COMPARATIVE STUDIES OF AGING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是研究衰老过程如何不同地影响三种密切相关的灵长类动物物种的女性：人类，黑猩猩和恒河猴。 这一进化过程导致了人类衰老表型的独特特征，通过将人类的大脑和认知衰老与我们最近的亲戚黑猩猩以及研究最广泛的人类衰老生物医学模型恒河猴的相同特征进行比较，可以最好地理解这一点。在这三个物种中使用可比的措施，并采用横截面和纵向研究，我们开发了一个全面的和综合的概述，社会，认知和神经衰老在这三个密切相关的旧世界灵长类动物。 在报告期内，我们对猴子和黑猩猩进行了一系列行为测试，包括学习和记忆测试，并对黑猩猩进行了社会情感认知测试。 我们测量了人类与年龄相关的认知功能，使用的测试与我们在非人类灵长类动物中使用的测试相同。 我们的实验室进行了磁共振扫描，旨在检查这三个物种的大脑白色物质。 这些数据将为与年龄相关的认知衰退的神经基础以及控制成功与不成功衰老的因素提供新的见解。这种对人类和非人类灵长类动物的比较分析也应该有助于解释为什么人类会患上老年痴呆症等与年龄有关的疾病，而猴子和猿却不会。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study has been to examine how the aging process differentially affects females of three closely related primate species: the human, the chimpanzee, and the rhesus monkey. This evolutionary process has led to unique characteristics of the aging phenotype of the human, which can be best understood by comparing brain and cognitive aging in the human with the same features in our closest relative, the chimpanzee, and in the most widely studied biomedical model of human aging, the rhesus monkey. Using comparable measures in these three species and employing both cross-sectional and longitudinal studies, we developed a comprehensive and integrated overview of social, cognitive, and neural aging in these three closely related Old World primates. During the reporting period, we conducted a series of behavioral tests on the monkeys and chimpanzees, including tests of learning and memory and performed a test of socio-emotional cognition on chimpanzees. We have measured age-related cognitive function in humans, using the same tests we employed in the nonhuman primates. Our lab carried out MR scans designed to examine brain white matter in the three species. The data will provide new insights into the neural basis of age-related cognitive decline and into the factors that govern successful versus unsuccessful aging. This comparative analysis of human and nonhuman primates should also help explain why humans develop such age-related disorders as Alzheimer's disease, while monkeys and apes do not.