Neurobiological bases of paternal nurturance
父亲养育的神经生物学基础
基本信息
- 批准号:8622249
- 负责人:
- 金额:$ 23.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-04-15 至 2016-03-31
- 项目状态:已结题
- 来源:
- 关键词:3 year oldAcousticsAdolescenceAggressive behaviorBehaviorBehavioralBrainChildChild DevelopmentChild Mental HealthCodeCognitiveConduct DisorderCryingDataDepressed moodDevelopmentDropsElectronicsFathersFunctional Magnetic Resonance ImagingHourImageInfantInterventionLifeMeasuresMethodsMinorityNeurobiologyOutcomeParticipantPaternal BehaviorPhysiologyPlacebosPostpartum DepressionRecordsRisk BehaviorsSamplingScanningSchoolsSocial EnvironmentSocial InteractionSocietiesStimulusSubstance abuse problemVariantbasedigitalhigh risk sexual behaviorimprovedkillingsnatural flowneuroimagingnovelphysical conditioningpsychological outcomespublic health relevancerelating to nervous systemresponsesocialsound
项目摘要
In modern, western societies like ours, being raised without a father is associated with a host of negative
developmental outcomes for children, including substance abuse, aggression and conduct disorder, dropping
out of school and risky sexual behavior in adolescence. When fathers are present, however, they are not
always helpful, and a small minority are even abusive. On the other hand, children raised by sensitive,
nurturing fathers have better cognitive, behavioral, social and psychological outcomes. The proposed project
will investigate the neurobiology underlying sensitive fathering and determine whether a pharmacological
intervention can enhance it. The first aim is to investigate the relationship between fathers' neural responses to
infant picture and cry stimuli and actual behavior of fathers in everyday life as assessed by the Electronic
Activated Recorder (EAR), a portable digital audio recorder that periodically records brief snippets of ambient
sounds and unobtrusively samples acoustic observations of participants' momentary social environments and
interactions within the natural flow of their lives. This aim will use previously collected EAR data from 60 fathers
of 1-3 year old children to code several measures of paternal behavior. Measures of paternal behavior will then
be correlated with previously collected neuroimaging data from the same fathers. Aim 2 will determine if
intranasal OT or AVP alter paternal neural responses to own child picture and cry stimuli. Thirty fathers with 1-
3 year old children will be imaged with fMRI as they view pictures of their own and unknown children and as
they listen to unknown infant cry stimuli. Fathers will be scanned on two separate occasions; once under the
influence of OT (n=15) or AVP (n=15), and once under the influence of a placebo. Order of administration will
be counterbalanced across subjects. Ultimately, it is hoped that interventions like these will improve children's
mental and physical health by virtue of their effects on the brain physiology and behavior of at-risk fathers (e.g.,
abusive fathers, fathers with post-partum depression).
在像我们这样的现代西方社会,没有父亲的抚养会带来许多负面影响。
儿童的发展结果,包括药物滥用、攻击性和行为障碍,
以及青少年时期的危险性行为。然而,当父亲在场时,
总是乐于助人,少数人甚至是虐待。另一方面,由敏感,
养育子女的父亲在认知、行为、社会和心理方面的结果更好。拟建项目
将研究神经生物学潜在的敏感父亲,并确定是否有一个药理学
第一个目的是研究父亲的神经反应与父亲的行为之间的关系,
婴儿图片和哭泣刺激和父亲在日常生活中的实际行为,
Activated Recorder(激活录音机),一种便携式数字录音机,定期记录周围环境的简短片段
声音和不引人注目的样本参与者的瞬时社会环境的声学观察,
在他们生命的自然流动中相互作用。这个目标将使用以前收集的60名父亲的数据
对1-3岁儿童的父亲行为进行编码。衡量父亲行为的标准
与先前从相同父亲收集的神经成像数据相关。目标2将确定是否
鼻内OT或AVP改变父亲对自己孩子图片和哭泣刺激的神经反应。30个父亲,1-
3岁的孩子将被成像与功能磁共振成像,因为他们看到自己的照片和未知的孩子,
他们听未知的婴儿哭声刺激。父亲将在两个不同的场合进行扫描;一次是在
OT(n=15)或AVP(n=15)的影响,以及一次在安慰剂的影响下。行政命令将
在各个学科之间进行平衡。最终,希望像这样的干预措施将改善儿童的
精神和身体健康由于其对处于危险中的父亲的大脑生理和行为的影响(例如,
虐待父亲,患有产后抑郁症的父亲)。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JAMES K RILLING其他文献
JAMES K RILLING的其他文献
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{{ truncateString('JAMES K RILLING', 18)}}的其他基金
OXTR Methylation as a Potential Modulator of Intranasal OT Influences in Humans
OXTR 甲基化作为人类鼻内 OT 影响的潜在调节剂
- 批准号:
8769006 - 财政年份:2014
- 资助金额:
$ 23.99万 - 项目类别:
Vasopressin Effects on Emotional Social Communication
加压素对情感社交沟通的影响
- 批准号:
8336958 - 财政年份:2010
- 资助金额:
$ 23.99万 - 项目类别:
Vasopressin Effects on Emotional Social Communication
加压素对情感社交沟通的影响
- 批准号:
8471197 - 财政年份:2010
- 资助金额:
$ 23.99万 - 项目类别:
Vasopressin Effects on Emotional Social Communication
加压素对情感社交沟通的影响
- 批准号:
8119690 - 财政年份:2010
- 资助金额:
$ 23.99万 - 项目类别:
Vasopressin Effects on Emotional Social Communication
加压素对情感社交沟通的影响
- 批准号:
7988381 - 财政年份:2010
- 资助金额:
$ 23.99万 - 项目类别:
COMPARATIVE STUDIES OF PRIMATE BRAIN ORGANIZATION USING MRI
使用 MRI 对灵长类动物大脑组织进行比较研究
- 批准号:
8172364 - 财政年份:2010
- 资助金额:
$ 23.99万 - 项目类别:
Vasopressin Effects on Emotional Social Communication
加压素对情感社交沟通的影响
- 批准号:
8686952 - 财政年份:2010
- 资助金额:
$ 23.99万 - 项目类别:
Neurobiological and Genetic Correlates of Cooperative Behavior
合作行为的神经生物学和遗传相关性
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- 资助金额:
$ 23.99万 - 项目类别:
Neurobiological and Genetic Correlates of Cooperative Behavior
合作行为的神经生物学和遗传相关性
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8287202 - 财政年份:2009
- 资助金额:
$ 23.99万 - 项目类别:
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