A MICRO-CT SCANNER FOR IN VIVO MOUSE IMAGING AND EX VIVO MONKEY TISSUE IMAGING

该子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心拨款提供。次级项目的主要支助 子项目的主要研究者可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 表示子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 这是一个赠款购买微型CT扫描仪在体内小鼠成像和离体猴子组织成像。ONPRC的使命是从基础科学到临床前猴子模型再到临床研究。因此，该扫描仪将允许对小鼠进行体内扫描和对猴组织进行离体扫描，其独特地适合于ONPRC的使命。扫描仪支持的研究将支持ONPRC的关键研究领域，包括生殖生物学，代谢调节，发育生物学和肿瘤学。将有5个主要用户和6个次要用户。主要用户将集中在肿瘤生育、肥胖、肺病和胎盘功能不全，所有这些领域对人类健康都非常重要。该系统的使用将由一名生物药理学博士指导，该博士还指导ONPRC MRI核心。一位经验丰富的小动物放射学技术人员将监督日常使用，并负责培训新用户。一个由用户、地方和国家微型CT专家组成的咨询委员会将协助管理，并确保适当的培训和数据分析。该扫描仪将填补一个主要的需求，因为没有微型CT扫描仪在波特兰市，与最近的扫描仪位于俄勒冈州州立大学，两个小时的车程从波特兰。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This is a grant to purchase a micro-CT scanner for in vivo mouse imaging and ex vivo monkey tissue imaging at the. The mission of the ONPRC is to move from basic science to pre-clinical monkey models to clinical research. As such this scanner which will allow both in vivo scanning of mice and ex vivo scanning of monkey tissues is uniquely suited to the mission of the ONPRC. The research supported by the scanner will support key research areas of the ONPRC including reproductive biology, metabolic regulation, developmental biology and oncology. There will be 5 major users and 6 minor users. The major users will focus on oncofertility, obesity, lung disease and placental insufficiency, all areas of major importance to human health. Use of the system will be directed by a PhD biophysicist who also directs the ONPRC MRI core. A highly experienced small animal radiology technician will oversee day to day use and be responsible for training new users. An advisory committee of users, local, and national micro-CT experts will assist with administration and ensure appropriate training and data analysis. The scanner will fill a major need as there is no micro-CT scanner in the city of Portland, with the closest scanner located at Oregon State University, two hours driving time from Portland.