Developmental Pathways to Suicide Attempt

自杀未遂的发展途径

基本信息

  • 批准号:
    8048435
  • 负责人:
  • 金额:
    $ 26.64万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-01-01 至 2012-12-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): This exploratory study will examine if there are unique pathways to suicide attempt using 13 waves of prospective longitudinal data on two ongoing epidemiologically sampled cohorts of 2953 young adults (300 with a prior suicide attempt) originally recruited upon entry to first grade in 28 inner city Public Schools in Baltimore, Maryland. This project will assess the influence of individual psychiatric, familial (parenting, family history), environmental (exposure to violence, sexual/physical abuse), social, and high risk behaviors (sexual, drug use) during the course of development on distinct pathways to suicide attempt. Research has shown that it is very difficult to predict suicide deaths and suicide attempt, perhaps because there are multiple pathways or subtypes. The identification of subtypes is highly significant because appropriate intervention approaches for subtypes may differ. It is also possible that the SA subtypes could represent more homogenous genetic groups yielding greater ability to detect genetic variation in vulnerability for SA. Studies have identified risk and protective factors but few have identified multiple factors prospectively through the course of development to identify processes or mechanisms. The majority of participants with SA in our community sample (~60%) have never met DSM-IV criteria for a major depressive episode. There is a growing literature on the importance of trait aggression/impulsivity as a strong indicator of suicide risk with a possible biological basis. It is unclear if there is a distinct subgroup defined by trait aggression with increased liability of SA. We will study multiple domains of childhood, adolescent and young adult experiences as reported by the participants, peers, parents, teachers, and public records (arrest records). The project will assess the effect of specific genetic markers of risk for suicide attempt (i.e., SLC6A4, TPH1, BDNF, FKBP5) overall and in subgroups, based upon the developmental pathways or trajectories identified. The results of this study will advance our current understanding of the processes and mechanisms associated with suicide attempts among ethnically diverse, urban community populations. PUBLIC HEALTH RELEVANCE: This R21 project entitled "Developmental Pathways to Suicide Attempt" aims to identify distinct pathways or trajectories to suicide attempt in 2953 young adults (300 suicide attempters) initially recruited upon entry to first grade in Baltimore City Public Schools. Improvement in the ability to predict suicide attempts through the identification of specific risk and protective factors experienced over the course of child and adolescent development is an important goal for the prevention of suicide.
描述(由申请人提供):这项探索性研究将使用两个正在进行的流行病学抽样队列的13波前瞻性纵向数据来检查是否存在自杀企图的独特途径,其中2953名年轻人(300名有既往自杀企图)最初是在马里兰州巴尔的摩的28所内城公立学校进入一年级时招募的。该项目将评估个体精神,家庭(养育,家族史),环境(暴露于暴力,性/身体虐待),社会和高风险行为(性,药物使用)在发展过程中对自杀企图的不同途径的影响。研究表明,预测自杀死亡和自杀企图是非常困难的,也许是因为有多种途径或亚型。亚型的识别非常重要,因为亚型的适当干预方法可能不同。SA亚型也可能代表更同质的遗传组,从而产生更大的能力来检测SA易感性的遗传变异。研究已经确定了风险和保护因素,但很少有通过发展过程前瞻性地确定多种因素,以确定过程或机制。在我们的社区样本中,大多数患有SA的参与者(约60%)从未达到DSM-IV的重度抑郁发作标准。越来越多的文献表明,特质攻击/冲动作为自杀风险的一个强有力的指标,具有可能的生物学基础。目前还不清楚是否有一个独特的亚组定义的特质侵略增加的责任SA。我们将研究参与者,同龄人,父母,教师和公共记录(逮捕记录)报告的儿童,青少年和年轻人经历的多个领域。该项目将评估自杀企图风险的特定遗传标记的影响(即,SLC 6A 4,TPH 1,BDNF,FKBP 5)的总体和亚组,基于发育途径或轨迹确定。这项研究的结果将推进我们目前对种族多样的城市社区人群中与自杀企图相关的过程和机制的理解。 公共卫生关系:这个R21项目题为“自杀企图的发展途径”,旨在确定不同的途径或轨迹,自杀企图在2953年的年轻人(300自杀未遂者)最初招募后进入一年级在巴尔的摩市公立学校。通过识别儿童和青少年发育过程中经历的特定风险和保护因素,提高预测自杀企图的能力,是预防自杀的一个重要目标。

