Tensor Computations for Modeling Large-Scale Molecular Biological Data

用于大规模分子生物学数据建模的张量计算

• 批准号: 8212604
• 负责人: Orly Alter
• 金额: $ 30.51万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-23 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8212604
• 关键词: Alcoholism; Algorithms; Biological; Biological Process; Biology; Brain; Cancer Biology; Cell Cycle; Cell Proliferation; Cell physiology; Code; Computer software; DNA; DNA Binding; DNA Microarray Chip; DNA copy number; DNA-Binding Proteins; Data; Data Set; Eukaryota; Eukaryotic Cell; Foundations; Fourier Transform; Future; Genes; Genetic Transcription; Genome; Genomics; Goals; Gravitation; High Performance Computing; Human; Internet; Laboratories; Life; Malignant Neoplasms; Measures; Medicine; Messenger RNA; Meta-Analysis; Modeling; Molecular; Motion; Nature; Neurosciences; Organism; Orthologous Gene; Pathway interactions; Pattern; Pheromone; Physics; Process; Property; Proteins; Proteomics; RNA; Regulation; Replication Initiation; Research; Research Personnel; Scheme; Sequence Alignment; Signal Transduction; Statistical Models; Structure; System; Testing; Time; Tissue Sample; Transcript; Variant; Work; Yeasts; addiction; austin; base; biological systems; comparative; computerized data processing; functional genomics; gel electrophoresis; genome-wide; high throughput technology; insight; mRNA Expression; mathematical model; molecular scale; novel; parallel computing; physical process; platform-independent; predictive modeling; programs; research study; response; success; tool; transcription factor; trend; web site

项目成果

Global effects of DNA replication and DNA replication origin activity on eukaryotic gene expression.

• DOI: 10.1038/msb.2009.70
• 发表时间: 2009
• 期刊: Molecular systems biology
• 影响因子: 9.9

Tensor GSVD of patient- and platform-matched tumor and normal DNA copy-number profiles uncovers chromosome arm-wide patterns of tumor-exclusive platform-consistent alterations encoding for cell transformation and predicting ovarian cancer survival.

• DOI: 10.1371/journal.pone.0121396
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Sankaranarayanan P;Schomay TE;Aiello KA;Alter O
• 通讯作者: Alter O

A higher-order generalized singular value decomposition for comparison of global mRNA expression from multiple organisms.

• DOI: 10.1371/journal.pone.0028072
• 发表时间: 2011
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Ponnapalli SP;Saunders MA;Van Loan CF;Alter O
• 通讯作者: Alter O

SVD identifies transcript length distribution functions from DNA microarray data and reveals evolutionary forces globally affecting GBM metabolism.

• DOI: 10.1371/journal.pone.0078913
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Bertagnolli NM;Drake JA;Tennessen JM;Alter O
• 通讯作者: Alter O