A micro-CT scanner for in vivo mouse imaging and ex vivo monkey tissue imaging

用于小鼠体内成像和猴子离体组织成像的微型 CT 扫描仪

• 批准号: 7793935
• 负责人: ELIOT R SPINDEL
• 金额: $ 34.17万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-20 至 2011-07-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7793935
• 关键词: Advisory Committees; Animals; Area; Automobile Driving; Basic Science; Caliber; Cancer Patient; Cardiovascular system; Cities; Clinical Research; Contract Services; Data Analyses; Developmental Biology; Doctor of Philosophy; Endocrinology; Ensure; Fertility; Fetal Development; Funding; Health; Health Sciences; Hour; Housing; Human; Human Resources; Image; Institution; Lung diseases; Magnetic Resonance Imaging; Metabolic; Minor; Mission; Modeling; Monkeys; Mus; Obesity; Oregon; Physiological; Placental Insufficiency; Pregnancy; Primates; Public Health; Radiology Specialty; Regulation; Reproductive Biology; Research; Research Support; Resolution; Sampling; Scanning; Smoking; System; Time; Tissues; Training; Universities; combat; cost; experience; flexibility; in vivo; instrument; oncology; pre-clinical; prevent; public health relevance

DESCRIPTION (provided by applicant): This is a request for funds to purchase a Skyscan 1066 micro-CT for in vivo mouse imaging and ex vivo monkey tissue imaging at the Oregon National Primate Research Center (ONPRC) and Oregon Health & Science University (OHSU). The mission of the ONPRC is to move from basic science to pre-clinical monkey models to clinical research. As such this scanner which will allow both in vivo scanning of mice and ex vivo scanning of monkey tissues is uniquely suited to the mission of the ONPRC. We evaluated micro-CT scanners from Skyscan, Scanco, GE and Siemens. We chose the Skyscan 1076 because it has the greatest versatility in terms of high resolution (9 microns) and large maximum sample diameter (68 mm) for ex vivo scanning of monkey tissues and flexible resolution, scanning size and physiologic control and gating capacity for in vivo scanning. The research supported by the scanner will support key research areas of the ONPRC including reproductive biology, metabolic regulation, developmental biology and oncology. The scanner will also support cardiovascular research, oncology and endocrinology research by the ONPRC's host institution, OHSU. There will be 5 major users and 6 minor users. The major users will focus on oncofertility, obesity, lung disease and placental insufficiency, all areas of major importance to human health. Use of the system will be directed by a PhD biophysicist who also directs the ONPRC MRI core. A highly experienced small animal radiology technician will oversee day to day use and be responsible for training new users. An advisory committee of users, local, and national micro-CT experts will assist with administration and ensure appropriate training and data analysis. Strong institutional support will provide needed renovations to house the scanner, cover service contract costs and cover personnel costs of the technician and physicist. The scanner will fill a major need as there is no micro-CT scanner in the city of Portland, with the closest scanner located at Oregon State University, two hours driving time from Portland. PUBLIC HEALTH RELEVANCE: This instrument will support research on preserving fertility in cancer patients, research on combating obesity, research on preventing the effects of smoking during pregnancy on fetal development and research on placental problems during pregnancy. These are all major public health problems whose treatment will be significantly helped by the micro-CT scanner requested in this application.

描述（由申请人提供）：这是一份资金申请，用于在俄勒冈州国家灵长类动物研究中心（ONPRC）和俄勒冈州健康与科学大学（OHSU）购买Skyscan 1066微型CT，用于体内小鼠成像和体外猴组织成像。ONPRC的使命是从基础科学到临床前猴子模型再到临床研究。因此，该扫描仪将允许对小鼠进行体内扫描和对猴组织进行离体扫描，其独特地适合于ONPRC的使命。我们评估了Skyscan、Sundio、GE和Siemens的微型CT扫描仪。我们选择了Skyscan 1076，因为它在高分辨率（9微米）和大的最大样品直径（68 mm）方面具有最大的通用性，用于猴组织的离体扫描，以及灵活的分辨率，扫描尺寸和生理控制以及体内扫描的门控能力。扫描仪支持的研究将支持ONPRC的关键研究领域，包括生殖生物学，代谢调节，发育生物学和肿瘤学。该扫描仪还将支持ONPRC主办机构OHSU的心血管研究，肿瘤学和内分泌学研究。将有5个主要用户和6个次要用户。主要用户将集中在肿瘤生育、肥胖、肺病和胎盘功能不全，所有这些领域对人类健康都非常重要。该系统的使用将由一名生物药理学博士指导，该博士还指导ONPRC MRI核心。一位经验丰富的小动物放射学技术人员将监督日常使用，并负责培训新用户。一个由用户、地方和国家微型CT专家组成的咨询委员会将协助管理，并确保适当的培训和数据分析。强有力的机构支助将提供所需的翻修，以安置扫描仪，支付服务合同费用，并支付技术员和物理学家的人事费。该扫描仪将填补一个主要的需求，因为没有微型CT扫描仪在波特兰市，与最近的扫描仪位于俄勒冈州州立大学，两个小时的车程从波特兰。 公共卫生关系：该工具将支持关于保持癌症患者生育能力的研究、关于防治肥胖症的研究、关于防止怀孕期间吸烟对胎儿发育的影响的研究以及关于怀孕期间胎盘问题的研究。这些都是主要的公共卫生问题，本申请中要求的微型CT扫描仪将大大有助于这些问题的治疗。