Small-Animal Optical Imaging System
小动物光学成像系统
基本信息
- 批准号:8246790
- 负责人:
- 金额:$ 40.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-05-08 至 2013-05-07
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAnesthesia proceduresAnimal ModelAnimalsAreaAtherosclerosisBackBiochemicalBiological SciencesCellsComputer softwareCore FacilityDetectionDevelopmentDiagnosticDrug Delivery SystemsFluorescenceFundingGenomicsGoalsHeatingImageImaging TechniquesInflammationInstitutionLightLuciferasesMalignant NeoplasmsMeasurementMolecularRadiopharmaceuticalsReporter GenesResearchResearch InfrastructureSecureSignal TransductionSourceSystemTechnologyTherapeuticTissuesUnited States National Institutes of HealthWound Healingbasecharge coupled device cameradata acquisitionhuman diseaseimaging probein vivomolecular imagingnoveloptical imagingtherapeutic developmenttransmission process
项目摘要
DESCRIPTION (provided by applicant): The goal of this proposal is to secure funding to add an IVIS Spectrum optical imaging system to the Center for Molecular and Genomic Imaging, a core facility at UC Davis that provides the infrastructure and expertise to conduct in vivo imaging
studies in animal models. The IVIS Spectrum (Caliper Life Sciences) will be used for in vivo imaging studies of cells and tissues carrying luciferase or fluorescent reporter genes, and animals injected with fluorescent imaging agents or radiopharmaceuticals, the latter being studied by the emission of Cerenkov light. The IVIS Spectrum system can be used in both reflectance and transmission mode and includes a highly sensitive back-thinned, back-illuminated grade 1 CCD camera, a broad band excitation source with filters for fluorescence measurements, selectable filters for multispectral detection, a heated enclosure with anesthesia supply, and software to control data acquisition, for spectral unmixing, 3-D signal localization and quantification, and image display and analysis. The system will be placed in our core facility and used to support and aid NIH-funded research in diverse areas such as cancer, atherosclerosis, wound healing, and inflammation, and in a large body of research to evaluate targeted molecular imaging probe and therapeutic development, as well as drug delivery technologies. The system also will serve as the platform for further development and application of novel Cerenkov imaging techniques being developed at our institution. In summary, this system will directly support the development of new targeted diagnostic and therapeutic strategies, as well as to characterize and better understand the molecular and biochemical basis of normal and diseased tissue in animal models of human disease.
PUBLIC HEALTH RELEVANCE: The field of molecular imaging seeks to discover new approaches to imaging specific biologic targets and pathways in vivo, with the ultimate goal of providing patient-specific and molecularly-based diagnostic information. In addition, molecular imaging approaches are being developed to directly monitor molecularly targeted therapies, cellular therapies and gene therapies. The proposed IVIS Spectrum instrument will be used to study the spatial and temporal distribution of fluorescent molecules, particles, and optical (bioluminescent and fluorescent) reporter proteins in the whole animal. This provides a powerful platform for characterizing animal disease models and non-invasively determining the efficacy of new diagnostic and therapeutic strategies in preclinical models prior to translation to the clinic.
