CONTINUATION OF THE NATIONAL MESOTHELIOMA VIRTUAL BANK

描述（由申请人提供）：转化研究国家间皮瘤虚拟库（NMVB）的目的是最大限度地提高数据和生物标本收集和共享在全国间皮瘤研究中的有效性。NMVB将继续作为一个资源，使研究人员能够实时访问与血液、DNA和组织标本相关的临床数据，从而扩大科学发现和有效治疗，使间皮瘤临床和转化研究以及患者群体受益。我们的具体目标是：1)将NMVB扩展到西奈山医学院。我们将继续收集患者的临床数据，并将其纳入NMVB的原始合作伙伴：纽约大学（NYU）、宾夕法尼亚大学（Penn）、匹兹堡大学（Pitt）的生物标本库。在所有地点，我们将收集生物样本，包括（但不限于）活检材料（固定或冷冻）、血液、血清和白细胞（用于DNA）。这将包括继续积累前瞻性病例、回顾性病例和病例对照；2)通过“合作精神”将NMVB收集点扩展到夏威夷大学癌症中心和加州大学旧金山分校，并促进由Meso基金会资助的研究人员和拟议的间皮瘤孢子的转化研究；3)我们将记录并持续评估NMVB对科学界的有用性，并衡量其在恶性间皮瘤的病因、机制、诊断和治疗研究中的影响。这种我们称之为“合作精神”的方法的优势在于，它将开始将来自CDC NIOSH的资金来源与NCI（通过Meso SPORE）和NCRR（通过CTSA计划）结合起来。这一努力将成为多机构为协同努力提供资金的典范。NIH路线图强调了研究人员合作网络和生物标本资源共享的重要性，NIOSH/CDC的国家间皮瘤虚拟银行项目显然有助于促进这一愿景。

DESCRIPTION (provided by applicant): The purpose of the National Mesothelioma Virtual Bank (NMVB) for Translational Research is to maximize the effectiveness of data and biospecimen collection and sharing for mesothelioma research nationally. The NMVB will continue to serve as a resource that will allow researchers real time access to clinical data associated with blood, DNA and tissue specimens from the registry, thus expanding scientific discovery and effective treatments to benefit the Mesothelioma clinical and translational research and patient communities. Our specific aims are: 1) To expand the NMVB to Mt. Sinai School of Medicine. We will continue to collect patients' clinical data and enroll them in the biospecimen bank at the original NMVB partners: New York University (NYU), the University of Pennsylvania (Penn), the University of Pittsburgh (Pitt). At all sites, we will collect biological samples including (but not limited to) biopsy material (fixed or frozen), blood, serum and white blood cells (for DNA). This will include continuing to accrue prospective cases, retrospective cases and case controls; 2) To expand the NMVB collection sites to the University of Hawaii Cancer Center and the University of California San Francisco through the "SPIRIT of Collaboration" and to facilitate translational research from funded Investigators by the Meso Foundation and proposed Mesothelioma SPORE; and, 3) We will document and continually evaluate the usefulness of the NMVB to the scientific community and measure its impact in studies that address the etiology, mechanisms, diagnosis and treatment of malignant mesothelioma. The advantages of this approach which we call "The SPIRIT of Collaboration" is that it will begin to couple funding sources from the CDC NIOSH to the NCI (through the Meso SPORE) and NCRR (through the CTSA program). This effort will serve as a model for multi-agency funding of synergistic efforts. The NIH Roadmap stresses the importance of collaborative networks of researchers and the sharing of biospecimen resources and the National Mesothelioma Virtual Bank program of NIOSH/CDC clearly alms to facilitate that vision. PUBLIC HEALTH RELEVANCE: Mesothelioma peak incidence is expected in 2020. In the U.S. approximately 72,000 new cases are expected by 2026. There is no cure for mesothelioma and effective treatments are limited. Research efforts like NMVB are key to the discovery of tools to combat this disease. NMVB will greatly facilitate research by providing quality blospeclmens and data to help prevent and eventually cure this uniformly deadly disease.