项目成果

期刊论文数量(0)
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Holly C Wilcox其他文献

A Linguistic Analysis of Instagram Captions Between Adolescent Suicide Decedents and Living Controls.
对青少年自杀者和生活对照之间 Instagram 标题的语言分析。
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    3
  • 作者:
    Alex Walker;Ayah Zirikly;Melissa D. Stockbridge;Holly C Wilcox
  • 通讯作者:
    Holly C Wilcox
Identifying and characterizing suicide decedent subtypes using deep embedded clustering
利用深度嵌入式聚类识别和描述自杀死者亚型
  • DOI:
    10.1038/s41598-025-07007-4
  • 发表时间:
    2025-07-02
  • 期刊:
  • 影响因子:
    3.900
  • 作者:
    Anas Belouali;Christopher Kitchen;Ayah Zirikly;Paul Nestadt;Holly C Wilcox;Hadi Kharrazi
  • 通讯作者:
    Hadi Kharrazi

Holly C Wilcox的其他文献

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{{ truncateString('Holly C Wilcox', 18)}}的其他基金

Adaptation and Pilot Test of a Universal School-Based Suicide Prevention Program
普遍的基于学校的自杀预防计划的适应和试点测试
  • 批准号:
    10338185
  • 财政年份:
    2020
  • 资助金额:
    $ 26.64万
  • 项目类别:
Adaptation and Pilot Test of a Universal School-Based Suicide Prevention Program
普遍的基于学校的自杀预防计划的适应和试点测试
  • 批准号:
    10206479
  • 财政年份:
    2020
  • 资助金额:
    $ 26.64万
  • 项目类别:
Adaptation and Pilot Test of a Universal School-Based Suicide Prevention Program
普遍的基于学校的自杀预防计划的适应和试点测试
  • 批准号:
    10116490
  • 财政年份:
    2020
  • 资助金额:
    $ 26.64万
  • 项目类别:
Impact of Increasing Adolescent Depression Literacy on Treatment-Seeking Behavior
提高青少年抑郁素养对寻求治疗行为的影响
  • 批准号:
    8517202
  • 财政年份:
    2012
  • 资助金额:
    $ 26.64万
  • 项目类别:
Impact of Increasing Adolescent Depression Literacy on Treatment-Seeking Behavior
提高青少年抑郁素养对寻求治疗行为的影响
  • 批准号:
    8675948
  • 财政年份:
    2012
  • 资助金额:
    $ 26.64万
  • 项目类别:
Impact of Increasing Adolescent Depression Literacy on Treatment-Seeking Behavior
提高青少年抑郁素养对寻求治疗行为的影响
  • 批准号:
    8373584
  • 财政年份:
    2012
  • 资助金额:
    $ 26.64万
  • 项目类别:
Developmental Pathways to Suicide Attempt
自杀未遂的发展途径
  • 批准号:
    8208083
  • 财政年份:
    2011
  • 资助金额:
    $ 26.64万
  • 项目类别:
The Influence of Drug Use on Suicide Ideation & Attempts
吸毒对自杀意念的影响
  • 批准号:
    6555817
  • 财政年份:
    2002
  • 资助金额:
    $ 26.64万
  • 项目类别:
The Influence of Drug Use on Suicide Ideation & Attempts
吸毒对自杀意念的影响
  • 批准号:
    6406347
  • 财政年份:
    2001
  • 资助金额:
    $ 26.64万
  • 项目类别:

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