HIGH THROUGHPUT SCREENING
高通量筛选
基本信息
- 批准号:8364921
- 负责人:
- 金额:$ 14.67万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-06-01 至 2012-05-31
- 项目状态:已结题
- 来源:
- 关键词:Applications GrantsAreaBiochemicalBiological AssayCancer CenterCell Culture TechniquesCellsCitiesCommunitiesComplexConsultationsDataData AnalysesEnd Point AssayFoundationsFundingGoalsGrantHuman ResourcesInstitutesInstitutionKansasKineticsLabelLaboratoriesMedical centerMicroscopyMissouriMyelinNational Center for Research ResourcesNebraskaPrincipal InvestigatorRegenerative MedicineResearchResearch InfrastructureResearch PersonnelResearch Project GrantsResourcesScreening procedureServicesSmall Interfering RNASourceTherapeuticUnited StatesUnited States National Institutes of HealthUniversitiesassay developmentbasecostdata miningdrug discoveryexperienceforesthigh throughput screeninginstrumentationtool
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
The primary goal of the High Throughput Screening Core (HTS) at the University of Kansas (KU) has been to make modern drug discovery tools available to biomedical researchers in the Greater Kansas City area, Kansas and beyond. The modern 4,500 sq. ft. HTS research/office complex is fully equipped with state-of-the-art instrumentation, and includes separate cell culture laboratories as well as a high content screening microscopy laboratory. Personnel have extensive experience in executing cell-based, biochemical, label-free, siRNA as well as high content screening campaigns. The HTS Core assists the drug discovery research community, from assay development to screening to compound profiling and data mining. The instrumentation available in the HTS Core allows us to screen about 100,000 compounds in two days for end point assays, or one week for kinetic assays. We have supported investigators not only from KU and the KU Medical Center, but also from Kansas State University, the University of Missouri, the University of Nebraska and several other institutions in the United States. We are also supporting drug discovery research efforts at non-academia, such as Eli Lilly, InVitria, Wake Forest Institute for Regenerative Medicine and Myelin research Foundation.
Over the years, we have provided services for several research projects involving assay development, high throughput screening and data analyses. The HTS Core provides pilot data in support of grant applications by the investigators. At present, the HTS Core is even more actively engaged in advancing drug discovery projects within KU as evidenced by the growing number of active projects and consultations on HTS-ready assay development.
这个子项目是许多利用资源的研究子项目之一
由NIH/NCRR资助的中心拨款提供。子项目的主要支持
而子项目的主要调查员可能是由其他来源提供的,
包括其他NIH来源。 列出的子项目总成本可能
代表子项目使用的中心基础设施的估计数量,
而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。
堪萨斯大学(KU)的高重复筛选核心(HTS)的主要目标是为大堪萨斯城地区、堪萨斯及其他地区的生物医学研究人员提供现代药物发现工具。现代化的4,500平方米英尺HTS研究/办公大楼配备了最先进的仪器,包括独立的细胞培养实验室以及高含量的筛选显微镜实验室。工作人员在执行基于细胞的、生物化学的、无标记的、siRNA以及高含量筛选活动方面具有丰富的经验。HTS核心协助药物发现研究社区,从分析开发到筛选,再到化合物分析和数据挖掘。HTS Core中可用的仪器允许我们在两天内筛选约100,000种化合物用于终点测定,或在一周内进行动力学测定。我们不仅支持KU和KU医学中心的研究人员,还支持来自堪萨斯州立大学、密苏里州大学、内布拉斯加大学和美国其他几个机构的研究人员。我们还支持非学术机构的药物发现研究工作,如Eli Lilly、InVitria、维克森林再生医学研究所和髓磷脂研究基金会。
多年来,我们为多个研究项目提供服务,包括检测开发、高通量筛选和数据分析。HTS核心提供试点数据,以支持研究人员的赠款申请。 目前,HTS核心更加积极地参与推进KU内的药物发现项目,这一点可以从越来越多的活跃项目和关于HTS就绪检测开发的咨询中得到证明。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Munirathnam K Chaguturu其他文献
Munirathnam K Chaguturu的其他文献
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{{ truncateString('Munirathnam K Chaguturu', 18)}}的其他基金
Hamamatsu FDSS7000 Functional HTS Drug Screening System
Hamamatsu FDSS7000 功能性 HTS 药物筛选系统
- 批准号:
7793861 - 财政年份:2010
- 资助金额:
$ 14.67万 - 项目类别:
COBRE: UKS: CORE B: HIGH THROUGHPUT SCREENING & TARGET IDENTIFICATION
COBRE:UKS:核心 B:高通量筛选
- 批准号:
7959396 - 财政年份:2009
- 资助金额:
$ 14.67万 - 项目类别:
COBRE: UKS: CORE B: HIGH THROUGHPUT SCREENING & TARGET IDENTIFICATION
COBRE:UKS:核心 B:高通量筛选
- 批准号:
7720080 - 财政年份:2008
- 资助金额:
$ 14.67万 - 项目类别:
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