Serum fatty acids and ischemic stroke in women

女性血清脂肪酸与缺血性中风

• 批准号: 7470251
• 负责人: Ka Kahe
• 金额: $ 26.33万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7470251
• 关键词: Acids; Animals; Arachidonic Acids; Arteries; Arteriosclerosis; Atherosclerosis; Biological; Biological Markers; Blood Pressure; Blood specimen; Clinical; Coronary heart disease; Data; Databases; Development; Dietary Fats; Eicosapentaenoic Acid; Epidemiologic Studies; Etiology; Fatty Acids; Fatty acid glycerol esters; Funding; Goals; Infarction; Intake; Ischemic Stroke; Knowledge; Life Style; Linoleic Acids; Linolenic Acids; Lipoproteins; Measurement; Myristic Acids; Nested Case-Control Study; Nutrient; Observational Study; Omega-3 Fatty Acids; Omega-6 Fatty Acids; Palmitic Acids; Pathogenesis; Patient Self-Report; Pattern; Play; Postmenopause; Public Health; Rate; Risk; Risk Factors; Role; Saturated Fatty Acids; Serum; Stroke; Testing; Trans Fatty Acids; Vascular Diseases; Woman; Women' s Health; blood lipid; case control; cerebral artery; disorder risk; elaidic acid; prospective; tool

DESCRIPTION (provided by applicant): While coronary heart disease (CHD) and ischemic stroke share some major risk factors, limited epidemiological data on dietary fats and vascular disease risk indicate that fatty acids have different associations with ischemic stroke than with CHD. The established associations between types of fat and CHD do not appear to apply to ischemic stroke. One explanatory hypothesis for the paradoxical observations is that arteriosclerosis in different types of cerebral arteries has different causal patterns. Particularly, atherosclerosis may only be involved in large artery infarction, and other risk factors such as blood pressure may play more important role in stroke development However, data on the associations of fatty acids and ischemic stroke and its subtypes including lacunar (small artery), atherosclerotic (large artery) and cardioembolic infarction are lacking. The general goal of this study is to examine the associations between serum fatty acids and risk of ischemic stroke and its subtypes among postmenopausal women. A prospective nested case-control study of 971 ischemic stroke cases and 971 matched controls in the Women's Health Initiative (WHI) Observational Study is proposed to achieve the objectives. Two major endeavors are planned for the proposed project: 1) assess serum fatty acids composition with previously collected and stored blood specimens; and 2) perform the statistical analyses, which undertake the specific aims and hypothesis. The proposed study will fill the gap in knowledge regarding associations of fatty acids and subtypes of ischemic stroke. Findings from this project will potentially help identify people at high risk of ischemic stroke as well as clarify possible differences between fatty acids and risk of ischemic stroke versus risk of CHD. The proposed study is to examine the associations between serum fatty acids and risk of ischemic stroke and its subtypes among postmenopausal women who are at increased risk of stroke. It is a timely and economical approach for investigating stroke risk in postmenopausal women. The data generated from this study should provide new information on the etiology of ischemic stroke and data for new explorations of dietary causes. PUBLIC HEALTH RELEVANCE: The proposed study is to examine the associations between serum fatty acids and risk of ischemic stroke and its subtypes among postmenopausal women who are at increased risk of stroke. It is a timely and economical approach for investigating stroke risk in postmenopausal women. The data generated from this study should provide new information on the etiology of ischemic stroke and data for new explorations of dietary causes.

描述（由申请人提供）：虽然冠心病（CHD）和缺血性卒中有一些共同的主要危险因素，但有限的膳食脂肪和血管疾病风险的流行病学数据表明，脂肪酸与缺血性卒中的关系不同于与冠心病的关系。已确立的脂肪类型与冠心病之间的联系似乎不适用于缺血性中风。对这些矛盾的观察结果的一个解释假设是，不同类型脑动脉的动脉硬化具有不同的因果模式。特别是动脉粥样硬化可能只与大动脉梗死有关，血压等其他危险因素可能在卒中发展中发挥更重要的作用。然而，脂肪酸与缺血性卒中及其亚型(包括腔隙性（小动脉）、动脉粥样硬化性（大动脉）和心栓性梗死之间的关联数据缺乏。本研究的总体目标是研究血清脂肪酸与绝经后妇女缺血性卒中及其亚型风险之间的关系。在妇女健康倡议（WHI）观察性研究中，提出了一项针对971例缺血性卒中病例和971例匹配对照的前瞻性巢式病例对照研究。拟建项目计划开展两项主要工作：1)利用先前收集和储存的血液标本评估血清脂肪酸组成；2)进行统计分析，承担具体的目标和假设。提出的研究将填补关于脂肪酸和缺血性脑卒中亚型之间关系的知识空白。这个项目的发现将有可能帮助识别缺血性中风高风险人群，并阐明脂肪酸与缺血性中风风险和冠心病风险之间的可能差异。该研究旨在研究绝经后卒中风险增加的妇女血清脂肪酸与缺血性卒中及其亚型风险之间的关系。这是一种及时和经济的方法来调查绝经后妇女卒中风险。本研究的数据将为缺血性脑卒中的病因学提供新的信息，并为饮食原因的新探索提供数据。公共卫生相关性：拟议的研究旨在检查绝经后卒中风险增加的妇女血清脂肪酸与缺血性卒中及其亚型风险之间的关系。这是一种及时和经济的方法来调查绝经后妇女卒中风险。本研究的数据将为缺血性脑卒中的病因学提供新的信息，并为饮食原因的新探索提供数据。