Effects of Sleep enhancement on affectve functioning

睡眠增强对情感功能的影响

• 批准号: 8107511
• 负责人: Ronald E. Dahl
• 金额: $ 15.72万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8107511
• 关键词: Accidents; Address; Adolescence; Affect; Affective; Age; Alcohol or Other Drugs use; Alcohols; Anxiety; Anxiety Disorders; Behavioral; Bipolar Disorder; Child; Chronic Insomnia; Circadian Rhythms; Clinical; Clinical assessments; Cognitive; Development; Dysthymic Disorder; Early treatment; Emotional; Felis catus; Generalized Anxiety Disorder; Goals; Health; Home environment; Intervention; Laboratories; Lead; Long-Term Effects; Measures; Mediating; Mental Depression; Metabolic syndrome; Mood Disorders; Moods; Nicotine; Obesity; Outcome; Outcome Measure; Prevention strategy; Puberty; Public Health; Randomized; Regulation; Risk; Risk Factors; Role; Schedule; Sleep; Sleep Disorders; Sleep disturbances; Social Functioning; Social Policies; Stress; Substance Use Disorder; Symptoms; System; Testing; Time; Treatment Protocols; Youth; actigraphy; behavior observation; clinically relevant; coping; distress tolerance; early adolescence; emotion regulation; follow-up; improved; primary outcome; protective effect; vigilance

The primary goals of this project are to examine the short and long-term effects of improving sleep as an important component of treating anxiety disorders in youth. These goals build upon four lines of evidence regarding sleep and emotion regulation in adolescence: 1) Developmental changes in sleep, circadian, and affective systems at puberty create increased vulnerabilities for both sleep and emotional problems (and their interactions) in ways that lead to high rates of sleep difficulties in adolescence. 2) Youth with Generalized Anxiety Disorder are particularly prone to sleep problems because of increased vigilance and inclinations to worry and ruminate at bedtime; 3) Sleep loss can interfere with affect regulation and distress tolerance, and thus, sleep difficulties create added burdens in the domains of affective and social functioning. 4) Insomnia and chronic sleep disturbance are significant risk factors for the development of depression and other adverse health outcomes. Taken together, these four lines of evidence raise compelling questions regarding the opportunities for early intervention to improve and enhance sleep in youth with anxiety. Project 2 addresses these questions by: (a) assessing sleep changes during CBT for anxiety to examine whether sleep improvements may partially mediate some positive effects of CBT; (b) offering a six-week sleep intervention to those children who continue to show sleep difficulties after CBT (c) testing this sleep intervention by randomizing 2/3 to receive the multi-component sleep intervention and 1/3 to receive a comparison supportive treatment; and (d) assessing whether improving sleep will further enhance affective, clinical, and social functioning. This project addresses a set of issues of considerable clinical relevance in treating anxiety disorders. It also examines early adolescence as a key time in development for sleep intervention in ways that could inform a prevention strategy for depression. More generally, this project addresses issues of great concern to public health and social policy regarding the consequences of insufficient sleep in youth¿not only its effects on cognitive, emotional, behavioral, and academic function, but also a broader range of health problems where sleep has been implicated, including the development of affective disorders, alcohol, nicotine, and other substance use, accidents, and obesity and metabolic syndrome.

这个项目的主要目标是检查改善睡眠作为一种治疗方法的短期和长期效果。 治疗青少年焦虑症的重要组成部分。这些目标建立在四条证据基础上 关于青春期的睡眠和情绪调节：1）睡眠、昼夜节律和 青春期的情感系统会增加睡眠和情绪问题的脆弱性（以及 他们的相互作用）导致青春期睡眠困难的高比率。2)青春有 广泛性焦虑症特别容易出现睡眠问题，因为警觉性增加， 倾向于担心和沉思在睡前; 3）睡眠不足会干扰情绪调节和痛苦 耐受性，因此，睡眠困难在情感和社会领域造成额外的负担 功能4)失眠和慢性睡眠障碍是发生睡眠呼吸暂停的重要危险因素。 抑郁症和其他不良健康后果。综合起来，这四条证据提出了 关于早期干预改善和增强睡眠的机会的令人信服的问题， 青春焦虑项目2通过以下方式解决这些问题：（a）评估CBT期间的睡眠变化， 检查睡眠改善是否可以部分介导CBT的一些积极影响的焦虑;（B） 为那些在CBT后继续表现出睡眠困难的儿童提供为期六周的睡眠干预（c） 通过随机化2/3接受多组分睡眠干预和1/3接受多组分睡眠干预来测试该睡眠干预 接受比较支持治疗;以及（d）评估改善睡眠是否会进一步 增强情感、临床和社会功能。该项目解决了一系列问题， 治疗焦虑症的临床意义。它还研究了青春期早期作为一个关键时期， 睡眠干预的方法可以为抑郁症的预防策略提供信息。更 总的来说，该项目涉及公共卫生和社会政策极为关注的问题， 青年睡眠不足的后果不仅影响认知，情绪，行为， 学术功能，但也涉及更广泛的健康问题，其中睡眠，包括 情感障碍、酒精、尼古丁和其他物质使用、事故和肥胖的发展 和代谢综合征。