High-risk HPV infections in 18- 24-year-old women who date on-line

描述（由研究者提供）：HPV患病率在20岁出头的女性中最高，并随着年龄的增长而降低。虽然青少年和年轻女性感染HPV的许多危险因素都是明确的（包括新的性伴侣的报告），但尚不清楚通过网络约会或社交网站寻找性伴侣是否与HPV感染风险增加有关。在我们正在进行的25-65岁在线约会女性高危（HR HPV）感染的纵向研究中，最近在网上结识的伴侣（相对于通过其他方式）与HR HPV感染的风险增加有关，但对年轻异性恋女性的研究一直模棱两可。了解人群特定的HPV感染风险因素对于制定准确的公共卫生信息和HPV预防策略至关重要。为了检查18-24岁在线约会者中HR HPV感染的危险因素，我们建议对过去一年中使用在线约会网站的200名美国女性进行纵向研究。女性将通过互联网招募。在一年的时间里，女性将被要求邮寄四套自我收集的阴道样本用于HPV DNA测试（在0、4、8和12个月），并完成关于她们的健康和性行为的问卷调查（在0、4、8和12个月）以及对自我收集阴道样本的态度的问卷调查（在研究参与结束时）。阴道样本将使用基于聚合酶链反应（pcr）的测定法检测特定类型的HPV DNA。该研究方案将与我们正在进行的25-65岁女性HR HPV感染的研究相同，因此也将允许我们直接比较25-65岁女性（其HPV感染率高于文献报道）和18-24岁女性HR HPV感染的患病率和发病率。该研究的具体目标是：1)确定18-24岁在线约会女性感染人乳头瘤病毒的危险因素；2)比较18-24岁女性HR HPV的患病率和发病率与先前招募并遵循相同方案的老年女性（25-44岁和45-65岁）HR HPV的患病率和发病率；3)评估研究参与者自采阴道样本的经验，以及对自采阴道样本用于HPV和其他性传播感染检测的诊断试剂盒的普遍兴趣。

DESCRIPTION (provided by investigator): HPV prevalence is highest among women in their early twenties and decreases with age. While many risk factors for HPV infections in adolescent and young women are well-defined (including reports of new sex partners), it is unclear whether seeking sex partners via Internet dating or social networking websites is associated with increased risk of HPV infection. In our ongoing longitudinal study of high-risk (HR HPV) infections in 25-65 year old women who date online, having met recent partners online (versus via other means) was associated with an increased risk of HR HPV infection, but studies of younger heterosexual women have been equivocal. Understanding population-specific risk factors for HPV infection are critical to developing accurate public health messages and HPV prevention strategies. To examine risk factors for HR HPV infections in 18-24 year old online daters, we propose a longitudinal study of 200 women in the United States who have used online dating websites in the past year. Women will be recruited through the Internet. For one year, women will be asked to mail in four sets of self-collected vaginal specimens for HPV DNA testing (at 0, 4, 8, and 12 months), and to complete questionnaires on their health and sexual behavior (at 0, 4, 8, and 12 months) and attitudes towards self-collecting vaginal samples (at the end of study participation). Vaginal samples will be tested for type-specific HPV DNA using a PCR-based assay. The study protocol will be identical to our ongoing study of HR HPV infections in 25-65 year old women, and will thus also allow us to directly compare prevalence and incidence of HR HPV infections in 25-65 year old women (whose rates of HPV infection are higher than those reported in the literature) to 18-24 year old women. The specific aims of are to 1) identify risk factors for HR HPV infections in 18-24 year old women who date online; 2) compare the prevalence and incidence of HR HPV in 18-24 year old women to the prevalence and incidence of HR HPV in older (25-44 year old and 45-65 year old) women previously recruited and followed with an identical protocol; and 3) evaluate study participants' experiences with self-collecting vaginal samples and general interest in diagnostic kits for self-collecting vaginal samples for HPV and other STI testing. PUBLIC HEALTH RELEVANCE: Relevance: Findings from this study of HR HPV in 18-24 year old women who date online will inform population-specific public health messages and HPV prevention strategies.