Studying the Biology and Behavior of Autism at 1-Year: The Well-Baby Check-Up App

研究自闭症一岁的生物学和行为：健康婴儿检查应用程序

• 批准号: 7994864
• 负责人: Karen L Pierce
• 金额: $ 27.22万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-17 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7994864
• 关键词: 1 year old; 2 year old; Address; Age; Age-Months; Anti-Inflammatory Agents; Anti-inflammatory; Area; Authorization documentation; Autistic Disorder; Back; Behavior; Behavioral; Biological; Biological Assay; Biology; Bioperiodicity; Birth; Budgets; Castes; Characteristics; Child; Child Development; Childhood; Clinical; Clinical Pathology; Cognitive; Communication; Data; Data Analyses; Daughter; Development; Developmental Delay Disorders; Diagnosis; Diagnostic; Disclosure; Disease; Early identification; Eating; Equilibrium; Ethics; Exhibits; Eye; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Gastroenteritis; Gifts; Goals; Grant; Growth Factor; Head circumference; Human Resources; Immune; Infant; Inflammatory; Irritable Bowel Syndrome; Judgment; Laboratories; Language; Life; Literature; Measures; Medical; Medical Records; Medical Staff; Methods; Modeling; Mothers; Normal Range; Outcome; Paper; Parents; Pattern; Performance; Phase; Plasma; Pregnancy; Principal Investigator; Procedures; Process; Prospective Studies; Psychometrics; Publications; Published Comment; Questionnaires; ROC Curve; Recruitment Activity; Reliance; Research; Research Personnel; Resources; Risk; Role; Sampling; Sampling Biases; Sampling Studies; Schools; Screening procedure; Siblings; Sleep; Son; Staging; Stress; Symptoms; TNF gene; Test Result; Testing; Time; Toddler; Translating; Visit; Work; autism spectrum disorder; brain size; brief screening; checkup examination; chemokine; cost; cytokine; design; deviant; early childhood; experience; falls; follow-up; gaze; high risk; high risk infant; human subject; improved; indexing; instrument; interest; joint attention; neuroinflammation; novel strategies; offspring; pediatrician; pre-clinical; preference; programs; prospective; response; social; social communication; standardize measure; success; suspected autism; tool; volunteer

DESCRIPTION (provided by applicant): There is a paucity of behavioral data and an absence of biological data on autism at 12 months of age. The reason for these major gaps in vital information is because autism remains behaviorally, not biologically, defined and diagnosed. Prospective, hypothesis- driven studies of behavior and biology in autistic infants would be powerful and are essential, but are missing. Currently, the infant sibling design is the only prospective approach in use. This design is strong but also has limitations including high costs, long-time scale, potential for sampling bias, and the heavy demands on the researcher to identify, recruit, and maintain contact long-term with large numbers of mothers and infants. We propose a different prospective strategy, called the "1-Year Well Baby Check-Up Approach", that does not involve any of these limitations. Because most babies see their pediatrician at 1 year, we propose to have 60 pediatricians give a brief screening questionnaire to parents while in the waiting room, the CSBS-DP Infant Toddler Checklist (Wetherby and Prizant, 2002), at every 1-year well baby check-up. Infants whose scores fall outside of the normal range will be referred to us for follow-up diagnostic and psychometric testing. Babies judged to be at-risk for autism or developmental delay (DD) will be followed longitudinally to determine the success rate of this procedure. Control subjects will be babies who score within the normal range on the checklist. Success of this model approach can have an immediate impact on pediatric practice. Babies judged to be at-risk for autism or DD, as well as controls, will participate in two studies aimed at demonstrating that important behavioral and biological information can be obtained via this approach. In one study, to address the important question of immunological abnormality in autism early in life, we will use state- of-the-art methods to assay plasma levels of specific immune significant cytokines and growth factors. In the second study, to address important questions about early social interest and orienting abnormalities in autism, we will use a quantitative experimental procedure for investigating social preference behavior and eye gaze patterns. Successful identification of biological and behavioral features of autism at 12 months of age will have a major impact by introducing the possibility of pediatric referral of high risk infants for quantitative and objective tests that can aid in earlier diagnostic and treatment decisions.7.

描述（由申请人提供）：缺乏 12 个月大时自闭症的行为数据和生物学数据。重要信息存在这些重大差距的原因是自闭症仍然是通过行为而非生物学来定义和诊断的。对自闭症婴儿的行为和生物学进行前瞻性、假设驱动的研究将是有力且必要的，但目前还缺乏。目前，婴儿兄弟姐妹设计是唯一使用的前瞻性方法。这种设计很强大，但也有局限性，包括成本高、时间跨度大、潜在的抽样偏差，以及对研究人员识别、招募和与大量母亲和婴儿保持长期接触的严格要求。我们提出了一种不同的前瞻性策略，称为“一年期婴儿健康检查方法”，该策略不涉及任何这些限制。由于大多数婴儿在 1 岁时就去看儿科医生，因此我们建议在每次 1 岁健康婴儿检查时，让 60 名儿科医生在候诊室向家长提供一份简短的筛查问卷，即 CSBS-DP 婴幼儿检查表（Wetherby 和 Prizant，2002 年）。分数超出正常范围的婴儿将被转介给我们进行后续诊断和心理测量测试。被判断为有自闭症或发育迟缓（DD）风险的婴儿将进行纵向随访，以确定该手术的成功率。对照对象是检查表上得分在正常范围内的婴儿。这种模型方法的成功可以对儿科实践产生直接影响。被判断为有自闭症或 DD 风险的婴儿以及对照婴儿将参加两项研究，旨在证明可以通过这种方法获得重要的行为和生物信息。在一项研究中，为了解决自闭症早期免疫异常的重要问题，我们将使用最先进的方法来测定特定免疫重要细胞因子和生长因子的血浆水平。在第二项研究中，为了解决有关自闭症早期社会兴趣和定向异常的重要问题，我们将使用定量实验程序来调查社会偏好行为和眼睛注视模式。成功识别 12 个月大时自闭症的生物学和行为特征将产生重大影响，因为引入了儿科转诊高危婴儿进行定量和客观测试的可能性，从而有助于早期诊断和治疗决策。7。