Acquisition of Analytical Ultracentrifuge at UW

描述(由申请人提供)：寻求由华盛顿大学医学院购买现代最先进的分析性超离心仪(AUC)。分析超速离心法是表征蛋白质的大小、形状和寡聚化状态以及它们与从离子到其他生物大分子的配体结合的一种强有力的技术。所要求的仪器将以更少的频率为NIH支持的六个主要用户、六个次要用户和其他用户的研究项目提供服务。自1988年E型离心机退役以来，威斯康星州大学的研究人员不得不在场外与另一个小组合作或在收费服务设施中收集AUC数据。这两种模式都不是有效的，后一种模式成本极高。确定的用户组包括医学院内五个基础科学系的成员和相关的弗雷德·哈钦森癌症研究中心的一名成员。NIH支持的研究将通过所要求的仪器得到加强，代表了人类健康和疾病的广泛范围，包括许多传染病和癌症。

DESCRIPTION (provided by applicant): Acquisition of a modern state-of-the art analytical ultracentrifuge (AUC) by the University Of Washington School Of Medicine is sought. Analytical ultracentrifugation is a powerful technique to characterize the size, shape, and oligomerization state of proteins and their binding of ligands ranging from ions to other biomacromolecules. The requested instrument will serve the NIH-supported research projects of six Major Users, six Minor Users, and other users on a more infrequent basis. Since the decommissioning of a Model E centrifuge in 1988, researchers at UW have had to collect AUC data either in collaboration with another group off-site or at fee-for- service facilities. Neither of these models is efficient and the latter is extremely costly. The identified user group includes members of five basic science departments within the School of Medicine and a member at the associated Fred Hutchinson Cancer Research Center. The NIH-supported research that will be enhanced by the requested instrument represents a wide spectrum of human health and disease, including numerous infectious diseases and cancer.