Smart Bio-Imaging

智能生物成像

• 批准号: ST/F003722/1
• 负责人: Gordon Love
• 金额: $ 13.41万
• 依托单位: Durham University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ST%2FF003722%2F1
• 关键词: Smart; Bio; Imaging

Since the first application of the microscopy by Robert Hooke (Micrographia, published in 1665), the biological and medical sciences have been entirely dependent upon this technology and all its subsequent developments for discovery and health/wealth applications. The desire to observe living cells and their processes is a continual driver for further technological enhancements of current microscopes as scientists seek to observe and understand the molecular processes and their dynamics in living organisms. This project has two major goals - both of which seek to enhance the performanc of microscopes 1. To produce a 'smart camera' which can track the position of a multitude of rapidly moving particles 2. To produce a 'smart camera' which can track the position of very low contrast objects which will reduce the need for fluorescent labelling of cells which can severely damage them. The work will be based on technology which has been developed for astronomical adaptive optics. Here it is critical to to process data about the atmosphere in real time and feed it back to a deformable mirror in order to correct for distortions caused by the passage of light through the atmosphere. atmosphere.

自从罗伯特·胡克(1665年出版)首次应用显微镜以来，生物和医学科学一直完全依赖于这项技术及其随后的所有发展，以实现发现和健康/财富的应用。随着科学家试图观察和了解活生物中的分子过程及其动力学，观察活细胞及其过程的愿望是当前显微镜进一步技术改进的持续驱动力。该项目有两个主要目标--这两个目标都是为了提高显微镜的性能1.生产一种可以跟踪大量快速运动粒子位置的“智能相机”2.生产一种可以跟踪极低对比度物体位置的“智能相机”，这将减少对细胞进行荧光标记的需要，因为这可能会对细胞造成严重损害。这项工作将基于为天文自适应光学开发的技术。在这里，关键是要实时处理有关大气的数据，并将其反馈到可变形镜，以便校正光线通过大气造成的扭曲。大气层。