Vasopressin Effects on Emotional Social Communication

加压素对情感社交沟通的影响

• 批准号: 8119690
• 负责人: JAMES K RILLING
• 金额: $ 37.46万
• 依托单位: BOWDOIN COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8119690
• 关键词: Affect; Aggressive behavior; Anger; Animal Model; Antisocial Personality Disorder; Argipressin; Autistic Disorder; Behavior; Biological Neural Networks; Brain; Clinical; Communication; Disease; Dose; Emotional; Emotional Disturbance; Evolution; Face; Facial Expression; Female; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Future; Gender; Genotype; Homologous Gene; Human; Individual; Individual Differences; Knowledge; Measures; Molecular; Peptides; Personality Disorders; Play; Population; Process; Promoter Regions; Receptor Gene; Regulation; Role; Signal Transduction; Smiling; Social Behavior; Social Environment; Social Interaction; Specificity; Stimulus; Symptoms; System; Techniques; Testing; Translating; Variant; Vasopressins; Vasotocin; Vertebrates; Woman; Work; affiliative behavior; anti social; gene therapy; insight; male; men; neurochemistry; novel; public health relevance; receptor; relating to nervous system; research study; response; sex; social; social communication

DESCRIPTION (provided by applicant): Arginine vasopressin (AVP) and related peptides have profound influences on social behaviors in vertebrates, particularly on emotional aggressive and affiliative interactions between individuals. Although we have recently shown that AVP can promote antisocial responses towards same-sex social stimuli in men and affiliative responses towards same-sex social stimuli in women, we do not yet know if there are sexually dimorphic AVP circuits that promote different social responses in the sexes, or rather if AVP's antisocial and affiliative effects depend on social context, specifically whether the social stimulus is male or female. The first aim of this application is therefore to measure the effects of intranasal AVP on emotional responses to same and other sex faces in men and women to see if AVP produces antisocial effects towards males and affiliative effects towards females, or rather if AVP uniformly promotes antisocial responses in males and affiliative responses in females. This will be done by measuring the effects of AVP on somatic responses associated with anger and threat (contractions of the corrugator supercilii) and with affiliation (contractions of the zygomaticus major, which control smiling) when subjects view the faces of same and other sex individuals, and by measuring the effects of AVP on perceptual responses to those faces, particularly on ratings of friendliness / approachability. We will also determine the dose-responsiveness for these effects, and determine if the magnitude of AVP's antisocial and/or affiliative effects depend on background genotype, particularly on allelic variations in the polymorphic RS3 promoter region of the AVP V1a receptor gene. Finally, we will identify regions in the brain where responses to those social stimuli change as a function of AVP administration. Together, these studies will elucidate the context and gender specificity of AVP's effects on emotional social communication in humans, as well as the molecular and neuroanatomical mechanisms associated with those effects. Ultimately, these studies will not only increase our understanding of the neurochemical mechanisms associated with normal social / emotional regulation in humans, but also our understanding of how dysfunctions within one of those systems may contribute to disorders characterized by social / emotional disturbances. PUBLIC HEALTH RELEVANCE: By determining if arginine vasopressin (AVP) can influence emotional social communication in men and women, particularly if it promotes antisocial and/or affiliative responses to social stimuli in men and women, the studies associated with this application will ultimately help us better understand and treat individuals with disorders that affect emotional social regulation, most notably those with autism and/or antisocial personality disorder. In fact, these studies could ultimately help develop pharmacological and/or genetic therapies that could help alleviate some of the otherwise intractable symptoms associated with these disorders.

描述(申请人提供)：精氨酸加压素(AVP)和相关的多肽对脊椎动物的社会行为有深远的影响，特别是对个体之间的情感攻击性和从属互动。尽管我们最近发现AVP可以促进男性对同性社会刺激的反社会反应和女性对同性社会刺激的联系反应，但我们还不知道AVP是否存在促进性别不同社会反应的性二态AVP回路，或者AVP的反社会和附属效应是否依赖于社会背景，特别是社会刺激是男性还是女性。因此，这项应用的第一个目的是测量鼻腔AVP对男性和女性对同性和异性面孔的情绪反应的影响，以了解AVP是否对男性产生反社会效应，对女性产生从属效应，或者更确切地说，AVP是否统一地促进男性的反社会反应和女性的从属反应。这将通过测量AVP对与愤怒和威胁(皱眉肌收缩)和与联系(控制微笑的颧大肌收缩)相关的躯体反应的影响，以及通过测量AVP对这些面孔的知觉反应的影响，特别是对友好/亲近的评级。我们还将确定这些效应的剂量-反应关系，并确定AVP的反社会和/或附属效应的大小是否取决于背景基因，特别是AVP V1a受体基因RS3启动子区的等位基因变异。最后，我们将确定大脑中对这些社会刺激的反应随着AVP管理的功能而发生变化的区域。总之，这些研究将阐明AVP对人类情感社会交流的影响的背景和性别特异性，以及与这些影响相关的分子和神经解剖学机制。最终，这些研究不仅将增加我们对与人类正常的社会/情绪调节相关的神经化学机制的理解，还将增加我们对这些系统中的一个系统的功能障碍如何导致以社会/情绪障碍为特征的疾病的理解。 公共卫生相关性：通过确定精氨酸加压素(AVP)是否可以影响男性和女性的情绪社交交流，特别是如果它促进男性和女性对社会刺激的反社会和/或从属反应，与这一应用相关的研究最终将帮助我们更好地了解和治疗患有影响情绪社会调节的障碍的个人，最明显的是自闭症和/或反社会人格障碍。事实上，这些研究最终可能有助于开发药物和/或基因疗法，有助于缓解与这些疾病相关的一些本来难以治愈的症状。