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Dietary supplement use, physical activity, body mass index, and pancreatic cancer

膳食补充剂的使用、体力活动、体重指数和胰腺癌

基本信息

批准号：
8055989
负责人：
Ka Kahe
金额：
$ 7.18万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-01 至 2012-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8055989
关键词：
18 year old Address Adult Affect Age American Anti-Inflammatory Agents Anti-inflammatory Antioxidants Area Ascorbic Acid Behavioral Benefits and Risks Beta Carotene Body Weight Body mass index Botanicals Cancer Etiology Cancer Prognosis Carotene Catchment Area Cessation of life Cohort Studies Country County Data Data Analyses Development Diagnosis Diet Dietary Component Disease Environmental Exposure Epidemiologic Studies Folate Funding Ginkgo biloba Goals Health High Prevalence Incidence Individual Inflammation Intake Investigation Iron Knowledge Life Life Style Link Malignant Neoplasms Malignant neoplasm of pancreas Measures Methods Minerals Multivitamin National Cancer Institute Non-Insulin-Dependent Diabetes Mellitus Nutrient Obesity Omega-3 Fatty Acids Out-Migrations Oxidative Stress Participant Pharmaceutical Preparations Physical activity Pilot Projects Prevention Property Public Health Questionnaires Recording of previous events Recruitment Activity Registries Relative (related person)Resources Risk Risk Factors Role Selenium Staging Survival Rate System Time United States Variant Vitamin E Vitamins Washington Woman aged anticancer research base cancer risk case control chronic pancreatitis cigarette smoking cohort conventional therapy dietary supplements dosage energy balance epidemiologic data follow-up interest lycopene member men modifiable risk neoplasm registry outcome forecast prevent protective effect

项目摘要

DESCRIPTION (provided by applicant): Pancreatic cancer is the fourth most common cause of cancer deaths in the United States (U.S.), has a very poor prognosis, and is generally unresponsive to conventional therapies. Therefore, it is critical to identify modifiable factors that can be used in prevention efforts to reduce risk for developing this disease. Diet, physical activity, and obesity have been postulated to potentially influence pancreatic cancer risk, but results are inconsistent. Also, millions of Americans use dietary (vitamin, mineral, and herbal) supplements to prevent cancer and other diseases, but with few exceptions, there is sparse evidence for either their benefits or risks. Specific Aims The goal of this study is to examine associations of various dietary supplements with pancreatic cancer incidence, using previously collected data from a large cohort study with a high proportion of supplement users. The primary specific aims are to investigate associations of supplemental intakes of nutrients with anti-inflammatory (vitamin E, selenium, and omega-3 fatty acids) and antioxidant properties (vitamin C, vitamin E, beta-carotene, lycopene, and selenium) over the 10-year period ending at baseline with the incidence of pancreatic cancer. Secondary aims are to examine associations of intakes of specific, less common vitamin, mineral, botanical, and other supplements (e.g., folate, iron, gingko biloba) and non- steroidal anti-inflammatory drugs (NSAIDs); as well as physical activity and body mass index levels at baseline and ages 18, 30, and 45 years with pancreatic cancer incidence. Methods Between 2000-2002, 77,738 men and women, aged 50-76 from western Washington State completed a baseline questionnaire that captured detailed information on use of 38 supplements over the previous 10 years, diet, physical activity (using a validated questionnaire), anthropometrics, health history, and cancer risk factors. Supplement users were targeted in recruitment; therefore, supplement use by cohort members is both high and of long duration: 79% were ever users of a supplement, and 66% used multivitamins,46% used individual vitamin C, and 47% used individual vitamin E, typically for 5-8 of the previous 10years. The cohort is being followed for pancreatic cancers by linkage to the western Washington SEER cancer registry, deaths by linkage to the Washington State death file, and out-migration from the SEER catchment area by linkage to the National Change of Address system. This proposal seeks funds to conduct analyses addressing the specific aims. We expect to identify 215 pancreatic cancer cases after a mean follow-up of 8.3 years. The primary exposure would be average intake per day over the previous 10 years of the nutrient of interest (single supplements plus multivitamins), and all analyses will be adjusted for diet and other potential confounders and effect modifiers. Significance The results of this study will be one of the first to examine associations of dietary supplement use, as well as physical activity and obesity, with risk for pancreatic cancer, a disease with a high fatality rate and few known modifiable risk factors. We would use data from the only cohort study specifically focused on the etiologic relationships of dietary supplements with cancer risk which carefully measured supplement use and confounding factors. Importantly, given the high prevalence of dietary supplement use in the U.S., our findings will have important public health implications regardless of whether we find protective effects, increased risks, or no effects of supplements on pancreatic cancer risk.

描述（由申请人提供）：胰腺癌是美国癌症死亡的第四大常见原因，预后非常差，并且通常对常规治疗无反应。因此，确定可用于预防工作的可改变因素以降低发生这种疾病的风险至关重要。饮食、体力活动和肥胖被认为可能影响胰腺癌的风险，但结果并不一致。此外，数百万美国人使用膳食（维生素，矿物质和草药）补充剂来预防癌症和其他疾病，但除了少数例外，很少有证据表明它们的益处或风险。具体目的本研究的目的是研究各种膳食补充剂与胰腺癌发病率的关系，使用之前从一项大型队列研究中收集的数据，其中补充剂使用者比例较高。主要的具体目的是调查在基线结束的10年期间，营养素补充摄入与抗炎（维生素E、硒和omega-3脂肪酸）和抗氧化特性（维生素C、维生素E、β-胡萝卜素、番茄红素和硒）与胰腺癌发病率的关系。次要目的是检查特定的、不太常见的维生素、矿物质、植物和其他补充剂（例如，叶酸、铁、银杏叶）和非甾体抗炎药（NSAID）;以及基线和年龄18、30和45岁时的身体活动和体重指数水平与胰腺癌发病率。方法2000-2002年，来自西部华盛顿州的77,738名年龄在50-76岁的男性和女性完成了一份基线问卷，该问卷收集了过去10年中使用38种补充剂的详细信息，饮食，体力活动（使用经过验证的问卷），人体测量学，健康史和癌症风险因素。补充剂使用者是招募的目标;因此，队列成员的补充剂使用率高且持续时间长：79%曾经使用过补充剂，66%使用多种维生素，46%使用单一维生素C，47%使用单一维生素E，通常在过去10年中使用5-8年。通过与西部华盛顿SEER癌症登记处的联系，通过与华盛顿州死亡档案的联系，以及通过与国家地址变更系统的联系，对该队列进行胰腺癌随访。这项提案寻求资金，以便针对具体目标进行分析。我们预计在平均随访8.3年后将确定215例胰腺癌病例。主要暴露量是过去10年中感兴趣的营养素（单一补充剂加多种维生素）的平均每日摄入量，所有分析都将针对饮食和其他潜在混杂因素和效应调节剂进行调整。这项研究的结果将是第一个检查膳食补充剂使用，以及体育活动和肥胖与胰腺癌风险之间关系的研究之一，胰腺癌是一种死亡率高，已知可改变的风险因素很少的疾病。我们将使用唯一一项专门关注膳食补充剂与癌症风险病因关系的队列研究的数据，该研究仔细测量了补充剂的使用和混杂因素。重要的是，鉴于美国膳食补充剂的使用率很高，无论我们发现补充剂对胰腺癌风险是否有保护作用、增加风险或没有影响，我们的发现都将对公共卫生产生重要影响。