Hamamatsu FDSS7000 Functional HTS Drug Screening System

Hamamatsu FDSS7000 功能性 HTS 药物筛选系统

• 批准号: 7793861
• 负责人: Munirathnam K Chaguturu
• 金额: $ 49.9万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-16 至 2011-06-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7793861
• 关键词: Americas; Area; Basic Science; Biological; Biological Sciences; Cities; Complement; Core Facility; Disease; Faculty; Functional disorder; Funding; G Protein-Coupled Receptor Genes; G-Protein-Coupled Receptors; Goals; Image; Industry; Institution; Ion Channel; Kansas; Libraries; Medical center; Methods; Missouri; Nebraska; Oklahoma; Policies; Preclinical Drug Evaluation; Reader; Research; Research Personnel; Research Project Grants; Resources; Screening procedure; Services; System; Talents; Technology; Training; Universities; Vision; assay development; base; drug discovery; experience; high throughput screening; innovation; instrumentation; multidisciplinary; novel; programs

DESCRIPTION (provided by applicant): The High Throughput Screening Core Facility (HTSC) at the University of Kansas (KU) seeks to acquire a Hamamatsu FDSS 7000 functional drug discovery screening system, a novel imaging based plate reader with fluorescent and luminescent capabilities for use in ion channel and G protein coupled receptor (GPCRs) research. Several disease states are related to dysfunction in ion channels and GPCRs, and image based plate readers have become the industry standard for use in this area of research. At present, faculty at the KU Lawrence campus and the Medical Center in Kansas City do not have the ability to conduct cutting edge, GPCR and ion channel research afforded by the FDSS7000, as no such instrumentation is available anywhere in the state of Kansas, or in the neighboring states of Missouri, Oklahoma and Nebraska. KUHTSC has achieved national prominence among academic HTS centers because of its eminent staff with industrial experience and open service policy. A number of researchers from institutions across the Heartland of America depend on the KUHTSC to provide critical research and screening support. The FDSS 7000 would be of great assistance to faculty whose research does not necessarily require HTS as well. KUHTSL aids researchers in assay development and high through put screening. The core facility serves as an educational resource for researchers, providing needed training in HTS technology and experimentation. Acquisition of the FDSS7000 system would bolster our ongoing efforts in developing novel methods of biological analysis for Kansas researchers in multiple departments and campuses across a substantial diversity of research groups. It would also propel existing projects into active drug discovery programs involving high throughput screening of compound libraries. This core workstation will enable Kansas researchers to become significantly more competitive for external funding. This acquisition would complement our goals of a sustained coordinated effort to enhance multidisciplinary basic research related to the biological sciences across academic Kansas campuses. This system will help facilitate the hiring of bright, new investigators with innovative research projects. The broad, long term objectives of this application include research plans by multiple KU and KUMC faculty to develop novel projects around the technology afforded by the FDSS 7000 system. Our vision for the HTS core facility provides an avenue for a thriving research enterprise at KU, and helps in attracting and cultivating top research talent at KU and other Kansas State institutions.

描述（由申请人提供）：堪萨斯大学（KU）的高通量筛选核心设施（HTSC）寻求获得Hamamatsu FDSS 7000功能性药物发现筛选系统，该系统是一种新型的基于成像的酶标仪，具有荧光和发光能力，可用于离子通道和G蛋白偶联受体（GPCR）研究。几种疾病状态与离子通道和GPCR的功能障碍有关，基于图像的酶标仪已成为该研究领域的行业标准。目前，在KU劳伦斯校区和医学中心在堪萨斯城的教师没有进行尖端，GPCR和离子通道的FDSS 7000提供的研究能力，因为没有这样的仪器可在任何地方在堪萨斯州，或在邻近的密苏里州，俄克拉荷马州和内布拉斯加州。KUHTSC在学术HTS中心中取得了全国性的突出地位，因为其杰出的工作人员具有行业经验和开放的服务政策。来自美国中部地区机构的许多研究人员依靠KUHTSC提供关键研究和筛选支持。FDSS 7000将对那些研究不一定需要HTS的教师有很大的帮助。KUHTSL帮助研究人员进行检测开发和高通量筛选。核心设施作为研究人员的教育资源，提供HTS技术和实验所需的培训。 收购FDSS 7000系统将加强我们在开发新的生物分析方法，为堪萨斯研究人员在多个部门和校园在一个相当大的多样性的研究小组正在进行的努力。它还将推动现有项目进入涉及化合物库高通量筛选的积极药物发现计划。这一核心工作站将使堪萨斯的研究人员在争取外部资金方面更具竞争力。此次收购将补充我们持续协调努力的目标，以加强整个堪萨斯学术园区与生物科学相关的多学科基础研究。这一制度将有助于聘用具有创新研究项目的聪明的新研究人员。该应用程序的广泛，长期目标包括多个KU和KUMC教师的研究计划，以围绕FDSS 7000系统提供的技术开发新项目。我们对HTS核心设施的愿景为KU蓬勃发展的研究企业提供了一条途径，并有助于吸引和培养KU和其他堪萨斯州立机构的顶尖研究人才。