CONTINUATION OF THE NATIONAL MESOTHELIOMA VIRTUAL BANK

国家间皮瘤虚拟银行的延续

• 批准号: 8246704
• 负责人: MICHAEL JOHN BECICH
• 金额: $ 102.2万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8246704
• 关键词: CONTINUATION; NATIONAL; MESOTHELIOMA; VIRTUAL; BANK

DESCRIPTION (provided by applicant): The purpose of the National Mesothelioma Virtual Bank (NMVB) for Translational Research is to maximize the effectiveness of data and biospecimen collection and sharing for mesothelioma research nationally. The NMVB will continue to serve as a resource that will allow researchers real time access to clinical data associated with blood, DNA and tissue specimens from the registry, thus expanding scientific discovery and effective treatments to benefit the Mesothelioma clinical and translational research and patient communities. Our specific aims are: 1) To expand the NMVB to Mt. Sinai School of Medicine. We will continue to collect patients' clinical data and enroll them in the biospecimen bank at the original NMVB partners: New York University (NYU), the University of Pennsylvania (Penn), the University of Pittsburgh (Pitt). At all sites, we will collect biological samples including (but not limited to) biopsy material (fixed or frozen), blood, serum and white blood cells (for DNA). This will include continuing to accrue prospective cases, retrospective cases and case controls; 2) To expand the NMVB collection sites to the University of Hawaii Cancer Center and the University of California San Francisco through the "SPIRIT of Collaboration" and to facilitate translational research from funded Investigators by the Meso Foundation and proposed Mesothelioma SPORE; and, 3) We will document and continually evaluate the usefulness of the NMVB to the scientific community and measure its impact in studies that address the etiology, mechanisms, diagnosis and treatment of malignant mesothelioma. The advantages of this approach which we call "The SPIRIT of Collaboration" is that it will begin to couple funding sources from the CDC NIOSH to the NCI (through the Meso SPORE) and NCRR (through the CTSA program). This effort will serve as a model for multi-agency funding of synergistic efforts. The NIH Roadmap stresses the importance of collaborative networks of researchers and the sharing of biospecimen resources and the National Mesothelioma Virtual Bank program of NIOSH/CDC clearly alms to facilitate that vision. PUBLIC HEALTH RELEVANCE: Mesothelioma peak incidence is expected in 2020. In the U.S. approximately 72,000 new cases are expected by 2026. There is no cure for mesothelioma and effective treatments are limited. Research efforts like NMVB are key to the discovery of tools to combat this disease. NMVB will greatly facilitate research by providing quality blospeclmens and data to help prevent and eventually cure this uniformly deadly disease.

描述（由申请人提供）：国家间皮瘤虚拟银行（NMVB）转化研究的目的是最大限度地提高间皮瘤研究的数据和生物标本收集和共享的有效性。NMVB将继续作为一种资源，使研究人员能够真实的时间访问与注册表中的血液，DNA和组织标本相关的临床数据，从而扩大科学发现和有效的治疗方法，使间皮瘤临床和转化研究以及患者社区受益。我们的具体目标是：1）将NMVB扩大到Mt。西奈医学院。我们将继续收集患者的临床数据，并将其纳入NMVB原始合作伙伴的生物标本库：纽约大学（NYU）、宾夕法尼亚大学（Penn）、匹兹堡大学（Pitt）。在所有研究中心，我们将采集生物样本，包括（但不限于）活检材料（固定或冷冻）、血液、血清和白色血细胞（用于DNA）。这将包括继续累积前瞻性病例、回顾性病例和病例对照; 2）通过“协作精神”将NMVB收集地点扩展到夏威夷大学癌症中心和加州大学旧金山弗朗西斯科，并促进Meso基金会资助的研究者和拟议的间皮瘤SPORE的转化研究;和，3）我们将记录和不断评估NMVB对科学界的有用性，并衡量其在研究恶性间皮瘤的病因，机制，诊断和治疗方面的影响。我们称之为“协作精神”的这种方法的优点是，它将开始将CDC NIOSH的资金来源与NCI（通过Meso SPORE）和NCRR（通过CTSA计划）结合起来。这一努力将成为多机构为协同努力供资的模式。NIH路线图强调了研究人员合作网络和生物标本资源共享的重要性，NIOSH/CDC的国家间皮瘤虚拟银行计划明确帮助促进这一愿景。 公共卫生相关性：间皮瘤发病高峰预计在2020年。在美国，预计到2026年将有大约72，000例新病例。有没有治愈间皮瘤和有效的治疗是有限的。像NMVB这样的研究工作是发现对抗这种疾病的工具的关键。NMVB将通过提供高质量的生物样本和数据来帮助预防并最终治愈这种致命的疾病，从而极大地促进研究。