Innovative Silicon Photomultiplier Technologies for Small-Animal PET

用于小动物 PET 的创新硅光电倍增技术

基本信息

  • 批准号:
    9287788
  • 负责人:
  • 金额:
    $ 35.33万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-07-01 至 2019-04-30
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Preclinical positron emission tomography (PET) has become a widely used tool in biomedical research, particularly in the evaluation of new therapeutics. Hundreds of scanners are installed across the world in major medical research centers and within pharmaceutical companies. For a variety of reasons, however, the performance of these systems falls well short of what can theoretically be achieved. This has two important consequences. Firstly, the quantitative potential of current studies of radiopharmaceutical kinetics and uptake is undermined by limited spatial resolution (reducing accuracy) and limited sensitivity (reducing precision). Secondly, important applications for preclinical PET, for example metabolic imaging in gray matter structures in the mouse brain or studies of low abundance protein targets, such as TSPO receptor expression in chronic inflammation, are just out of the reach of current instruments. The goal of this proposal is to develop a pathway towards small-animal PET scanners that can come as close as possible to the theoretical limits of spatial resolution and sensitivity imposed by fundamental physics and the properties of available detector materials. Building on 15 years of development of increasingly high resolution detectors for small-animal PET, recent advances in realizing dual-ended detectors that can also simultaneously provide high sensitivity and combining these with highly innovative silicon photomultiplier (SiPM) photodetectors, we propose a design that will lead to detector modules with unprecedented performance for small-animal PET applications. Specifically, we will develop fully-engineered detector modules suitable for close packing in a preclinical PET scanner geometry that will support better than 0.6 mm reconstructed spatial resolution, an average sensitivity of >10% across the whole body of a mouse, depth-of-interaction resolution < 3 mm, timing resolution < 3 ns and energy resolution < 30%. We will develop the electronics and software to efficiently read out these modules with no significant degradation in performance and integrate them into the open source OpenPET libraries for access by the entire nuclear medical imaging community. Lastly, we will use experimental data from fully-engineered detector modules combined with advanced simulation tools to design and predict the performance of a preclinical scanner using our new technology. The outcome of this proposal will be detector modules and a scanner design that advance preclinical PET to new levels of spatial resolution and sensitivity together with the comprehensive set of experimental and simulation data that will be needed to justify moving to the next stage of developing a prototype small-animal PET scanner. There also will be a broader impact in that the detector technology and electronics developed will be applicable to other PET systems, especially dedicated organ imaging (e.g. brain, breast) scanners and PET/MR systems.


项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Simon R Cherry其他文献

Functional whole-brain imaging in behaving rodents
行为啮齿动物的功能性全脑成像
  • DOI:
    10.1038/nmeth0411-301
  • 发表时间:
    2011-03-30
  • 期刊:
  • 影响因子:
    32.100
  • 作者:
    Simon R Cherry
  • 通讯作者:
    Simon R Cherry
New PET technologies – embracing progress and pushing the limits
  • DOI:
    10.1007/s00259-021-05390-4
  • 发表时间:
    2021-06-03
  • 期刊:
  • 影响因子:
    7.600
  • 作者:
    Nicolas Aide;Charline Lasnon;Adam Kesner;Craig S Levin;Irene Buvat;Andrei Iagaru;Ken Hermann;Ramsey D Badawi;Simon R Cherry;Kevin M Bradley;Daniel R McGowan
  • 通讯作者:
    Daniel R McGowan

Simon R Cherry的其他文献

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{{ truncateString('Simon R Cherry', 18)}}的其他基金

Development of PET imaging biomarkers to predict enhanced glioblastoma radiotherapy by a novel H-NOX oxygen carrier
开发 PET 成像生物标志物来预测新型 H-NOX 氧载体增强的胶质母细胞瘤放疗
  • 批准号:
    9240463
  • 财政年份:
    2017
  • 资助金额:
    $ 35.33万
  • 项目类别:
Research at the interface of optical and ionizing radiation for innovative cancer imaging and therapy
用于创新癌症成像和治疗的光学和电离辐射界面研究
  • 批准号:
    9115570
  • 财政年份:
    2015
  • 资助金额:
    $ 35.33万
  • 项目类别:
Research at the interface of optical and ionizing radiation for innovative cancer imaging and therapy
用于创新癌症成像和治疗的光学和电离辐射界面研究
  • 批准号:
    10242140
  • 财政年份:
    2015
  • 资助金额:
    $ 35.33万
  • 项目类别:
Photodynamic Therapy Mediated by Cerenkov Light Emitted from Radiopharmaceut
放射性药物发出的切伦科夫光介导的光动力疗法
  • 批准号:
    8702867
  • 财政年份:
    2014
  • 资助金额:
    $ 35.33万
  • 项目类别:
A cost-effective high-performance ceramic garnet scintillator for PET
用于 PET 的经济高效的高性能陶瓷石榴石闪烁体
  • 批准号:
    8435109
  • 财政年份:
    2012
  • 资助金额:
    $ 35.33万
  • 项目类别:
Tomographic X-Ray Microscope System
X射线断层显微镜系统
  • 批准号:
    8246978
  • 财政年份:
    2012
  • 资助金额:
    $ 35.33万
  • 项目类别:
Small-Animal Optical Imaging System
小动物光学成像系统
  • 批准号:
    8246790
  • 财政年份:
    2012
  • 资助金额:
    $ 35.33万
  • 项目类别:
A cost-effective high-performance ceramic garnet scintillator for PET
用于 PET 的经济高效的高性能陶瓷石榴石闪烁体
  • 批准号:
    8721957
  • 财政年份:
    2012
  • 资助金额:
    $ 35.33万
  • 项目类别:
Quantitative Evaluation of Cerenkov Luminescence for Imaging and Therapy
用于成像和治疗的切伦科夫发光的定量评估
  • 批准号:
    8342753
  • 财政年份:
    2012
  • 资助金额:
    $ 35.33万
  • 项目类别:
A cost-effective high-performance ceramic garnet scintillator for PET
用于 PET 的经济高效的高性能陶瓷石榴石闪烁体
  • 批准号:
    8554763
  • 财政年份:
    2012
  • 资助金额:
    $ 35.33万
  • 项目类别:

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物理和生物模型的非局部变分问题
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