Research at the interface of optical and ionizing radiation for innovative cancer imaging and therapy

用于创新癌症成像和治疗的光学和电离辐射界面研究

• 批准号: 10242140
• 负责人: Simon R Cherry
• 金额: $ 71.23万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10242140
• 关键词: Animal Model; Area; Biological Assay; Cancer Biology; Cancer Intervention; Cancer Patient; Detection; Development; Diagnosis; Diagnostic Neoplasm Staging; Disease; Environment; Evaluation; Excision; Feedback; Foundations; Generations; Goals; Image; Imaging technology; Investments; Ionizing radiation; Laboratories; Light; Link; Malignant Neoplasms; Methods; Molecular; Noise; Operative Surgical Procedures; Optics; Patient Monitoring; Patients; Photons; Phototherapy; Play; Positron-Emission Tomography; Radiation; Radiation Dose Unit; Radionuclide Imaging; Research; Resolution; Role; Safety; Science; Signal Transduction; Source; Staging; Structure; Surgeon; Testing; Therapeutic; Ultrasonography; anticancer research; base; bioimaging; cancer imaging; cancer therapy; cost; detector; fight against; imaging biomarker; imaging modality; improved; in vivo; innovation; instrument; invention; luminescence; molecular imaging; novel strategies; novel therapeutic intervention; optical imaging; photonics; preclinical study; programs; public health relevance; radiotracer; screening; targeted delivery; targeted treatment; theranostics; tool; treatment planning; tumor

 DESCRIPTION (provided by applicant): Imaging is often fundamental to screening, detection, diagnosis and staging of cancer. It also plays significant roles in cancer treatment planning, and in monitoring patients during and after therapy. Imaging also is a vital tool in cancer research, where it is used to improve our understanding of cancer biology and in the longitudinal evaluation of the effects of new therapeutic strategies in preclinical studies. Further development of existing imaging technologies, as well as the invention or discovery of new ones, is critical in the fight against cancer. Improvements in imaging technologies will help us detect disease earlier, stage cancer more accurately, select more appropriate treatments and provide earlier feedback when a treatment is not working. Imaging will become further engrained in interventional cancer therapies, especially in surgery where there is an urgent need for better methods to guide surgeons during resection to avoid functional areas and achieve cancer-free margins wherever possible. We also expect imaging research to enhance cancer imaging through faster and lower cost imaging, and by reducing radiation dose, thus making imaging more widely accessible, and enhancing patient comfort and safety. In the laboratory setting, instruments capable of improved structural, functional and molecular characterization of tumors in appropriate animal models, as well as the development of new imaging biomarkers, often linked with targeted therapies, will be critical in providing the foundation for these advances. Thus further investments in cancer imaging at all levels are likely to yield a high pay off. Molecular imaging with optical contrast or radiotracers provides some of the highest sensitivity in vivo assays available, and offers a rich source of contrast mechanisms. In this proposal we build on our 25-year track record in the field of biomedical imaging and propose to exploit new opportunities for cancer imaging and cancer theranostics that lie at the intersection of photonics and radiation science. We propose initial projects that 1) offer the prospect of high-resolution optical imaging of radionuclides using ultrasound-modulation of Cerenkov luminescence; 2) enable targeted delivery of light to tumors deep inside the body allowing phototherapy to be applied as a systemic treatment for metastatic disease and 3) exploit the instantaneous generation of optical Cerenkov photons in positron emission tomography (PET) detectors with the goal of significantly improving the timing resolution and the signal-to-noise ratio in PET imaging. The approach in this proposal is to create and support a research environment that allows our laboratory to rapidly test and develop new ideas, with a goal of efficiently developing innovative cancer imaging and therapeutic strategies that will either directly (through improved diagnosis, staging or therapy), or indirectly (via contributions o cancer research) benefit cancer patients.

