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Age Related Bone Loss Assessed by Ultrasound Tomography: Bone Quality Beyond BMD

通过超声断层扫描评估与年龄相关的骨质流失：骨质量超越 BMD

基本信息

批准号：
8043597
负责人：
Luis Cardoso
金额：
$ 14.71万
依托单位：
CITY COLLEGE OF NEW YORK
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-02-01 至 2013-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8043597
关键词：
Accounting Achievement Acoustics Address Age Age-Related Bone Loss Algorithms Anisotropy Basic Science Behavior Biomechanics Biomedical Engineering Bone Density Bone Tissue Boxing Cadaver Characteristics Cities Clinical Detection Development Devices Engineering Fostering Foundations Fracture Fracture Healing Funding Funding Agency Generations Gold Human In Vitro Intellectual Property Laboratories Liquid substance Marrow Measurement Measures Mechanics Mesenchymal Stem Cells Methods Minerals Minority Modeling Monitor Musculoskeletal Osteoporosis Outcome Pathology Peer Review Phase Play Porosity Property Publications Radial Radiation Relative (related person)Reporting Research Research Project Grants Research Training Risk Roentgen Rays Role Sampling Sensitivity and Specificity Solid Speed Structure Students System Testing Theoretical model Thick Tissues Ultrasonic wave Ultrasonography United States National Aeronautics and Space Administration United States National Institutes of Health Vertebral column Wrist attenuation base bisphosphonate bone bone geometry bone loss bone mass bone quality bone strength college comparative efficacy computerized data processing density graduate student improved meetings neglect novel diagnostics osteosarcoma sound spine bone structure substantia spongiosa tomography tool

项目摘要

DESCRIPTION (provided by applicant): The gold standard to assess bone loss with age is the Bone Mineral Density (BMD), because this measurement highly correlates to bone mass. However, the BMD cannot fully explain the decrease in bone strength and the associated risk of fracture, indicating that other factors beside bone mass play an important role. Ultrasound is also used to evaluate bone properties by measuring the velocity and the attenuation of longitudinal waves. Unfortunately, most of current clinical ultrasound devices aim to determine bone mass density, as DXA does, without taking advantage of the fact that ultrasound is sensitive to geometry, trabecular orientation and tissue composition. Recent in vitro studies have provided evidence of the propagation of two different longitudinal wave modes in cancellous bone, as predicted by the poroelastic approach of wave propagation originally developed by Maurice A. Biot. However, most current ultrasound approaches consider only one wave to propagate in cancellous bone, and the wave velocity/attenuation is usually analyzed as a function of the bone mass density only. It is important to note that reported velocities in highly osteoporotic bone (for instance 90% fluid and 10% solid) never shows values below 1450m/s, which is the speed of sound in marrow. This observation suggests that in highly porous samples, the fraction of the media being characterized by the measured wave is the fluid one, as opposed to the solid trabecular structure. The relevance of the ultrasound black box approach to distinguish the changes in the trabecular microstructure is therefore challenged. In this proposal, we intent to combine Biot's poroelastic approach with a tomography based (multidirectional) assessment of acoustic properties in bone. The major advantage of the poroelastic approach is that it predicts the existence of two waves and characterizes the relative contribution of the solid and fluid bone fractions on ultrasound wave velocity/attenuation. The role of the anisotropic solid structure and fluid in the behavior of the fast and slow wave velocities is examined. From the acoustic properties, the elastic properties of bone are derived and then compared to mechanical testing measurements. This approach has the potential to better characterize changes due to bone loss with age and to provide a first step for defining a criterion for bone loss beyond bone mineral density. Project Narrative and Relevance: The proposed study has the potential to produce a highly medically significant result. Achievement of the proposed aims would enable further research possibly leading to the development of new diagnostic devices capable of greater sensitivity and specificity for the detection and grading of osteoporosis risk.

描述（由申请人提供）：评估随年龄增长骨质流失的黄金标准是骨矿物质密度（BMD），因为该测量值与骨量高度相关。然而，骨密度不能完全解释骨强度的下降和相关的骨折风险，这表明骨量以外的其他因素也发挥着重要作用。超声波还用于通过测量纵波的速度和衰减来评估骨骼特性。不幸的是，大多数当前临床超声设备的目的是确定骨量密度，如 DXA 所做的那样，而没有利用超声对几何形状、小梁方向和组织成分敏感的事实。最近的体外研究提供了松质骨中两种不同纵波模式传播的证据，正如莫里斯·A·比奥最初开发的波传播的多孔弹性方法所预测的那样。然而，大多数当前超声方法仅考虑一种波在松质骨中传播，并且波速/衰减通常仅作为骨质量密度的函数进行分析。值得注意的是，报告的高度骨质疏松骨骼（例如 90% 液体和 10% 固体）中的速度从未显示低于 1450m/s（即骨髓中的声速）的值。这一观察结果表明，在高度多孔的样品中，由测量波表征的介质部分是流体介质，而不是固体小梁结构。因此，超声黑盒方法区分小梁微观结构变化的相关性受到了挑战。在本提案中，我们打算将 Biot 的多孔弹性方法与基于断层扫描的（多向）骨骼声学特性评估相结合。多孔弹性方法的主要优点是它可以预测两种波的存在，并表征固体和液体骨部分对超声波速度/衰减的相对贡献。研究了各向异性固体结构和流体在快波和慢波速度行为中的作用。根据声学特性，得出骨骼的弹性特性，然后与机械测试测量结果进行比较。这种方法有可能更好地表征因年龄增长引起的骨质流失的变化，并为定义骨矿物质密度以外的骨质流失标准提供第一步。项目叙述和相关性：拟议的研究有可能产生具有高度医学意义的结果。实现所提出的目标将使进一步的研究成为可能，从而开发出能够对骨质疏松症风险的检测和分级具有更高敏感性和特异性的新诊断设备。

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Blood and interstitial flow in the hierarchical pore space architecture of bone tissue.

DOI：
10.1016/j.jbiomech.2014.12.013
发表时间：
2015-03-18
期刊：
JOURNAL OF BIOMECHANICS
影响因子：
2.4
作者：
Cowin, Stephen C.;Cardoso, Luis
通讯作者：
Cardoso, Luis

Mixture theory-based poroelasticity as a model of interstitial tissue growth.

基于混合理论的孔隙弹性作为间质组织生长的模型。

DOI：
10.1016/j.mechmat.2011.07.005
发表时间：
2012
期刊：
Mechanics of materials : an international journal
影响因子：
0
作者：
Cowin,StephenC;Cardoso,Luis
通讯作者：
Cardoso,Luis

Effect of tissue properties, shape and orientation of microcalcifications on vulnerable cap stability using different hyperelastic constitutive models.

DOI：
10.1016/j.jbiomech.2014.01.010
发表时间：
2014-03-03
期刊：
JOURNAL OF BIOMECHANICS
影响因子：
2.4
作者：
Cardoso, Luis;Kelly-Arnold, Adreanne;Maldonado, Natalia;Laudier, Damien;Weinbaum, Sheldon
通讯作者：
Weinbaum, Sheldon

Experimental determination of the permeability in the lacunar-canalicular porosity of bone.