Hamamatsu FDSS7000 Functional HTS Drug Screening System

描述(由申请人提供)：堪萨斯大学(KU)的高通量筛选核心设施(HTSC)寻求获得Hamamatsu FDSS 7000功能性药物发现筛选系统，这是一种新型的基于成像的平板阅读器，具有荧光和发光能力，用于离子通道和G蛋白偶联受体(GPCRs)研究。一些疾病状态与离子通道和GPCRs功能障碍有关，基于图像的平板阅读器已成为这一研究领域的行业标准。目前，KU Lawrence校区和堪萨斯城医疗中心的教员没有能力进行FDSS7000提供的尖端、GPCR和离子通道研究，因为在堪萨斯州或邻近的密苏里州、俄克拉何马州和内布拉斯加州都没有这样的仪器。KUHTSC凭借其卓越的行业经验和开放的服务政策，在学术HTS中心中取得了全国领先地位。来自美国心脏地带机构的许多研究人员依赖KUHTSC提供关键研究和筛选支持。FDSS 7000将对那些研究不一定也需要HTS的教职员工提供很大的帮助。KUHTSL帮助研究人员进行分析开发和高通量筛选。核心设施作为研究人员的教育资源，提供必要的HTS技术和实验培训。 收购FDSS7000系统将支持我们为堪萨斯州多个院系和校园的研究人员开发新的生物分析方法的持续努力，这些研究小组涉及大量不同的研究小组。它还将推动现有的项目进入积极的药物发现计划，包括对化合物库进行高通量筛选。这一核心工作站将使堪萨斯州的研究人员在获得外部资金方面变得更加有竞争力。此次收购将补充我们的目标，即持续协调努力，在堪萨斯州学术校园加强与生物科学相关的多学科基础研究。这一系统将有助于雇用具有创新研究项目的聪明的新调查人员。这项应用的广泛、长期目标包括多个KU和KUMC教员围绕FDSS 7000系统提供的技术开发新项目的研究计划。我们对HTS核心设施的愿景为KU蓬勃发展的研究企业提供了一条途径，并有助于吸引和培养KU和其他堪萨斯州州立大学的顶尖研究人才。

DESCRIPTION (provided by applicant): The High Throughput Screening Core Facility (HTSC) at the University of Kansas (KU) seeks to acquire a Hamamatsu FDSS 7000 functional drug discovery screening system, a novel imaging based plate reader with fluorescent and luminescent capabilities for use in ion channel and G protein coupled receptor (GPCRs) research. Several disease states are related to dysfunction in ion channels and GPCRs, and image based plate readers have become the industry standard for use in this area of research. At present, faculty at the KU Lawrence campus and the Medical Center in Kansas City do not have the ability to conduct cutting edge, GPCR and ion channel research afforded by the FDSS7000, as no such instrumentation is available anywhere in the state of Kansas, or in the neighboring states of Missouri, Oklahoma and Nebraska. KUHTSC has achieved national prominence among academic HTS centers because of its eminent staff with industrial experience and open service policy. A number of researchers from institutions across the Heartland of America depend on the KUHTSC to provide critical research and screening support. The FDSS 7000 would be of great assistance to faculty whose research does not necessarily require HTS as well. KUHTSL aids researchers in assay development and high through put screening. The core facility serves as an educational resource for researchers, providing needed training in HTS technology and experimentation. Acquisition of the FDSS7000 system would bolster our ongoing efforts in developing novel methods of biological analysis for Kansas researchers in multiple departments and campuses across a substantial diversity of research groups. It would also propel existing projects into active drug discovery programs involving high throughput screening of compound libraries. This core workstation will enable Kansas researchers to become significantly more competitive for external funding. This acquisition would complement our goals of a sustained coordinated effort to enhance multidisciplinary basic research related to the biological sciences across academic Kansas campuses. This system will help facilitate the hiring of bright, new investigators with innovative research projects. The broad, long term objectives of this application include research plans by multiple KU and KUMC faculty to develop novel projects around the technology afforded by the FDSS 7000 system. Our vision for the HTS core facility provides an avenue for a thriving research enterprise at KU, and helps in attracting and cultivating top research talent at KU and other Kansas State institutions.