Emotion Regulation in Adolescence: A Social Affective Neuroscience Approach

青春期的情绪调节：社会情感神经科学方法

• 批准号: 7893796
• 负责人: Ronald E. Dahl
• 金额: $ 28.65万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-26 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7893796
• 关键词: Address; Adolescence; Adolescent; Adolescent Development; Adult; Affect; Affective; Alcohol abuse; Area; Behavior; Behavioral; Behavioral Medicine; Biological; Biological Process; Cellular Phone; Child; Childhood; Chronic; Clinical; Collection; Data; Development; Dimensions; Discipline; Disease; Early treatment; Elements; Emotional; Emotions; Family; Functional Magnetic Resonance Imaging; Goals; Health; Home environment; Hour; Impairment; Investigation; Laboratories; Lead; Measurement; Measures; Mental Depression; Mental Health; Methodology; Methods; Mission; Moods; Morbidity - disease rate; National Institute of Child Health and Human Development; National Institute of Drug Abuse; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Neuraxis; Neurobiology; Neurosciences; Parent-Child Relations; Parents; Patients; Peripheral Nervous System; Pharmaceutical Preparations; Play; Prevention; Preventive Intervention; Process; Program Development; Property; Protocols documentation; Psyche structure; Psychology; Psychometrics; Psychopathology; Puberty; Public Health; Recurrence; Regulation; Relative (related person); Research; Research Personnel; Risk; Risk-Taking; Role; Sampling; Scientist; Social Environment; Social Functioning; Social Interaction; Stimulus; System; Testing; Time; Treatment Protocols; Work; affective neuroscience; base; behavior observation; behavioral health; brain behavior; clinically significant; cost; emotion regulation; emotional stimulus; experience; high risk; information processing; innovation; intervention program; millisecond; mortality; neurobehavioral; peer; social; social neuroscience; tool; tool development

DESCRIPTION (provided by applicant): Mental and behavioral health during adolescence is an area of critical public health concern because morbidity and mortality rates increase 200-300% from childhood to late adolescence. A major dimension of these serious health problems is related to difficulties with the control of emotions. In order to understand how challenges to emotion regulation during adolescence contribute to specific health problems, researchers need better tools for measuring emotional reactivity and regulation during this developmental period. This project applies a developmentally informed social affective neuroscience perspective to the development of a new "toolbox" for studying emotional reactivity and regulation in adolescence. This requires an integration of the fields of developmental psychopathology, social neuroscience, and affective neuroscience. Combining key elements of these disciplines will facilitate the development of tools grounded in neuroscience that also have broader developmental, clinical, and social relevance. Because of the importance of the social sphere in adolescence, we focus on socially relevant paradigms that will facilitate an understanding of how social influences (e.g. parents, peers, media) contribute to adolescents' emotionality, and how neurobiological substrates underlie social and emotional processes. Specifically, we will develop and refine 3 sets of tools: (a) laboratory pupillary and functional magnetic resonance imaging (fMRI) social-emotional information processing tasks; (b) behavioral observation of parent-child affective interactions with concurrent pupillary data; and (c) a cell-phone based Ecological Momentary Assessment (EMA) protocol measuring adolescents' emotional reactivity and regulation in natural social contexts. Our aims are to (1) develop and establish initial psychometric properties for these measures, (2) integrate these measurement approaches across levels of context and time, and (3) examine the validity of these approaches in discriminating clinical groups and detecting developmental/pubertal differences in emotional reactivity and regulation. As first steps, we will focus specifically on the utility of these methods in research on adolescent depression--a common and debilitating adolescent health problem associated with chronic and recurrent impairment into adulthood. Innovative aspects of this work include the development of new methodologies for sampling "real-world" phenomena, integration of neuroscience with the social environment by developing laboratory paradigms that tap social processes, and improvements in the assessment of co-occurring social and biological processes through the development of mood inductions and peer and parent-child interaction tasks that can be used to collect concurrent neurobiological, behavioral and observational data. Ultimately, these tools could be useful for investigators examining a wide range of adolescent health problems across disciplines, including researchers in the areas of high risk research, treatment and prevention, longitudinal developmental research, psychology, neuroscience, and behavioral medicine. Developing new biological and ecological tools for measuring emotional reactivity and regulation is relevant to the missions of NICHD, NIMH, NIDA, and NIAAA in that emotion regulation has been identified as a critical yet poorly understood domain in normative child and adolescent development and in the development of problems in mental health, drug and alcohol abuse, and risk-taking and reckless behavior that leads to a broad range of health consequences. Developing tools that can facilitate a better understanding of the mechanisms through which emotional reactivity and regulation contribute to adolescent health is critical because it could lead to improvements or adaptations of existing prevention and intervention programs, the development of new prevention and intervention programs based on new scientific discoveries, and better matching of patients to specific treatment protocols based on emotional profiles. Tools that can identify initial disruptions in emotion regulation and facilitate early intervention during this period of relative plasticity could lead to long-term reductions in health-related cost and suffering in adulthood.

