Acquisition of Analytical Ultracentrifuge at UW

描述（由申请人提供）：寻求华盛顿大学医学院收购现代最先进的分析超敏色谱仪（AUC）。分析超离心是一种强有力的技术，用于表征蛋白质的大小、形状和寡聚状态以及它们与从离子到其他生物大分子的配体的结合。所要求的仪器将服务于NIH支持的六个主要用户，六个次要用户和其他用户的研究项目。自1988年E型离心机退役以来，华盛顿大学的研究人员不得不与另一个非现场小组合作或在收费服务设施中收集AUC数据。这两种模式都没有效率，后者成本极高。已确定的用户组包括医学院内五个基础科学部门的成员和相关的弗雷德哈钦森癌症研究中心的成员。NIH支持的研究将通过所要求的工具得到加强，代表了广泛的人类健康和疾病，包括许多传染病和癌症。

DESCRIPTION (provided by applicant): Acquisition of a modern state-of-the art analytical ultracentrifuge (AUC) by the University Of Washington School Of Medicine is sought. Analytical ultracentrifugation is a powerful technique to characterize the size, shape, and oligomerization state of proteins and their binding of ligands ranging from ions to other biomacromolecules. The requested instrument will serve the NIH-supported research projects of six Major Users, six Minor Users, and other users on a more infrequent basis. Since the decommissioning of a Model E centrifuge in 1988, researchers at UW have had to collect AUC data either in collaboration with another group off-site or at fee-for- service facilities. Neither of these models is efficient and the latter is extremely costly. The identified user group includes members of five basic science departments within the School of Medicine and a member at the associated Fred Hutchinson Cancer Research Center. The NIH-supported research that will be enhanced by the requested instrument represents a wide spectrum of human health and disease, including numerous infectious diseases and cancer.