AIDS MACAQUE RESOURCE

艾滋病猕猴资源

• 批准号: 8173234
• 负责人: Louis J. Picker
• 金额: $ 9.51万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173234
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Antiviral Agents; Chimera organism; Clinical Management; Communities; Computer Retrieval of Information on Scientific Projects Database; Disease; Disease Resistance; Enrollment; Funding; Grant; HIV; HIV Infections; Immune system; Infection; Institution; Life; Macaca; Methods; Modeling; Pathogenesis; Population; Research; Research Personnel; Resources; SIV; Source; Treatment Protocols; United States National Institutes of Health; Vaccinated; Vaccines; Virus Replication; disorder control; prevent; programs; simian human immunodeficiency virus; vaccine evaluation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Clinical management of HIV disease is focused on controlling virus replication through the use of antiviral drugs. While major advances have been made in developing new, more effective antiviral drug and treatment regimens, a vaccine that would protect against HIV infection or boost the immune system to a level that infection can be controlled and the disease state eliminated is widely held as the best method of controlling HIV infection. To date, the simian immunodeficiency virus/simian-human immunodeficiency virus chimera (SIV/SHIV) macaque models have the best research record for defining mechanisms of HIV pathogenesis and for testing vaccines capable of preventing AIDS disease. The objective of this resource is to maintain a pool of unique, long-term surviving SIV/SHIV-infected control and vaccinated macaques that have out-lived the objectives of their original studies in order that they may be studied further for their potential contribution to understanding mechanisms of innate disease resistance and/or vaccine-induced disease resistance. The animals enrolled in the AIDS Macaque Resource represent a unique population of animals that have on average 3-4 years of research effort and funding invested in them that would be lost to the research community without the proposed resource project. This resource continues to be provide invaluable support to our AIDS research program.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 HIV疾病的临床管理专注于通过使用抗病毒药物来控制病毒复制。 尽管在开发新的，更有效的抗病毒药和治疗方案方面已取得了重大进展，但一种可以预防HIV感染或将免疫系统促进可控制感染水平的疫苗，并且消除疾病状态被广泛视为控制HIV感染的最佳方法。 迄今为止，Simian免疫缺陷病毒/Simian-Human免疫缺陷病毒嵌合体（SIV/SHIV）猕猴模型具有定义HIV发病机理和测试能够预防艾滋病疾病的疫苗机制的最佳研究记录。 该资源的目的是维持独特的，长期存活的SIV/SHIV感染的控制和接种猕猴，这些猕猴已经超出了其原始研究的目标，以便可以进一步研究它们，以了解其潜在的贡献，以了解理解先天性疾病耐药性和/或疫苗诱发疾病抗性的机制。 参加艾滋病猕猴资源的动物代表了独特的动物种群，这些动物平均投入了3 - 4年的研究工作和资金，而没有提议的资源项目，这些动物将丢失给研究社区。该资源继续为我们的艾滋病研究计划提供宝贵的支持。