COMPARATIVE STUDIES OF AGING
衰老的比较研究
基本信息
- 批准号:8172417
- 负责人:
- 金额:$ 5.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-05-01 至 2011-04-30
- 项目状态:已结题
- 来源:
- 关键词:AffectAgingAging-Related ProcessAlzheimer&aposs DiseaseBehavioralBrain regionChildhoodClinicCognitiveCognitive agingComparative StudyComputer Retrieval of Information on Scientific Projects DatabaseDevelopmentDiseaseElementsFosteringFundingGrantHippocampal FormationHomo sapiensHumanInstitutesInstitutionLightLinkMacaca mulattaMonkeysPan GenusPan troglodytesPatientsPatternPerformancePrefrontal CortexPrimatesResearchResearch PersonnelResourcesSeriesSourceTask PerformancesTechnologyTestingTherapeutic InterventionUnited States National Institutes of Healthage relatedaging brainbehavior testcognitive functiondesignhuman subjectin vivomild neurocognitive impairmentneuroimagingnonhuman primate
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
This project compares trajectories of cognitive and brain aging in Homo sapiens with the pattern of aging in two closely related primate species, Pan troglodytes and Macaca mulatta. One key element of the project is the construct validity study being carried out at Georgia Institute of Technology under the direction of Dr. Anderson Smith. Approximately 200 normal human subjects have been tested in this study to examine the validity of widely used monkey tasks in assessing performance on specific domains of human cognitive function.
This portion of the study has demonstrated that there are indeed age-related changes in humans that negatively affect performance of those tasks developed for the non human primate (NHP). Analyses are now underway to determine whether declines in performance of these tasks correlate with declines in tasks in common use in the studies of human cognitive aging. The NHP studies involve 36 chimpanzees and 24 rhesus monkeys. Each NHP undergoes a behavioral test battery designed to assess specific aspects of cognitive functioning that can be linked to brain regions such as the dorsolateral prefrontal cortex (dlPFC) or the hippocampal formation. In addition, we have recently added a series of tasks for the chimpanzee that have been used in comparative studies of childhood and development in humans and chimpanzees.
During the past project year, we have also refined and developed the set of tasks that are to be used with healthy humans, as well as in humans with Mild Cognitive Impairment of the amnestic variety and in patients with Alzheimer's disease.
These behavioral studies, as well as complementary in vivo neuroimaging studies, will shed light upon the differences in cognitive and aging processes that foster the human-specific pattern of aging and disease and will therefore inform strategies of therapeutic intervention in the human clinic.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
该项目比较了智人的认知和大脑衰老轨迹与两种密切相关的灵长类物种Pan troglodytes和Macaca mulatta的衰老模式。 该项目的一个关键要素是在安德森史密斯博士的指导下在格鲁吉亚理工学院进行的结构有效性研究。 在这项研究中,对大约200名正常人类受试者进行了测试,以检查广泛使用的猴子任务在评估人类认知功能特定领域的表现方面的有效性。
研究的这一部分已经证明,人类确实存在与年龄相关的变化,这些变化对非人类灵长类动物(NHP)开发的任务的表现产生了负面影响。 目前正在进行分析,以确定这些任务的表现下降是否与人类认知老化研究中常用的任务下降相关。 NHP研究涉及36只黑猩猩和24只恒河猴。 每个NHP都要接受一系列行为测试,旨在评估认知功能的特定方面,这些方面可能与大脑区域有关,如背外侧前额叶皮层(dlPFC)或海马结构。 此外,我们最近为黑猩猩增加了一系列任务,这些任务已被用于人类和黑猩猩童年和发育的比较研究。
在过去的项目年中,我们还改进和开发了一套用于健康人的任务,以及用于遗忘型轻度认知障碍患者和阿尔茨海默病患者的任务。
这些行为研究以及补充的体内神经成像研究将揭示认知和衰老过程的差异,这些差异促进了人类特定的衰老和疾病模式,因此将为人类临床的治疗干预策略提供信息。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JAMES G HERNDON其他文献
JAMES G HERNDON的其他文献
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{{ truncateString('JAMES G HERNDON', 18)}}的其他基金
STUDIES OF AGING AND COGNITION IN NONHUMAN PRIMATES
非人类灵长类动物的衰老和认知研究
- 批准号:
8357375 - 财政年份:2011
- 资助金额:
$ 5.48万 - 项目类别:
STUDIES OF AGING AND COGNITION IN NONHUMAN PRIMATES
非人类灵长类动物的衰老和认知研究
- 批准号:
8172302 - 财政年份:2010
- 资助金额:
$ 5.48万 - 项目类别:
STUDIES OF AGING AND COGNITION IN NONHUMAN PRIMATES
非人类灵长类动物的衰老和认知研究
- 批准号:
7958101 - 财政年份:2009
- 资助金额:
$ 5.48万 - 项目类别:
STUDIES OF AGING AND COGNITION IN NONHUMAN PRIMATES
非人类灵长类动物的衰老和认知研究
- 批准号:
7715663 - 财政年份:2008
- 资助金额:
$ 5.48万 - 项目类别:
SELECTIVE ESTROGEN RECEPTOR MODULATORS AND COGNITION
选择性雌激素受体调节剂和认知
- 批准号:
7562593 - 财政年份:2007
- 资助金额:
$ 5.48万 - 项目类别:
Evolution of Aging and Dementia in Female Primates
雌性灵长类动物衰老和痴呆的进化
- 批准号:
7184570 - 财政年份:2007
- 资助金额:
$ 5.48万 - 项目类别:
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