描述（由申请人提供）：青春期的心理和行为健康是一个关注公共卫生关注的领域，因为从童年到青春期，发病率和死亡率增加了200-300％。这些严重的健康问题的一个主要维度与控制情绪的困难有关。为了了解青少年期间对情绪调节的挑战如何助长特定的健康问题，研究人员需要更好的工具来衡量在此发展期间的情绪反应性和调节。该项目将知情的社会情感神经科学观点应用于开发新的“工具箱”，用于研究青春期的情绪反应性和调节。这需要整合发展心理病理学，社会神经科学和情感神经科学领域。结合这些学科的关键要素将有助于开发基于神经科学的工具，这些工具也具有更广泛的发展，临床和社会相关性。由于社会领域在青春期的重要性，我们专注于与社会相关的范式，这些范式将有助于了解社会影响（例如父母，同伴，媒体）如何促进青少年的情感以及神经生物学基质的影响。具体来说，我们将开发和完善3组工具：（a）实验室瞳孔和功能磁共振成像（fMRI）社会情感信息处理任务； （b）与并发瞳孔数据的亲子情感互动的行为观察； （c）基于手机的生态瞬时评估（EMA）协议，测量青少年在自然社会环境中的情绪反应性和调节。我们的目的是（1）为这些措施开发和建立初始的心理测量特性，（2）在上下文和时间层面整合这些测量方法，以及（3）研究这些方法在区分临床组中的有效性并检测到情绪反应性和调节方面的发育/青春期差异。作为第一步，我们将专门关注这些方法在青少年抑郁症研究中的实用性，这是一个常见且令人衰弱的青少年健康问题，与慢性和经常性损害有关，直到成年期。这项工作的创新方面包括开发用于取样“现实世界”现象的新方法，通过开发利用社会过程的实验室范式来融入神经科学与社会环境，以及在社交和生物学过程中的评估中的改善，通过对情绪诱导的发展以及与养育互动的发展进行互为互动，以使社会和生物学过程相互依赖于互动，以促进互动。最终，这些工具对于研究跨学科的各种青春期健康问题的研究人员可能很有用，包括高风险研究，治疗和预防领域的研究人员，纵向发展研究，心理学，神经科学和行为医学。开发用于衡量情绪反应性和调节的新的生物学和生态工具与NICHD，NIMH，NIDA和NIAAA的任务有关，因为情绪调节已被确定为在规范性的儿童和青少年发展中以及在精神健康，药物滥用，毒品滥用和冒险行为方面的关键性尚不细致的领域，并且在范围内造成了广泛的范围。开发可以更好地理解情绪反应性和调节对青少年健康的机制的工具至关重要，因为它可能导致现有的预防和干预计划的改进或适应，基于新的科学发现的新预防和干预计划的发展，以及将患者更好地匹配基于情绪概况的特定治疗方案。在此相对可塑性期间，可以确定情绪调节并促进早期干预的工具可能会导致长期降低与健康相关的成本和成年后的痛苦。

项目成果

"Loser" or "Popular"?: Neural response to social status words in adolescents with major depressive disorder.

• DOI: 10.1016/j.dcn.2017.09.005
• 发表时间: 2017-12
• 期刊: Developmental cognitive neuroscience
• 影响因子: 4.7
• 作者: Silk JS;Lee KH;Kerestes R;Griffith JM;Dahl RE;Ladouceur CD
• 通讯作者: Ladouceur CD