Vasopressin Effects on Emotional Social Communication

加压素对情感社交沟通的影响

• 批准号: 8119690
• 负责人: JAMES K RILLING
• 金额: $ 37.46万
• 依托单位: BOWDOIN COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8119690
• 关键词: Affect; Aggressive behavior; Anger; Animal Model; Antisocial Personality Disorder; Argipressin; Autistic Disorder; Behavior; Biological Neural Networks; Brain; Clinical; Communication; Disease; Dose; Emotional; Emotional Disturbance; Evolution; Face; Facial Expression; Female; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Future; Gender; Genotype; Homologous Gene; Human; Individual; Individual Differences; Knowledge; Measures; Molecular; Peptides; Personality Disorders; Play; Population; Process; Promoter Regions; Receptor Gene; Regulation; Role; Signal Transduction; Smiling; Social Behavior; Social Environment; Social Interaction; Specificity; Stimulus; Symptoms; System; Techniques; Testing; Translating; Variant; Vasopressins; Vasotocin; Vertebrates; Woman; Work; affiliative behavior; anti social; gene therapy; insight; male; men; neurochemistry; novel; public health relevance; receptor; relating to nervous system; research study; response; sex; social; social communication

DESCRIPTION (provided by applicant): Arginine vasopressin (AVP) and related peptides have profound influences on social behaviors in vertebrates, particularly on emotional aggressive and affiliative interactions between individuals. Although we have recently shown that AVP can promote antisocial responses towards same-sex social stimuli in men and affiliative responses towards same-sex social stimuli in women, we do not yet know if there are sexually dimorphic AVP circuits that promote different social responses in the sexes, or rather if AVP's antisocial and affiliative effects depend on social context, specifically whether the social stimulus is male or female. The first aim of this application is therefore to measure the effects of intranasal AVP on emotional responses to same and other sex faces in men and women to see if AVP produces antisocial effects towards males and affiliative effects towards females, or rather if AVP uniformly promotes antisocial responses in males and affiliative responses in females. This will be done by measuring the effects of AVP on somatic responses associated with anger and threat (contractions of the corrugator supercilii) and with affiliation (contractions of the zygomaticus major, which control smiling) when subjects view the faces of same and other sex individuals, and by measuring the effects of AVP on perceptual responses to those faces, particularly on ratings of friendliness / approachability. We will also determine the dose-responsiveness for these effects, and determine if the magnitude of AVP's antisocial and/or affiliative effects depend on background genotype, particularly on allelic variations in the polymorphic RS3 promoter region of the AVP V1a receptor gene. Finally, we will identify regions in the brain where responses to those social stimuli change as a function of AVP administration. Together, these studies will elucidate the context and gender specificity of AVP's effects on emotional social communication in humans, as well as the molecular and neuroanatomical mechanisms associated with those effects. Ultimately, these studies will not only increase our understanding of the neurochemical mechanisms associated with normal social / emotional regulation in humans, but also our understanding of how dysfunctions within one of those systems may contribute to disorders characterized by social / emotional disturbances. PUBLIC HEALTH RELEVANCE: By determining if arginine vasopressin (AVP) can influence emotional social communication in men and women, particularly if it promotes antisocial and/or affiliative responses to social stimuli in men and women, the studies associated with this application will ultimately help us better understand and treat individuals with disorders that affect emotional social regulation, most notably those with autism and/or antisocial personality disorder. In fact, these studies could ultimately help develop pharmacological and/or genetic therapies that could help alleviate some of the otherwise intractable symptoms associated with these disorders.

描述（由申请人提供）：精氨酸加压素（AVP）和相关肽对脊椎动物的社会行为具有深远的影响，特别是对个体之间的情绪攻击和亲和互动。尽管我们最近表明AVP可以促进男性对同性社会刺激的反社会反应和女性对同性社会刺激的亲和反应，但我们还不知道是否存在促进性别不同社会反应的性别二态性AVP回路，或者更确切地说，AVP的反社会和亲和效应是否取决于社会背景，特别是社会刺激是男性还是女性。因此，本应用的首要目的是测量鼻内 AVP 对男性和女性对同性和异性面孔的情绪反应的影响，看看 AVP 是否对男性产生反社会效应，对女性产生亲和效应，或者更确切地说，AVP 是否一致促进男性的反社会反应和女性的亲和反应。当受试者看到同性和异性个体的面孔时，通过测量 AVP 对与愤怒和威胁（皱眉肌收缩）和亲和力（控制微笑的颧大肌收缩）相关的躯体反应的影响，并通过测量 AVP 对这些面孔的感知反应的影响，特别是对友善/可接近性的评级来完成。我们还将确定这些效应的剂量反应性，并确定 AVP 的反社会和/或亲和效应的程度是否取决于背景基因型，特别是 AVP V1a 受体基因多态性 RS3 启动子区域的等位基因变异。最后，我们将确定大脑中对这些社交刺激的反应随着 AVP 管理而变化的区域。这些研究将共同​​阐明 AVP 对人类情感社交沟通影响的背景和性别特异性，以及与这些影响相关的分子和神经解剖学机制。最终，这些研究不仅将增加我们对与人类正常社交/情绪调节相关的神经化学机制的理解，而且还将加深我们对这些系统之一的功能障碍如何导致以社交/情绪障碍为特征的疾病的理解。 公共健康相关性：通过确定精氨酸加压素（AVP）是否可以影响男性和女性的情绪社交沟通，特别是如果它促进男性和女性对社会刺激的反社会和/或亲和反应，与该应用相关的研究最终将帮助我们更好地理解和治疗患有影响情绪社会调节的疾病的个体，尤其是患有自闭症和/或反社会人格障碍的个体。事实上，这些研究最终可能有助于开发药理学和/或基因疗法，有助于缓解与这些疾病相关的一些棘手症状。