Translational Neuroscience Training Grant

转化神经科学培训补助金

• 批准号: 8039361
• 负责人: Stanley Thomas Carmichael
• 金额: $ 6.8万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-04 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8039361
• 关键词: Applications Grants; Basic Science; Brain Neoplasms; Budgets; Clinical; Clinical Sciences; Clinical Treatment; Collaborations; Communication; Communities; Development; Disease; Education; Environment; Epilepsy; Exposure to; Faculty; Funding; Genetic; Goals; Grant; Laboratories; Mentors; Modeling; Nature; Neurologist; Neurology; Neurosciences; Neurosciences Research; Oral; Parkinson Disease; Physicians; Postdoctoral Fellow; Production; Public Health; Relative (related person); Research; Residencies; Role; Scientist; Stroke; Structure; System; Time; Training; Training Programs; Translations; United States National Institutes of Health; Writing; career development; experience; flexibility; graduate student; human disease; innovation; nerve stem cell; neurosurgery; novel; progenitor; programs; public health relevance; symposium; technique development; translational neuroscience

DESCRIPTION (provided by applicant): Project Description: Physician-scientists occupy a critical niche in the translation of basic science findings into new clinical treatments. Within the field of neurology, physician-scientists have been at the forefront, among many examples, in developing new models of human disease, developing new clinical treatments for Parkinson's disease, epilepsy and stroke and identifying novel genetic signatures of brain tumors, glial progenitors and neural stem cells that may facilitate new therapies. However, the relative and absolute numbers of physician scientists have been declining over the past 25 years, despite the doubling of the NIH research budget during a portion of this epoch. This is in large part due to the prolonged nature of the training for a physician-scientist. The NIH has recognized this problem in the release of this RFA for Neurology and Neurosurgery Education Programs. The goal of the neurology research education program in this grant proposal is to train neurology residents in either basic or clinical science research through direct investigative study, oral/written scientific presentation, and intensive mentored career development. The structure of the training program incorporates two tiers of mentoring and focused time on oral and written presentations, with a culmination in the production of career development grant in the final year of the residency for each trainee. This training program is supported by an excellent environment for neuroscience research and education in the UCLA Neurology Department. The department has been the number 1 NIH funded neurology department since 2002, and has a large clinical and basic research faculty with diverse and well-funded programs. The residency program is relatively large (8 per year) with flexibility to place selected residents in a research program, and has a track record of training many academic neurologists in the past. The proposed education program leverages the existing research programs of the 61 mentors on this grant, and the past educational experience of the department, to develop novel basic and clinical science tutorials so as to provide technical training outside of primary research labs and to develop a larger translational neuroscience program within the neuroscience community at UCLA. This translational neuroscience program will be developed through didactics seminars, a translational neuroscience symposium and the formal investigative studies of the neurology residents on this proposed research track grant. In summary, the proposed training program in this grant develops a system of mentoring and scientific development for neurology resident trainees as well as serving as a focus for a larger environment in which to bring residents, graduate students and post-doctoral fellows into communication and collaboration around translational neuroscience training. Public Health Relevance: Physician-scientists have an important role in developing new therapies for disease. However, the numbers of physician-scientists have been declining. This grant develops a research program to train physician-scientists in neurology using an innovative program of laboratory training, exposure to cutting edge scientific techniques and development of a translational neuroscience environment. Relevance to Public Health: This grant will develop physician scientists in neurology that will develop new therapies for human diseases.

描述（由申请人提供）： 项目描述：医生兼科学家在将基础科学发现转化为新的临床治疗方法方面占据着关键地位。在神经病学领域，医师科学家在开发人类疾病的新模型、开发帕金森病、癫痫和中风的新临床治疗方法以及识别可能促进新疗法的脑肿瘤、神经胶质祖细胞和神经干细胞的新遗传特征等方面一直处于最前沿。然而，在过去 25 年里，尽管 NIH 的研究预算在这段时间的一段时间内翻了一番，但医师科学家的相对和绝对数量一直在下降。这在很大程度上是由于医师科学家的培训时间较长。 NIH 在发布神经病学和神经外科教育计划 RFA 时已经认识到了这个问题。本拨款提案中的神经病学研究教育计划的目标是通过直接调查研究、口头/书面科学演示和强化指导的职业发展来培训神经病学住院医师进行基础或临床科学研究。培训计划的结构包括两层指导和集中时间进行口头和书面演示，最终在每位学员实习的最后一年获得职业发展补助金。该培训项目得到了加州大学洛杉矶分校神经病学系良好的神经科学研究和教育环境的支持。自 2002 年以来，该系一直是 NIH 资助的第一大神经病学系，拥有庞大的临床和基础研究师资队伍，项目多样且资金充足。住院医师计划相对较大（每年 8 个），可以灵活地将选定的住院医师安排到研究计划中，并且过去有培训过许多学术神经科医生的记录。拟议的教育计划利用了该资助的 61 名导师的现有研究计划以及该系过去的教育经验，开发新颖的基础和临床科学教程，以便在初级研究实验室之外提供技术培训，并在加州大学洛杉矶分校的神经科学界内开发更大的转化神经科学计划。该转化神经科学项目将通过教学研讨会、转化神经科学研讨会和神经病学住院医师就这项拟议的研究方向拨款进行正式调查研究来开发。总之，这笔赠款中拟议的培训计划为神经病学住院医师实习生开发了一个指导和科学发展系统，并作为更大环境的焦点，使住院医师、研究生和博士后研究员围绕转化神经科学培训进行交流和合作。 公共卫生相关性：医师科学家在开发疾病新疗法方面发挥着重要作用。然而，医师科学家的数量一直在下降。这笔赠款开发了一项研究计划，通过创新的实验室培训计划、接触尖端科学技术和开发转化神经科学环境来培训神经病学领域的医师科学家。与公共卫生的相关性：这笔拨款将培养神经病学领域的医师科学家，为人类疾病开发新疗法。