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Neurobiological bases of paternal nurturance

父亲养育的神经生物学基础

基本信息

批准号：
8837662
负责人：
JAMES K RILLING
金额：
$ 18.21万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-15 至 2017-03-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): In modern, western societies like ours, being raised without a father is associated with a host of negative developmental outcomes for children, including substance abuse, aggression and conduct disorder, dropping out of school and risky sexual behavior in adolescence. When fathers are present, however, they are not always helpful, and a small minority are even abusive. On the other hand, children raised by sensitive, nurturing fathers have better cognitive, behavioral, social and psychological outcomes. The proposed project will investigate the neurobiology underlying sensitive fathering and determine whether a pharmacological intervention can enhance it. The first aim is to investigate the relationship between fathers' neural responses to infant picture and cry stimuli and actual behavior of fathers in everyday life as assessed by the Electronic Activated Recorder (EAR), a portable digital audio recorder that periodically records brief snippets of ambient sounds and unobtrusively samples acoustic observations of participants' momentary social environments and interactions within the natural flow of their lives. This aim will use previously collected EAR data from 60 fathers of 1-3 year old children to code several measures of paternal behavior. Measures of paternal behavior will then be correlated with previously collected neuroimaging data from the same fathers. Aim 2 will determine if intranasal OT or AVP alter paternal neural responses to own child picture and cry stimuli. Thirty fathers with 1- 3 year old children will be imaged with fMRI as they view pictures of their own and unknown children and as they listen to unknown infant cry stimuli. Fathers will be scanned on two separate occasions; once under the influence of OT (n=15) or AVP (n=15), and once under the influence of a placebo. Order of administration will be counterbalanced across subjects. Ultimately, it is hoped that interventions like these will improve children's mental and physical health by virtue of their effects on the bran physiology and behavior of at-risk fathers (e.g., abusive fathers, fathers with post-partum depression).

描述（由申请人提供）：在像我们这样的现代西方社会，在没有父亲的情况下长大会给儿童带来一系列负面的发育后果，包括药物滥用、攻击性和行为障碍、辍学和青春期的危险性行为。然而，当父亲在场时，他们并不总是提供帮助，少数人甚至会辱骂。另一方面，由敏感、有教养的父亲抚养长大的孩子有更好的认知、行为、社会和心理结果。拟议的项目将研究敏感父亲行为背后的神经生物学，并确定药物干预是否可以增强它。第一个目的是调查父亲对婴儿图片和哭泣刺激的神经反应与父亲在日常生活中的实际行为之间的关系，并通过电子激活录音机（EAR）进行评估。EAR是一种便携式数字录音机，可以定期记录环境声音的简短片段，并对参与者的瞬时社交环境和生活自然流程中的互动进行不引人注目的声学观察采样。此目标将使用之前收集的 EAR 来自 60 位 1-3 岁儿童父亲的数据，用于编码父亲行为的几种衡量标准。然后，对父亲行为的测量将与之前从同一父亲收集的神经影像数据相关联。目标 2 将确定鼻内 OT 或 AVP 是否会改变父亲对自己孩子的照片和哭泣刺激的神经反应。 30 名有 1-3 岁孩子的父亲将在观看自己和未知孩子的照片以及聆听未知婴儿哭声刺激时接受功能磁共振成像成像。父亲将在两个不同的场合接受扫描；一次在 OT (n=15) 或 AVP (n=15) 的影响下，一次在安慰剂的影响下。管理顺序将在各个科目之间平衡。最终，希望此类干预措施能够通过对高危父亲（例如虐待父亲、产后抑郁症父亲）的麸皮生理和行为的影响来改善儿童的心理和身体健康。