 描述（由申请人提供）：成像通常是癌症筛查、检测、诊断和分期的基础。它还在癌症治疗计划以及治疗期间和治疗后监测患者方面发挥着重要作用。成像也是癌症研究中的重要工具，它可用于提高我们对癌症生物学的理解以及临床前研究中新治疗策略效果的纵向评估。现有成像技术的进一步发展以及新成像技术的发明或发现对于对抗癌症至关重要。成像技术的改进将帮助我们更早地发现疾病，更准确地对癌症进行分期，选择更合适的治疗方法，并在治疗无效时更早地提供反馈。影像学将进一步深入介入癌症治疗，特别是在外科手术中，迫切需要更好的方法来指导外科医生在切除过程中避开功能区域并尽可能实现无癌边缘。我们还期望成像研究能够通过更快、更低成本的成像以及减少辐射剂量来增强癌症成像，从而使成像更容易获得，并提高患者的舒适度和安全性。在实验室环境中，能够在适当的动物模型中改善肿瘤的结构、功能和分子特征的仪器，以及通常与靶向治疗相关的新成像生物标志物的开发，对于为这些进展提供基础至关重要。因此，对各级癌症成像的进一步投资可能会产生高回报。 使用光学对比或放射性示踪剂的分子成像提供了一些现有的最高灵敏度的体内测定，并提供了丰富的对比机制来源。在本提案中，我们以我们在生物医学成像领域 25 年的跟踪记录为基础，提议利用光子学和辐射科学交叉领域的癌症成像和癌症治疗诊断学的新机遇。我们提出的初步项目包括：1）提供利用切伦科夫发光超声调制对放射性核素进行高分辨率光学成像的前景； 2) 能够将光定向输送到体内深处的肿瘤，从而使光疗能够作为转移性疾病的全身治疗方法；3) 利用正电子发射断层扫描 (PET) 探测器中光学切伦科夫光子的瞬时生成，目标是显着提高 PET 成像的时间分辨率和信噪比。 该提案的方法是创建和支持一个研究环境，使我们的实验室能够快速测试和开发新想法，目标是有效开发创新的癌症成像和治疗策略，这些策略将直接（通过改进诊断、分期或治疗）或间接（通过对癌症研究的贡献）使癌症患者受益。

项目成果

First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody.

• DOI: 10.1126/sciadv.adh7968
• 发表时间: 2023-10-13
• 期刊: SCIENCE ADVANCES
• 影响因子: 13.6
• 作者: Omidvari, Negar;Jones, Terry;Price, Pat M.;Ferre, April L.;Lu, Jacqueline;Abdelhafez, Yasser G.;Sen, Fatma;Cohen, Stuart H.;Schmiedehausen, Kristin;Badawi, Ramsey D.;Shacklett, Barbara L.;Wilson, Ian;Cherry, Simon R.
• 通讯作者: Cherry, Simon R.

Ultrafast timing enables reconstruction-free positron emission imaging.

• DOI: 10.1038/s41566-021-00871-2
• 发表时间: 2021-12
• 期刊: NATURE PHOTONICS
• 影响因子: 35
• 作者: Kwon, Sun Il;Ota, Ryosuke;Berg, Eric;Hashimoto, Fumio;Nakajima, Kyohei;Ogawa, Izumi;Tamagawa, Yoichi;Omura, Tomohide;Hasegawa, Tomoyuki;Cherry, Simon R.
• 通讯作者: Cherry, Simon R.

Towards time-of-flight PET with a semiconductor detector.

• DOI: 10.1088/1361-6560/aaaa4e
• 发表时间: 2018-02-16
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Ariño-Estrada G;Mitchell GS;Kwon SI;Du J;Kim H;Cirignano LJ;Shah KS;Cherry SR
• 通讯作者: Cherry SR

Innovations in Instrumentation for Positron Emission Tomography.

• DOI: 10.1053/j.semnuclmed.2018.02.006
• 发表时间: 2018-07
• 期刊: Seminars in nuclear medicine
• 影响因子: 4.9
• 作者: Berg E;Cherry SR
• 通讯作者: Cherry SR

Theoretical investigation of ultrasound-modulated Cerenkov luminescence imaging for higher-resolution imaging in turbid media.

• DOI: 10.1364/ol.43.003509
• 发表时间: 2018-08-01
• 期刊: Optics letters
• 影响因子: 3.6
• 作者: Klein JS;Mitchell GS;Stephens DN;Cherry SR
• 通讯作者: Cherry SR