Regulation of Cellular Growth and Differentiation

细胞生长和分化的调节

• 批准号: 8060115
• 负责人: Sohaib A. Khan
• 金额: $ 5.54万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8060115
• 关键词: Regulation; cell growth

This application is a competitive renewal for a training grant entitled "Regualtion of cellular growth and differentiation", originally funded in 1993. The goal of this grant proposal remains unchanged, that is to provide solid training to pre- and postdoctoral trainees in contemporary cancer biology, so that they can pursue independent careers in this discipline. A group of 19 investigators with clear focus in cancer research are seeking funds to train 4 predoctoral and 4 postdoctoral fellows through this program. The preceptors are derived from seven departments of the University of Cincinnati Medical Center. These include the Department of Cell Biology, Department of Environmental Health, Department of Developmental Biology, Department of Internal Medicine, Department of Molecular Genetics, Department of Genome Sciences, and Department of Molecular and Cellular Physiology. All of the training faculty members are well funded by NIH and other funding agencies, such as American Cancer Society and DOD Breast Cancer Program. Research supports of a majority of the training faculty come from National Cancer Institute. As detailed in the body of this proposal, active collaborations exist among the training grant faculty. With the strong backing of the Medical Center Administration, the cancer program has seen a remarkable growth in the past five years with new recruitments at the center. This has benefited the training grant and has improved our efforts to recruit trainees of higher caliber. Efforts to recruit the best trainees, including minority candidates will continue. Entering predoctoral candidates have undergraduate bachelor's degree in biological, chemical or physical sciences. Postdoctoral candidates must have a Ph.D., M.D., or D.V.M. and proven academic excellence. A well-defined training program, with new training approaches, is outlined for pre- and postdoctoral trainees that include mandatory participation in a course on Biology of Cancer, Cancer Journal Club, Cancer Seminar Series, "Awareness to Cancer Patient Care", Scientific Writing and Annual Retreat. The evaluation of the program and the progress of the trainees will be periodically reviewed by the Advisory and the Executive Committees. Past trainees of this program have gone on to careers in cancer research at excellent institutions. We are committed to produce well-trained researchers, who conform to the criteria for cancer research training envisioned by the NCI.

本申请是一个竞争性的更新，为培训补助金题为“调节细胞生长和 差异”，最初于1993年供资。这项拨款提案的目标保持不变，即 为当代癌症生物学的博士前和博士后学员提供扎实的培训，使他们能够 在这个学科中追求独立的职业生涯。一个由19名研究人员组成的小组， 正在寻求资金，通过该计划培养4名博士前和4名博士后研究员。导师是 来自辛辛那提大学医学中心的七个部门。其中包括 细胞生物学系，环境卫生系，发育生物学系， 内科学系、分子遗传学系、基因组科学系、 分子与细胞生理学系。所有的培训教员都得到了NIH的资助 和其他资助机构，如美国癌症协会和国防部乳腺癌计划。研究 大多数培训教师的支持来自国家癌症研究所。如正文所述， 根据这项建议，培训补助金教员之间开展了积极合作。有了强大的后盾， 医疗中心管理局，癌症计划已经看到了显着的增长，在过去五年中， 中心的新招聘。这使培训补助金受益，并改善了我们的征聘工作 更高水平的学员。将继续努力征聘最好的受训人员，包括少数族裔候选人。 进入博士预科候选人有本科学士学位，生物，化学或物理 以理工科为重博士后候选人必须具有博士学位，医学博士，或DVM和被证明的学术卓越。一 明确的培训计划，与新的培训方法，概述了前和博士后学员 其中包括强制参加癌症生物学课程、癌症杂志俱乐部、癌症研讨会 系列，“癌症病人护理意识”，科学写作和年度务虚会。的评价 顾问和执行人员将定期审查培训计划和受训人员的进展情况 委员会。该计划的过去学员已经在优秀的癌症研究中继续职业生涯 机构职能体系我们致力于培养符合癌症标准的训练有素的研究人员 NCI设想的研究培训。

项目成果

Altered serotonin physiology in human breast cancers favors paradoxical growth and cell survival.

• DOI: 10.1186/bcr2448
• 发表时间: 2009
• 期刊: Breast cancer research : BCR
• 作者: Pai VP;Marshall AM;Hernandez LL;Buckley AR;Horseman ND
• 通讯作者: Horseman ND

β-Catenin is required for Ron receptor-induced mammary tumorigenesis.

• DOI: 10.1038/onc.2011.86
• 发表时间: 2011-08-25
• 期刊: ONCOGENE
• 影响因子: 8
• 作者: Wagh, P. K.;Gray, J. K.;Zinser, G. M.;Vasiliauskas, J.;James, L.;Monga, S. P.;Waltz, S. E.
• 通讯作者: Waltz, S. E.

Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo.

• DOI: 10.1158/0008-5472.can-08-2304
• 发表时间: 2009-03-01
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Wise-Draper TM;Mintz-Cole RA;Morris TA;Simpson DS;Wikenheiser-Brokamp KA;Currier MA;Cripe TP;Grosveld GC;Wells SI
• 通讯作者: Wells SI

E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms.

• DOI: 10.1242/jcs.110.3.345
• 发表时间: 1997-02
• 期刊: Journal of cell science
• 影响因子: 4
• 作者: Haiyan Chen;N. Paradies;M. Fedor-Chaiken;R. Brackenbury

Expression of N-cadherin and alpha-catenin in astrocytomas and glioblastomas.

N-钙粘着蛋白和α-钙蛋白在星形胶质细胞瘤和胶质母细胞瘤中的表达。

• DOI: 10.1038/bjc.1995.384
• 发表时间: 1995-09
• 期刊: BRITISH JOURNAL OF CANCER
• 影响因子: 8.8
• 作者: Shinoura, N;Paradies, N E;Warnick, R E;Chen, H;Larson, J J;Tew, J J;Simon, M;Lynch, R A;Kanai, Y;Hirohashi, S
• 通讯作者: Hirohashi, S