描述(由申请人提供):本提案的目标是获得资金,为分子和基因组成像中心增加IVIS光谱光学成像系统,该中心是加州大学戴维斯分校的核心设施,提供进行体内成像的基础设施和专业知识
动物模型的研究。IVIS Spectrum(Caliper Life Sciences)将用于携带荧光素酶或荧光报告基因的细胞和组织以及注射荧光成像剂或放射性药物的动物的体内成像研究,后者通过发射Cerenkov光进行研究。IVIS Spectrum系统可用于反射和透射模式,包括一个高灵敏度的背照式1级CCD相机、一个带荧光测量滤光片的宽带激发源、用于多光谱检测的可选滤光片、一个带麻醉供应的加热外壳以及用于控制数据采集的软件,用于光谱分解、3-D信号定位和定量,以及图像显示和分析。该系统将被放置在我们的核心设施中,用于支持和帮助NIH资助的癌症、动脉粥样硬化、伤口愈合和炎症等不同领域的研究,以及评估靶向分子成像探针和治疗开发以及药物输送技术的大量研究。该系统还将作为进一步开发和应用我们机构正在开发的新型切伦科夫成像技术的平台。总之,该系统将直接支持新的靶向诊断和治疗策略的开发,以及表征和更好地理解人类疾病动物模型中正常和患病组织的分子和生化基础。
公共卫生关系:分子成像领域寻求发现体内成像特定生物靶点和途径的新方法,最终目标是提供患者特异性和基于分子的诊断信息。此外,正在开发分子成像方法以直接监测分子靶向治疗、细胞治疗和基因治疗。拟议的IVIS光谱仪器将用于研究整个动物中荧光分子、颗粒和光学(生物发光和荧光)报告蛋白的空间和时间分布。这提供了一个强大的平台,用于表征动物疾病模型,并在临床前模型中非侵入性地确定新诊断和治疗策略的有效性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Simon R Cherry其他文献
Functional whole-brain imaging in behaving rodents
行为啮齿动物的功能性全脑成像
- DOI:
10.1038/nmeth0411-301 - 发表时间:
2011-03-30 - 期刊:
- 影响因子:32.100
- 作者:
Simon R Cherry - 通讯作者:
Simon R Cherry
New PET technologies – embracing progress and pushing the limits
- DOI:
10.1007/s00259-021-05390-4 - 发表时间:
2021-06-03 - 期刊:
- 影响因子:7.600
- 作者:
Nicolas Aide;Charline Lasnon;Adam Kesner;Craig S Levin;Irene Buvat;Andrei Iagaru;Ken Hermann;Ramsey D Badawi;Simon R Cherry;Kevin M Bradley;Daniel R McGowan - 通讯作者:
Daniel R McGowan
Simon R Cherry的其他文献
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{{ truncateString('Simon R Cherry', 18)}}的其他基金
Development of PET imaging biomarkers to predict enhanced glioblastoma radiotherapy by a novel H-NOX oxygen carrier
开发 PET 成像生物标志物来预测新型 H-NOX 氧载体增强的胶质母细胞瘤放疗
- 批准号:
9240463 - 财政年份:2017
- 资助金额:
$ 40.75万 - 项目类别:
Research at the interface of optical and ionizing radiation for innovative cancer imaging and therapy
用于创新癌症成像和治疗的光学和电离辐射界面研究
- 批准号:
9115570 - 财政年份:2015
- 资助金额:
$ 40.75万 - 项目类别:
Research at the interface of optical and ionizing radiation for innovative cancer imaging and therapy
用于创新癌症成像和治疗的光学和电离辐射界面研究
- 批准号:
10242140 - 财政年份:2015
- 资助金额:
$ 40.75万 - 项目类别:
Innovative Silicon Photomultiplier Technologies for Small-Animal PET
用于小动物 PET 的创新硅光电倍增技术
- 批准号:
9287788 - 财政年份:2015
- 资助金额:
$ 40.75万 - 项目类别:
Photodynamic Therapy Mediated by Cerenkov Light Emitted from Radiopharmaceut
放射性药物发出的切伦科夫光介导的光动力疗法
- 批准号:
8702867 - 财政年份:2014
- 资助金额:
$ 40.75万 - 项目类别:
A cost-effective high-performance ceramic garnet scintillator for PET
用于 PET 的经济高效的高性能陶瓷石榴石闪烁体
- 批准号:
8435109 - 财政年份:2012
- 资助金额:
$ 40.75万 - 项目类别:
A cost-effective high-performance ceramic garnet scintillator for PET
用于 PET 的经济高效的高性能陶瓷石榴石闪烁体
- 批准号:
8721957 - 财政年份:2012
- 资助金额:
$ 40.75万 - 项目类别:
Quantitative Evaluation of Cerenkov Luminescence for Imaging and Therapy
用于成像和治疗的切伦科夫发光的定量评估
- 批准号:
8342753 - 财政年份:2012
- 资助金额:
$ 40.75万 - 项目类别:
A cost-effective high-performance ceramic garnet scintillator for PET
用于 PET 的经济高效的高性能陶瓷石榴石闪烁体
- 批准号:
8554763 - 财政年份:2012
- 资助金额:
$ 40.75万 - 项目类别: