Neurobiological and Genetic Correlates of Cooperative Behavior

合作行为的神经生物学和遗传相关性

• 批准号: 8616876
• 负责人: JAMES K RILLING
• 金额: $ 9.75万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8616876
• 关键词: AVPR1A gene; Algorithms; Anatomy; Autistic Disorder; Behavior; Biological; Brain; Brain region; Brain scan; Computational algorithm; Computers; Cooperative Behavior; DNA; DNA analysis; DRD4 gene; Data; Decision Making; Diffusion Magnetic Resonance Imaging; Dopamine Receptor; Double-Blind Method; Economics; Exons; Frequencies; Functional Magnetic Resonance Imaging; Genes; Genetic; Genetic Polymorphism; Genetic Variation; Goals; Human; Image; Individual; Intranasal Administration; Investigation; MRI Scans; Measures; Mental Depression; Mental disorders; Minisatellite Repeats; Neurobiology; Neuropeptides; Neurotransmitter Receptor; Outcome; Oxytocin; Oxytocin Receptor; Patient Self-Report; Personality Disorders; Placebo Control; Placebos; Play; Population; Prefrontal Cortex; Prisoner' s Dilemma; Randomized; Route; Saliva; Sampling; Scanning; Self-Administered; Sexual Partners; Social Behavior; System; Testing; Trust; Variant; Vasopressin Receptor; Vasopressins; base; emotional factor; gray matter; interest; morphometry; neural model; placebo controlled study; programs; psychopathic personality; research study; response; serotonin transporter; social; social attachment; social cooperation; white matter

DESCRIPTION (provided by applicant): The overall objective of this project is to explore the biological bases of individual variation in cooperative social behavior among normal subjects, with the goal of developing hypotheses to explain more extreme variation that manifests as mental illness. Cooperative behavior will be measured in an interactive social task known as the Prisoner's Dilemma (PD) Game. There are four specific aims. Aim 1 is to examine the relationship between individual variation in cooperative behavior and individual variation in brain function during the PD game. This will be accomplished by imaging subjects' brains with fMRI as they play an iterated Prisoner's Dilemma Game with each of two assumed human partners. These data will allow us to evaluate an existing model of the neural systems that facilitate and inhibit cooperation. Aim 2 is to examine the relationship between individual variation in cooperative behavior and individual variation in prefrontal cortex anatomy. This aim will involve acquiring a structural MRI scan from each subject to measure morphometric variation, as well as a diffusion tensor imaging (DTI) brain scan to measure white matter integrity. Aim 3 is to investigate the impact of intranasal oxytocin and vasopressin, neuropeptides associated with social bonding, on cooperative behavior and associated brain activity. In this placebo-controlled, double-blind experiment, subjects will be randomized to one of three conditions: intranasal oxytocin administration, intranasal vasopressin administration, or intranasal placebo administration. Functional brain activity and behavior will be compared across treatment groups. Aim 4 is to examine the relationship between individual variation in cooperative behavior and individual genetic variation. Saliva samples will be collected from each subject for analysis of genes hypothesized to have an influence on cooperative social behavior. Ultimately, these data will identify factors that contribute to trust and its reciprocation which are essential components of cooperative social behavior. Trust and its reciprocation are essential components of healthy interpersonal relationships, as evidenced by several psychiatric disorders in which they are lacking, including autism, depression, psychopathic personality disorder and several axis II personality disorders. By identifying factors that influence cooperative behavior in a normal population, this project will generate hypotheses as to the causes of more severe variation associated with mental illness.

描述（由申请人提供）：该项目的总体目标是探索正常受试者合作社会行为个体差异的生物学基础，目标是提出假设来解释表现为精神疾病的更极端的差异。合作行为将通过称为囚徒困境（PD）游戏的交互式社交任务来衡量。有四个具体目标。目标 1 是检查 PD 游戏期间合作行为的个体差异与大脑功能的个体差异之间的关系。这将通过使用功能磁共振成像对受试者的大脑进行成像来实现，因为受试者与两个假设的人类伙伴中的每一个都玩重复的囚徒困境游戏。这些数据将使我们能够评估促进和抑制合作的现有神经系统模型。目标 2 是检查合作行为的个体差异与前额叶皮层解剖结构的个体差异之间的关系。这一目标将包括获取每个受试者的结构 MRI 扫描以测量形态变化，以及扩散张量成像 (DTI) 脑部扫描以测量白质完整性。目标 3 是研究鼻内催产素和加压素（与社会联系相关的神经肽）对合作行为和相关大脑活动的影响。在这个安慰剂对照、双盲实验中，受试者将被随机分配到三种条件之一：鼻内施用催产素、鼻内加压素施用或鼻内安慰剂施用。将比较不同治疗组的功能性大脑活动和行为。目标 4 是检验合作行为的个体变异与个体遗传变异之间的关系。将从每个受试者身上收集唾液样本，用于分析假设对合作社会行为有影响的基因。最终，这些数据将确定有助于信任及其回报的因素，这是合作社会行为的重要组成部分。信任及其回报是健康人际关系的重要组成部分，一些缺乏信任的精神疾病就证明了这一点，包括自闭症、抑郁症、精神病性人格障碍和几种第二轴人格障碍。通过识别影响正常人群合作行为的因素，该项目将产生与精神疾病相关的更严重变异的原因的假设。

项目成果

Oxytocin and vasopressin modulation of prisoner's dilemma strategies.

• DOI: 10.1177/0269881120913145
• 发表时间: 2020-08
• 期刊: Journal of psychopharmacology (Oxford, England)
• 作者: Neto ML;Antunes M;Lopes M;Ferreira D;Rilling J;Prata D
• 通讯作者: Prata D

A common oxytocin receptor gene (OXTR) polymorphism modulates intranasal oxytocin effects on the neural response to social cooperation in humans.

• DOI: 10.1111/gbb.12234
• 发表时间: 2015-09
• 期刊: Genes, brain, and behavior
• 作者: Feng C;Lori A;Waldman ID;Binder EB;Haroon E;Rilling JK
• 通讯作者: Rilling JK

Neuroticism modulates the effects of intranasal vasopressin treatment on the neural response to positive and negative social interactions.

• DOI: 10.1016/j.neuropsychologia.2015.05.004
• 发表时间: 2015-07
• 期刊: NEUROPSYCHOLOGIA
• 影响因子: 2.6
• 作者: Feng, Chunliang;DeMarco, Ashley C.;Haroon, Ebrahim;Rilling, James K.
• 通讯作者: Rilling, James K.

Effects of intranasal oxytocin and vasopressin on cooperative behavior and associated brain activity in men.

• DOI: 10.1016/j.psyneuen.2011.07.013
• 发表时间: 2012-04
• 期刊: PSYCHONEUROENDOCRINOLOGY
• 影响因子: 3.7
• 作者: Rilling, James K.;DeMarco, Ashley C.;Hackett, Patrick D.;Thompson, Richmond;Ditzen, Beate;Patel, Rajan;Pagnoni, Giuseppe
• 通讯作者: Pagnoni, Giuseppe

Intranasal oxytocin modulates neural functional connectivity during human social interaction.

• DOI: 10.1002/ajp.22740
• 发表时间: 2018-10
• 期刊: American journal of primatology
• 影响因子: 2.4
• 作者: Rilling JK;Chen X;Chen X;Haroon E
• 通讯作者: Haroon E