MOLECULAR AND STRUCTURAL BASES OF HYPOTHALAMIC PUBERTY

下丘脑青春期的分子和结构基础

• 批准号: 8173211
• 负责人: Sergio R Ojeda
• 金额: $ 4.76万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173211
• 关键词: Adolescent; Computer Retrieval of Information on Scientific Projects Database; Development; Feedback; Funding; Gene Expression; Grant; Human; Hypothalamic structure; Institution; Macaca mulatta; Molecular; Phase; Physiological; Puberty; Research; Research Personnel; Resources; Source; Testicular Hormones; Time; United States National Institutes of Health; base; infancy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a subcontract aimed at understanding the physiological mechanisms responsible for the onset of puberty in humans. Studies performed in Dr. Ojeda's lab are those proposed under Specific Aim 3 of the main application, which is: "To determine, in the absence of interfering testicular hormone feedback, the global profile of hypothalamic gene expression at the time of 1) the suppression of pulsatile GnRH release during infancy, and 2) the resurgence in pulsatile GnRH release at the end of the juvenile phase of development". The rhesus monkey is being used as an experimental paradigm.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一个分包合同，旨在了解导致人类青春期开始的生理机制。在Ojeda博士的实验室进行的研究是在主要应用的特定目标3下提出的，即：“在没有干扰睾丸激素反馈的情况下，确定下丘脑基因表达的全球概况：1)婴儿时期GnRH脉动性释放的抑制，以及2)幼年发育阶段末期脉动性GnRH释放的回升”。恒河猴被用作实验范例。