HPV Infections in Older Women

老年女性的 HPV 感染

• 批准号: 8115468
• 负责人: RACHEL L. WINER
• 金额: $ 5万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8115468
• 关键词: Address; Age; Age-Years; Area; Attitude; Award; Cervical; Cervical Cancer Screening; Cervical dysplasia; Characteristics; DNA; Data Analyses; Data Collection; Detection; Development; Divorce; Doctor of Philosophy; Enrollment; Epidemiologist; Frequencies; Goals; Guidelines; Health; Hormones; Human Papillomavirus; Human papillomavirus 16; Incidence; Infection; Internet; Longitudinal Studies; Mails; Malignant neoplasm of cervix uteri; Manuscripts; Marriage; Menopausal Status; Mentored Research Scientist Development Award; Mentorship; Methods; National Institute of Allergy and Infectious Disease; Natural History; Neoplasms; Oncogenic; Participant; Pilot Projects; Population; Population Study; Preparation; Prevalence; Prevention; Prevention strategy; Principal Investigator; Protocols documentation; Publications; Questionnaires; Recording of previous events; Recruitment Activity; Relative (related person); Reporting; Research; Risk; Sampling; Sex Behavior; Sexual Partners; Smoke; Smoking; Specimen; Subgroup; Testing; United States; Universities; Vaccination; Vaccines; Vagina; Washington; Woman; age group; aged; base; behavioral health; career; cohort; condoms; experience; high risk; human old age (65+); older women; parity; prophylactic

DESCRIPTION (provided by applicant): Rachel Winer, PhD is an epidemiologist whose goal is to establish an independent research career in the area of HPV prevention in less-studied populations. Whether older women who acquire new sex partners are susceptible to new, persistent HPV infections is largely unknown. With divorce, dating, and second marriage common among women over 25 years of age, risks of new oncogenic HPV infection and neoplasia might be greater now than in previous decades. Dr. Winer is conducting a pilot study of oncogenic HPV infections in 25 to 65 year old women. Under the mentorship of Dr. Koutsky at the University of Washington, the proposed five-year K01 award will allow Dr. Winer to conduct a longitudinal study of HPV infections in older women. During the first year and a half, Dr. Winer will complete the pilot study, develop study materials and protocols for the longitudinal study, and complete additional coursework. The longitudinal study will be conducted during the next two years. 300 women (150 women aged 25 to 44 and 150 women aged 45 to 65) who report having used online dating websites in the past year will be recruited through the Internet. For one year, women will be asked to mail in four sets of self-collected vaginal specimens for HPV DNA testing (at 0, 4, 8, and 12 months), and to complete questionnaires on their health and sexual behavior (at 0, 4, 8, and 12 months) and attitudes towards self-collecting vaginal samples (at the end of study participation). Samples will be analyzed for HPV DNA using PCR-based methods. The specific aims of the longitudinal study are to 1) identify behavioral and health predictors of type-specific oncogenic HPV DNA infections in 25 to 44 year old women and in 45 to 65 year old women; 2) identify predictors of repeatedly-detected oncogenic HPV infections; and 3) evaluate study participants' experiences with self-collecting vaginal specimens and attitudes towards HPV vaccination and cervical cancer screening. During the last year and a half, Dr. Winer will prepare manuscripts for publication and complete a competitive R01 application to further investigate the natural history of HPV infections in older women. This information is important for developing HPV prevention strategies, including vaccine implementation and cervical cancer screening guidelines in populations of older women.

描述（由申请人提供）：Rachel Winer 博士是一位流行病学家，其目标是在研究较少的人群中建立 HPV 预防领域的独立研究生涯。获得新性伴侣的老年女性是否容易受到新的、持续的 HPV 感染尚不清楚。由于离婚、约会和二婚在 25 岁以上女性中很常见，新的致癌 HPV 感染和肿瘤形成的风险现在可能比过去几十年更大。 Winer 博士正在对 25 至 65 岁女性的致癌 HPV 感染进行初步研究。在华盛顿大学 Koutsky 博士的指导下，拟议的为期五年的 K01 奖将使 Winer 博士能够对老年女性的 HPV 感染进行纵向研究。在第一年半的时间里，Winer 博士将完成试点研究，为纵向研究开发学习材料和方案，并完成额外的课程。纵向研究将在未来两年内进行。将通过互联网招募 300 名自称在过去一年使用过在线约会网站的女性（150 名 25 至 44 岁女性和 150 名 45 至 65 岁女性）。在一年内，女性将被要求邮寄四套自行采集的阴道样本进行 HPV DNA 检测（在 0、4、8 和 12 个月时），并完成有关其健康和性行为（在 0、4、8 和 12 个月时）以及对自行采集阴道样本的态度（在研究参与结束时）的调查问卷。将使用基于 PCR 的方法对样本进行 HPV DNA 分析。纵向研究的具体目的是 1) 确定 25 至 44 岁女性和 45 至 65 岁女性特定类型致癌 HPV DNA 感染的行为和健康预测因子； 2) 确定重复检测到的致癌 HPV 感染的预测因子； 3) 评估研究参与者自行采集阴道标本的经验以及对 HPV 疫苗接种和宫颈癌筛查的态度。在过去一年半的时间里，Winer 博士将准备出版手稿并完成竞争性 R01 申请，以进一步研究老年女性 HPV 感染的自然史。这些信息对于制定 HPV 预防策略非常重要，包括老年妇女群体的疫苗实施和宫颈癌筛查指南。