Cu-64 Solid Target Handling System

Cu-64 固体靶处理系统

• 批准号: 7791866
• 负责人: Simon R Cherry
• 金额: $ 39.25万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-25 至 2011-03-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7791866
• 关键词: Animal Model; Antibodies; Cell Therapy; Cells; Copper; Core Facility; Cyclotrons; Development; Diagnostic; Faculty; Funding; Genomics; Goals; Half-Life; Housing; Image; Imagery; Isotopes; Kinetics; Label; Liposomes; Molecular; Monitor; Pathway interactions; Patients; Peptides; Perfusion; Positron-Emission Tomography; Production; Radioisotopes; Radiolabeled; Research; Research Infrastructure; Research Personnel; Research Project Grants; Secure; Solid; Source; Stem cells; System; Technology; Therapeutic Agents; Tracer; Transportation; United States National Institutes of Health; base; gene therapy; in vivo; interest; molecular imaging; nanoparticle; novel diagnostics; novel strategies; pre-clinical; programs; public health relevance; radiotracer; stem

DESCRIPTION (provided by applicant): The goal of this proposal is to secure funding to add a 64Cu targetry and handling system to a RDS 111 biomedical cyclotron to enable routine production of the radionuclide 64Cu for in vivo molecular imaging studies. The cyclotron and the proposed targetry system are housed in the Center for Molecular and Genomic Imaging, a preclinical core facility at UC Davis that provides the infrastructure and expertise to conduct in vivo imaging studies in animal models. 64Cu-labeled biomolecules, including 64Cu-PTSM (for perfusion and cell labeling), 64Cu-labeled peptides, 64Cu-labeled antibodies, 64Cu-labeled nanoparticles and 64Cu-labeled liposomes, are being used by a large group of NIH-funded faculty at UC Davis as the basis for the development of new diagnostic and therapeutic agents. Commercial sources for 64Cu only deliver once every 14 days, and large fractions of the activity are lost in transportation. Thus, NIH-funded research is limited by 64Cu availability. We propose the addition of a 64Cu target and target handling system that will enable routine production of 64Cu on our existing RDS 111 cyclotron, providing 64Cu on a regular basis for twelve NIH-funded researchers who utilize 64Cu in their research programs. PUBLIC HEALTH RELEVANCE: The field of molecular imaging seeks to discover new approaches to imaging specific biologic targets and pathways in vivo, with the ultimate goal of providing patient-specific and molecularly-based diagnostic information. In addition, molecular imaging approaches are being developed to directly monitor molecularly targeted therapies, cellular therapies and gene therapies. Positron emission tomography using radiolabeled tracers is a key platform technology for molecular imaging. The radionuclide copper-64 has a half-life compatible with the kinetics of many interesting biomolecules and is therefore an isotope with broad applications in the field. This proposal will enable routine production of copper-64 at UC Davis for application to research projects funded by NIH that involve the development of new diagnostic and therapeutic agents, and for tracking and visualization of stem and progenitor cell therapies.

描述(由申请人提供)：这项提案的目标是获得资金，在RDS 111生物医学回旋加速器上增加一个64Cu靶标和处理系统，以便能够为活体分子成像研究常规生产放射性核素64Cu。回旋加速器和拟议的靶向系统位于分子和基因组成像中心，该中心是加州大学戴维斯分校的临床前核心设施，为在动物模型中进行活体成像研究提供基础设施和专业知识。64铜标记的生物分子，包括64铜标记的生物分子(用于灌注和细胞标记)、64铜标记的多肽、64铜标记的抗体、64铜标记的纳米颗粒和64铜标记的脂质体，正被加州大学戴维斯分校的一大群NIH资助的教职员工用作开发新的诊断和治疗药物的基础。商业来源的64铜每14天才交货一次，很大一部分活动在运输过程中损失。因此，美国国立卫生研究院资助的研究受到64铜可获得性的限制。我们建议增加一个64Cu靶和靶处理系统，使我们现有的RDS 111回旋加速器能够常规生产64Cu，为12名在他们的研究计划中使用64Cu的NIH资助的研究人员定期提供64Cu。 与公共卫生相关：分子成像领域寻求发现新的方法来成像体内特定的生物靶点和途径，最终目标是提供患者特定的和基于分子的诊断信息。此外，正在开发分子成像方法来直接监测分子靶向治疗、细胞治疗和基因治疗。使用放射性标记示踪剂的正电子发射断层扫描是分子成像的关键平台技术。放射性核素铜-具有与许多有趣的生物分子动力学相容的半衰期，因此是一种在该领域具有广泛应用的同位素。这项提议将使加州大学戴维斯分校的铜-常规生产得以应用于由美国国立卫生研究院资助的研究项目，这些项目涉及开发新的诊断和治疗试剂，并用于跟踪和可视化干细胞和祖细胞疗法。