011-07-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7793966
• 关键词: Area; Cancer Center Support Grant; Cataract; Choroidal Neovascularization; Corneal dystrophy; Eye; Eye Infections; Faculty; Funding; Housing; Image; Microscope; National Eye Institute; Ophthalmology; Physiological; Research; Research Personnel; Retinal Degeneration; System; Time; Universities; Washington; fundamental research; in vivo; instrument; instrumentation; member; programs; ranpirnase; tool; vision science

DESCRIPTION (provided by applicant): Confocal imaging is an essential component of modern vision science research. The majority of National Eye Institute (NEI)-funded researchers at Washington University use confocal imaging as an integral and indispensable tool in their research programs. This has led to an unfortunate bottleneck in the research workflow, as too many investigators compete for limited time on an existing instrument. Further, the current instrumentation is configured in such as way as to preclude physiological or in vivo studies, two increasingly important areas of eye research. Funds are requested to purchase an FV1000 CLSM upright confocal microscope. The FV1000 CLSM will be housed in a newly-created Imaging Suite located in the Department of Ophthalmology and Visual Sciences and administered under the auspices of our P30 Vision Science Core grant. The User Group for the new instrument thus includes the 34 faculty members from seven academic departments who are members or affiliates of our P30 Core grant. The new instrument will provide: 1. Much needed additional imaging capacity. 2. Backup in case of downtime of existing instrumentation. 3. Important new functionality. Members of the User Group are engaged in fundamental research into the causes and treatment of retinal degeneration, choroidal neovascularization, herpetic eye infections, cataract and corneal dystrophies. It is expected that the requested instrument will contribute directly and substantively to progress in each of these clinically important areas.

描述（由申请人提供）：共焦成像是现代视觉科学研究的重要组成部分。华盛顿大学的大多数国家眼科研究所（NEI）资助的研究人员使用共焦成像作为其研究计划中不可或缺的工具。这导致了研究工作流程中的一个不幸的瓶颈，因为太多的研究人员在现有仪器上争夺有限的时间。此外，目前的仪器配置的方式，以排除生理或体内研究，眼睛研究的两个越来越重要的领域。需要资金购买一台FV1000 CLSM立式共聚焦显微镜。FV1000 CLSM将被安置在位于眼科和视觉科学系的新创建的成像套件中，并在我们的P30视觉科学核心资助的主持下进行管理。因此，新仪器的用户组包括来自七个学术部门的34名教师，他们是我们P30核心补助金的成员或附属机构。新文书将提供：1.非常需要额外的成像能力。2.现有仪器停机时的备份。3.重要的新功能。用户组的成员从事视网膜变性、脉络膜新生血管、疱疹性眼部感染、白内障和角膜营养不良的病因和治疗的基础研究。预计所要求的工具将直接和实质性地促进这些临床重要领域的进展。