Trace mineral levels, the trajectory of cognitive decline and telomere attrition

微量矿物质水平、认知能力下降和端粒磨损的轨迹

• 批准号: 9332844
• 负责人: Ka Kahe
• 金额: $ 105.3万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-15 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9332844
• 关键词: Adult; Affect; African American; Aging; American; Ancillary Study; Anti-Inflammatory Agents; Anti-inflammatory; Antioxidants; Arsenic; Biological Markers; Blood; Cadmium; Caucasians; Cells; Chromosomes; Cognition; Cognitive; Data; Diet; Disease; Elements; Foundations; Funding; Future; General Population; Health; Heavy Metals; Heritability; Homeostasis; Human; Impaired cognition; Impairment; Individual; Intervention; Knowledge; Learning; Length; Leukocytes; Link; Literature; Magnesium; Measurement; Measures; Mercury; Metal exposure; Micronutrients; Minerals; Nutritional; Participant; Persons; Physiological Processes; Play; Population; Prevention; Prevention strategy; Public Health; Race; Research; Risk; Role; Sampling; Selenium; Serum; Stroke; Trace Elements; United States National Institutes of Health; Urine; Visit; age effect; aged; base; cofactor; cognitive function; cohort; epidemiology study; follow-up; geographic difference; healthy aging; high risk; immune function; improved; interest; lifestyle factors; mortality; population based; pre-clinical; prevent; racial difference; remediation; repository; sex; study population; telomere

Studies indicate that a satisfactory content of some micronutrients within the cells maintains several immune functions, anti-inflammatory and anti-oxidant activities, which together may play a pivotal role in reducing the effects of aging. In contrast, although the underlying mechanisms are unclear, studies have linked some heavy metal exposure to cognitive decline, which is clearly associated with aging. Despite this, there remains a critical gap in the literature on how trace minerals, both nutritious elements and heavy metals, affect cognitive health. In particular, data directly relating trace mineral levels to cognitive decline are lacking. In addition, leukocyte telomere length (TL) has been consistently shown to have a direct relation with mortality and aging- related diseases in epidemiological studies, and is thus considered to be a biomarker of aging. TL has also been linked to cognitive function in different populations. Although TL is heritable, it can be modified by a host of environmental variables. Thus, identifying modifiable factors that may slow or prevent TL attrition would certainly have a major public health impact, as possible interventions are likely to be most effective during the early stages of preclinical disease. The overall objective of this project is to examine the longitudinal associations between trace mineral levels and cognitive decline and TL. Specifically, we will examine the trace mineral concentrations measured in urine or serum in relation to the trajectory of cognitive decline, as well as TL, and telomere attrition in a sub-cohort (n=2,391) of participants randomly selected from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study, an ongoing US national population-based, general population cohort of 30,239 African American and Caucasian adults, aged 45 and older at baseline (2003-2007). The proposed study will help to identify at-risk Americans for cognitive decline and/or the consequences of aging. For nutritious minerals, information generated from this study will be useful for future interventions to maintain a homeostasis of micronutrients in relation to healthy aging; and for the toxic ones at low-to-moderate exposure level, knowledge gained will serve as a scientific foundation for remediation and prevention strategies to improve cognitive health or slow down the consequences of aging.

研究表明，细胞内某些微量营养素的含量令人满意，可维持几种免疫力。 功能、抗炎和抗氧化活性，这些共同可能在减少 老化的影响。相比之下，尽管潜在的机制尚不清楚，但研究已经将一些重大的 接触金属会导致认知能力下降，这显然与衰老有关。尽管如此，仍然有一个 关于微量矿物质--营养元素和重金属--如何影响认知的文献中的关键空白 健康。特别是，缺乏将微量矿物质水平与认知能力下降直接联系起来的数据。此外, 白细胞端粒长度(TL)一直被证明与死亡率和衰老有直接关系。 流行病学研究中的相关疾病，因此被认为是衰老的生物标记物。TL也有 与不同人群的认知功能有关。虽然TL是可遗传的，但它可以由主机修改 环境变量的影响。因此，确定可以减缓或防止TL损耗的可修改因素将 肯定会对公共卫生产生重大影响，因为可能的干预措施很可能在 临床前疾病的早期阶段。该项目的总体目标是检查纵向 微量矿物质水平与认知功能减退和TL的关系。具体地说，我们将检查跟踪 尿液或血清中测定的矿物质浓度与认知能力下降的轨迹以及 TL和端粒磨损在随机从以下原因中选择的参与者的子队列(n=2,391)中 中风的地理和种族差异研究，这是一项正在进行的以美国全国人口为基础的研究， 30,239名非洲裔美国人和高加索成年人的总人口队列，基线年龄为45岁及以上 (2003-2007)。这项拟议的研究将有助于确定高危美国人的认知下降和/或 老龄化的后果。对于营养矿物质，这项研究产生的信息将对未来有用 与健康老龄化有关的维持微量营养素动态平衡的干预措施；以及 低至中等暴露水平，所获得的知识将作为补救和 改善认知健康或减缓衰老后果的预防策略。